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    4{41 -o-sulfonyl erythromycin-9-o-oxime derivatives
    1.
    发明授权
    4{41 -o-sulfonyl erythromycin-9-o-oxime derivatives 失效
    4 {41-邻 - 亚甲基红霉素-9-O-氧化衍生物

    公开(公告)号：US3855203A

    公开(公告)日：1974-12-17

    申请号：US35698773

    申请日：1973-05-03

    Applicant: ABBOTT LAB

    Inventor： HALLAS R ,  TADANIER J ,  VON ESCH A

    IPC: A61K31/335 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07C129/18

    CPC classification number: C07H17/08

    Abstract: Covers 4''''-O-sulfonyl erythromycin-9-O-oxime derivatives falling within the following structural formula: WHERE R is selected from the group consisting of loweralkyl, loweralkenyl, aryl, substituted aryl, benzyl and substituted benzyl, R1 is hydrogen or methyl, R2 is hydrogen or loweralkanoyl, R3 is hydrogen or hydroxyl, and R4 is selected from the group consisting of loweralkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, benzyl and substituted benzyl. These 9-O-oxime derivative compounds are useful as antibiotics.

    Abstract translation: 涵盖落在以下结构式中的4“-O-磺酰基红霉素-9-O-肟衍生物：

    Method for combating herpes simplex virus
    2.
    发明授权
    Method for combating herpes simplex virus 失效
    用于组合简单病毒的方法

    公开(公告)号：US3818103A

    公开(公告)日：1974-06-18

    申请号：US29635472

    申请日：1972-10-10

    Applicant: ABBOTT LAB

    Inventor： VON ESCH A ,  GEISZLER A

    IPC: A61K31/19 ,  A61K27/00

    CPC classification number: A61K31/19 ,  Y10S514/934

    Abstract: A method of treating herpes simplex infections in animals by administering sulfonoacetic acid or its salts. Although herpes simplex is a very common though minor disease, the only basic treatment presently available is the application of idoxuridine.

    Abstract translation: 一种通过给予磺酰醋酸或其盐治疗动物单纯疱疹感染的方法。

    4.
    发明专利
    未知

    公开(公告)号：BR6457122D0

    公开(公告)日：1973-06-26

    申请号：BR15712264

    申请日：1964-02-26

    Applicant: ABBOTT LAB

    Inventor： VON ESCH A ,  SHERMAN W

    IPC: C07D307/73

    Abstract: The invention comprises 5-nitro-2-furylthioamide and a process for the preparation thereof by heating one molecular proportion of 5-nitro-2-furylnitrile and two molecular proportions of thioacetamide in an inert solvent saturated with hydrogen chloride and recovering the resultant product from the reaction mixture. A thiazole compound of the formula wherein R is methyl or phenyl may be prepared by heating equivalent amounts of 5-nitro-2-furylthioamide and bromoacetone or bromoacetophenone.ALSO:Antifungal and antibacterial compositions contain 5-nitro-2-furylthioamide admixed with an inert carrier, e.g. an inert finely divided solid, water or polyethylene glycol.

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