公开(公告)号：DE60019121D1

公开(公告)日：2005-05-04

申请号：DE60019121

申请日：2000-06-23

Applicant: ABBOTT LAB

Inventor： CARROLL A ,  CHEN YIYUAN ,  HOLLADAY W ,  KORT E ,  KYM R ,  SULLIVAN P ,  TANG RUI ,  YI LIN ,  ZHANG Q

IPC: A61K31/4365 ,  A61K31/44 ,  A61K31/47 ,  A61K31/4743 ,  A61P1/14 ,  A61P9/08 ,  A61P9/12 ,  A61P11/06 ,  A61P13/00 ,  A61P13/02 ,  A61P15/00 ,  A61P15/02 ,  A61P15/10 ,  A61P25/00 ,  A61P25/06 ,  A61P25/08 ,  A61P43/00 ,  C07C45/00 ,  C07C45/29 ,  C07C45/41 ,  C07C45/63 ,  C07C45/71 ,  C07C205/44 ,  C07D215/36 ,  C07D221/04 ,  C07D495/04 ,  C07D495/14

公开(公告)号：DE69823227T2

公开(公告)日：2005-03-10

申请号：DE69823227

申请日：1998-12-16

Applicant: ABBOTT LAB

Inventor： CARROLL A ,  HOLLADAY W ,  SULLIVAN P ,  DRIZIN IRENE ,  ZHANG Q

IPC: A61K31/4365 ,  A61K31/47 ,  A61K31/4743 ,  A61P1/00 ,  A61P1/14 ,  A61P9/08 ,  A61P9/12 ,  A61P11/06 ,  A61P13/02 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  C07C45/29 ,  C07D215/36 ,  C07D221/04 ,  C07D495/04 ,  C07D495/14 ,  C07D211/84 ,  A61K31/44 ,  A61K31/38

Abstract: Compounds having the formula are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：DE69823227D1

公开(公告)日：2004-05-19

申请号：DE69823227

申请日：1998-12-16

Applicant: ABBOTT LAB

Inventor： CARROLL A ,  HOLLADAY W ,  SULLIVAN P ,  DRIZIN IRENE ,  ZHANG Q

IPC: A61K31/4365 ,  A61K31/47 ,  A61K31/4743 ,  A61P1/00 ,  A61P1/14 ,  A61P9/08 ,  A61P9/12 ,  A61P11/06 ,  A61P13/02 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  C07C45/29 ,  C07D215/36 ,  C07D221/04 ,  C07D495/04 ,  C07D495/14 ,  C07D211/84 ,  A61K31/44 ,  A61K31/38

Abstract: Compounds having the formula are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：DE69717148T2

公开(公告)日：2003-10-02

申请号：DE69717148

申请日：1997-12-10

Applicant: ABBOTT LAB

Inventor： HOLLADAY W ,  ARNERIC P ,  BAI HAO ,  DART J ,  LIN NAN-HORNG ,  LYNCH K ,  OR SUN ,  RYTHER B ,  SULLIVAN P ,  WASICAK T ,  EHRLICH P

IPC: A61P25/04 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/485 ,  A61P25/28 ,  A61P29/00 ,  C07D205/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  A61K31/44

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：DE69717148D1

公开(公告)日：2002-12-19

申请号：DE69717148

申请日：1997-12-10

Applicant: ABBOTT LAB

Inventor： HOLLADAY W ,  ARNERIC P ,  BAI HAO ,  DART J ,  LIN NAN-HORNG ,  LYNCH K ,  OR SUN ,  RYTHER B ,  SULLIVAN P ,  WASICAK T ,  EHRLICH P

IPC: A61P25/04 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/485 ,  A61P25/28 ,  A61P29/00 ,  C07D205/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  A61K31/44

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.