公开(公告)号：DE60206164T2

公开(公告)日：2006-06-22

申请号：DE60206164

申请日：2002-05-14

Applicant: ABBOTT LAB

Inventor： LEE CHIH-HUNG ,  PERNER J ,  LARSON P ,  KOENIG R ,  GOMTSYAN R ,  ZHENG GUO ZHU ,  DIDOMENICO STANLEY ,  STEWART O ,  BAYBURT K

IPC: C07C233/74 ,  A61K31/166 ,  A61K31/18 ,  A61K31/194 ,  A61K31/275 ,  A61K31/277 ,  A61K31/351 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/505 ,  A61P13/00 ,  A61P13/02 ,  A61P13/10 ,  A61P21/00 ,  A61P25/04 ,  A61P43/00 ,  C07C233/65 ,  C07C233/66 ,  C07C233/76 ,  C07C233/79 ,  C07C251/48 ,  C07C251/52 ,  C07C255/60 ,  C07C311/51 ,  C07C321/24 ,  C07D207/06 ,  C07D213/40 ,  C07D213/68 ,  C07D213/71 ,  C07D239/34 ,  C07D309/12 ,  C07D309/32 ,  C07D317/72 ,  C07D333/20 ,  C07D333/34 ,  C07D333/40 ,  C07D333/42 ,  C07D333/68 ,  C07D333/72

公开(公告)号：DE69926903D1

公开(公告)日：2005-09-29

申请号：DE69926903

申请日：1999-10-27

Applicant: ABBOTT LAB

Inventor： BLACK A ,  BASHA ANWER ,  KOLASA TEODOZYJ ,  KORT E ,  LIU HUAQING ,  MCCARTY M ,  PATEL V ,  ROHDE J ,  COGHLAN J ,  STEWART O

IPC: A61K31/50 ,  A61K31/501 ,  A61P19/02 ,  A61P25/04 ,  A61P29/00 ,  A61P35/00 ,  C07D237/14 ,  C07D237/16 ,  C07D237/18 ,  C07D237/22 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/06

Abstract: The present invention describes pyridazinone compounds of formula (I) which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important "housekeeping" enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectively of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).

公开(公告)号：DE69926903T2

公开(公告)日：2006-07-13

申请号：DE69926903

申请日：1999-10-27

Applicant: ABBOTT LAB

Inventor： BLACK A ,  BASHA ANWER ,  KOLASA TEODOZYJ ,  KORT E ,  LIU HUAQING ,  MCCARTY M ,  PATEL V ,  ROHDE J ,  COGHLAN J ,  STEWART O

IPC: C07D237/14 ,  A61K31/50 ,  A61K31/501 ,  A61P19/02 ,  A61P25/04 ,  A61P29/00 ,  A61P35/00 ,  C07D237/16 ,  C07D237/18 ,  C07D237/22 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/06

Abstract: The present invention describes pyridazinone compounds of formula (I) which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important "housekeeping" enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectively of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).

公开(公告)号：DE60206164D1

公开(公告)日：2005-10-20

申请号：DE60206164

申请日：2002-05-14

Applicant: ABBOTT LAB

Inventor： LEE CHIH-HUNG ,  PERNER J ,  LARSON P ,  KOENIG R ,  GOMTSYAN R ,  ZHENG GUO ZHU ,  DIDOMENICO STANLEY ,  STEWART O ,  BAYBURT K

IPC: A61K31/194 ,  A61K31/275 ,  A61K31/277 ,  A61K31/351 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/505 ,  A61P13/00 ,  A61P13/02 ,  A61P13/10 ,  A61P21/00 ,  A61P25/04 ,  A61P43/00 ,  C07C233/65 ,  C07C233/66 ,  C07C233/74 ,  C07C233/76 ,  C07C233/79 ,  C07C251/48 ,  C07C251/52 ,  C07C255/60 ,  C07C311/51 ,  C07C321/24 ,  C07D207/06 ,  C07D213/40 ,  C07D213/68 ,  C07D213/71 ,  C07D239/34 ,  C07D309/12 ,  C07D309/32 ,  C07D317/72 ,  C07D333/20 ,  C07D333/34 ,  C07D333/40 ,  C07D333/42 ,  C07D333/68 ,  C07D333/72 ,  A61K31/166 ,  A61K31/18