公开(公告)号：CA2255909A1

公开(公告)日：1997-12-11

申请号：CA2255909

申请日：1997-06-03

Applicant: ABBOTT LAB

Inventor： SUBOTICH DANIEL T ,  MEES DAVID R ,  JOSEPH MARY K ,  POPE MARK R ,  PRY TERRY A ,  TARCHA PETER J ,  PUTMAN C BRENT

IPC: G01N33/543 ,  G01N33/547 ,  G01N33/545

Abstract: A method for increasing the binding activity of specific binding members bound to a solid phase material, e.g., a particle, that has been sterically stabilized. This increase in binding activity is brought about by degrading a steric stabilizer on the surface of the solid phase material. The method involves both immobilizing a specific binding member on the surface of a solid phase material and degrading a steric stabilizer on the surface of that solid phase material. In the preferred embodiment, the method involves the immobilization of a specific binding member on the surface of the sterically stabilized solid phase material, with subsequent degradation of the steric stabilizer.

公开(公告)号：AT223053T

公开(公告)日：2002-09-15

申请号：AT97926857

申请日：1997-06-03

Applicant: ABBOTT LAB

Inventor： POPE MARK R ,  TARCHA PETER J ,  MEES DAVID R ,  JOSEPH MARY K ,  PRY TERRY A ,  PUTMAN C BRENT ,  SUBOTICH DANIEL T

IPC: G01N33/543 ,  G01N33/547 ,  G01N33/545 ,  G01N33/546