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公开(公告)号：JP2011063594A
公开(公告)日：2011-03-31
申请号：JP2010235798
申请日：2010-10-20
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： ALTENBACH ROBERT J , BLACK LAWRENCE A , CHANG SOU-JEN , COWART MARLON D , FAGHIH RAMIN , GFESSER GREGORY A , KU YI-YIN , LIU HUAQING , LUKIN KIRILL A , NERSESIAN DIANA L , PU YU-MING , SHARMA PADAM N , BENNANI YOUSSEF L , CURTIS MICHAEL P
IPC: C07C255/58 , A61P3/00 , A61P25/00 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/092 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
CPC classification number: C07C255/58 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
Abstract: PROBLEM TO BE SOLVED: To provide pharmaceutical compositions useful in treating conditions or disorders which are prevented or ameliorated by histamine-3 receptor ligands, a method of using such compounds and compositions, and a preparation process therefor.
SOLUTION: There are provided a compound of formula (I), pharmaceutically acceptable salts, esters, amides or prodrugs thereof. Pharmaceutical compositions, usage and preparation process therefor are also provided. In the formula, each symbol is defined specifically.
COPYRIGHT: (C)2011,JPO&INPITAbstract translation: 待解决的问题：提供可用于治疗由组胺-3受体配体预防或改善的病症或病症的药物组合物，使用这些化合物和组合物的方法及其制备方法。 解决方案：提供式（I）的化合物，其药学上可接受的盐，酯，酰胺或前药。 还提供了药物组合物，用途和制备方法。 在公式中，每个符号都被具体定义。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：WO2008060767A2
公开(公告)日：2008-05-22
申请号：PCT/US2007080133
申请日：2007-10-02
Applicant: ABBOTT LAB , ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , COWART MARLON D , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D
Inventor： ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , COWART MARLON D , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D , HANCOCK ARTHUR A
IPC: C07D491/04 , C07D493/04 , C07H17/04
CPC classification number: C07H17/04 , C07D239/70 , C07D403/12 , C07D453/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/04 , C07D495/04 , C07D519/00
Abstract: Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.
Abstract translation: 本文描述了大环苯并稠合的嘧啶化合物，包含此类化合物的组合物，制备所述化合物的方法以及使用此类化合物和组合物治疗和预防疾病，病症和障碍进展的方法。
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公开(公告)号：WO2008060766A3
公开(公告)日：2009-02-19
申请号：PCT/US2007080132
申请日：2007-10-02
Applicant: ABBOTT LAB , COWART MARLON D , ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D
Inventor： COWART MARLON D , ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D , HANCOCK ARTHUR A
IPC: A61K31/417 , A61K31/496 , A61K31/506 , A61K45/06 , A61P29/00
CPC classification number: A61K31/506 , A61K31/417 , A61K31/496 , A61K45/06
Abstract: This invention discloses histamine H4 receptor ligands for use in a method of treating pain
Abstract translation: 本发明公开了用于治疗疼痛的方法中的组胺H 4受体配体
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公开(公告)号：WO0166534A3
公开(公告)日：2003-10-16
申请号：PCT/US0106885
申请日：2001-03-05
Applicant: ABBOTT LAB
Inventor： BENNANI YOUSSEF L , BLACK LAWRENCE A , DWIGHT WESLEY J , FAGHIH RAMIN , GENTLES ROBERT G , LIU HUAQING , PHELAN KATHLEEN M , VASUDEVAN ANIL , ZHANG HENRY Q
IPC: A61P37/08 , C07D205/04 , C07D205/08 , C07D207/08 , C07D207/16 , C07D213/56 , C07D233/54 , C07D239/10 , C07D243/08 , C07D271/06 , C07D277/30 , C07D295/205 , C07D307/68 , C07D333/24 , C07D403/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D487/08 , A61K31/495
CPC classification number: C07D207/08 , C07D205/04 , C07D205/08 , C07D207/16 , C07D213/56 , C07D233/64 , C07D239/10 , C07D243/08 , C07D271/06 , C07D277/30 , C07D295/205 , C07D307/68 , C07D333/24 , C07D403/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D487/08
Abstract: Compounds of formula (I), compounds of formula (II), compounds of formula (III), and compounds of formula (IV), or pharmaceutically acceptable salts thereof are useful as H3 receptor antagonists. Processes to make the compounds and methods of treatment using the compounds are also disclosed.
Abstract translation: 式（I）化合物，式（II）化合物，式（III）化合物和式（IV）化合物或其药学上可接受的盐可用作H3受体拮抗剂。 还公开了制备化合物的方法和使用该化合物的处理方法。
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5.发明申请
公开(公告)号：WO2007150010A3
公开(公告)日：2008-05-02
申请号：PCT/US2007071849
申请日：2007-06-22
Applicant: ABBOTT LAB , LIU HUAQING , BLACK LAWRENCE A , BENNANI YOUSSEF L , COWART MARLON D
Inventor： LIU HUAQING , BLACK LAWRENCE A , BENNANI YOUSSEF L , COWART MARLON D
IPC: C07D207/06 , A61K31/397 , A61K31/4025 , A61K31/4196 , A61K31/4365 , A61K31/4439 , A61K31/454 , A61K31/455 , A61K31/501 , A61K31/506 , A61K31/55 , A61P25/00 , C07D401/10 , C07D403/10 , C07D417/10 , C07D495/04
CPC classification number: C07D207/06 , C07D401/10 , C07D403/10 , C07D417/10 , C07D495/04
Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
Abstract translation: 式（I）化合物可用于治疗组胺3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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Patent Agency Ranking
公开(公告)号：WO2006132914A3
公开(公告)日：2007-03-29
申请号：PCT/US2006021257
申请日：2006-06-01
Applicant: ABBOTT LAB , LIU HUAQING , HANCOCK ARTHUR A , COWART MARLON D
Inventor： LIU HUAQING , HANCOCK ARTHUR A , COWART MARLON D
IPC: C07D207/06 , A61K31/40 , A61K31/4439 , A61K31/506 , A61P25/00 , C07D401/10 , C07D403/10 , C07D417/10
CPC classification number: C07D207/06 , C07D401/10 , C07D403/10 , C07D417/10
Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
Abstract translation: 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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7.发明申请
公开(公告)号：WO2005113536A3
公开(公告)日：2006-03-30
申请号：PCT/US2005014866
申请日：2005-04-29
Applicant: ABBOTT LAB , ALTENBACH ROBERT J , BLACK LAWRENCE A , CHANG SOU-JEN , COWART MARLON D , FAGHIH RAMIN , GFESSER GREGORY A , KU YI-YIN , LIU HUAQING , LUKIN KIRILL A , NERSESIAN DIANA L , PU YU-MING , CURTIS MICHAEL P
Inventor： ALTENBACH ROBERT J , BLACK LAWRENCE A , CHANG SOU-JEN , COWART MARLON D , FAGHIH RAMIN , GFESSER GREGORY A , KU YI-YIN , LIU HUAQING , LUKIN KIRILL A , NERSESIAN DIANA L , PU YU-MING , CURTIS MICHAEL P
IPC: C07D401/00 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/02 , C07D471/04 , C07D487/04 , C07D491/02 , C07D491/04 , C07D495/04 , C07D498/02 , C07D513/04 , A61K31/4709 , A61K31/4725
CPC classification number: C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
Abstract: Compounds of formula (I) wherein R
Abstract translation: 式（I）的化合物，其中R 1，
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公开(公告)号：CA2709081C
公开(公告)日：2016-03-22
申请号：CA2709081
申请日：2008-12-05
Applicant: ABBOTT LAB
Inventor： LIU HUAQING , BLACK LAWRENCE A , BENNANI YOUSSEF L , COWART MARLON D , TIAN ZHENPING , BRACKEMEYER PAUL J
IPC: C07D295/14 , A61K31/40 , A61K31/41 , A61K31/44 , A61P25/00 , C07D401/12 , C07D403/12 , C07D417/12
Abstract: Compounds of formula (I) wherein R1, R2, R3, R3a, R3b, R4, and R5 are defined in the description, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
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公开(公告)号：CA2505427C
公开(公告)日：2012-04-03
申请号：CA2505427
申请日：2003-11-05
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , BLACK LAWRENCE A , CHANG SOU-JEN , COWART MARLON D , FAGHIH RAMIN , GFESSER GREGORY A , KU YI-YIN , LIU HUAQING , LUKIN KIRILL A , NERSESIAN DIANA L , PU YU-MING , SHARMA PADAM N , BENNANI YOUSSEF L , CURTIS MICHAEL P
IPC: C07D471/04 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/445 , A61K31/4709 , A61K31/4725 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/541 , A61P3/00 , A61P25/00 , C07C255/58 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/092 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
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公开(公告)号：ECSP10010253A
公开(公告)日：2010-07-30
申请号：ECSP10010253
申请日：2010-06-14
Applicant: ABBOTT LAB
Inventor： COWART MARLON D , LIU HUAQING , BLACK LAWRENCE A , BENNANI YOUSSEF L , BRACKEMEYER PAUL J , TIAN ZHENPING
IPC: A61K31/40 , A61K31/44 , A61P25/00 , C07D295/14 , C07D401/12 , C07D403/12
Abstract: Compuestos con la fórmula (I) donde R1, R2, R3, R3a, R3b, R4, and R5 tienen los valores que se definen en la memoria descriptiva, que son útiles para tratar condiciones o trastornos que se pueden prevenir o mejorar mediante los ligandos del receptor de histamina-3. También se divulgan composiciones farmacéuticas que comprenden los ligandos del receptor de histamina-3, métodos para usar dichos compuestos y composiciones, y un proceso para preparar compuestos dentro del alcance de la fórmula (I).
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