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    Sulfonyl derivatives of erythromycin
    1.
    发明授权
    Sulfonyl derivatives of erythromycin 失效
    红霉素的磺酰衍生物

    公开(公告)号：US3836519A

    公开(公告)日：1974-09-17

    申请号：US35712173

    申请日：1973-05-04

    Applicant: ABBOTT LAB

    Inventor： HALLAS R ,  MARTIN J ,  TADANIER J

    IPC: A61K31/335 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07C129/18

    CPC classification number: C07H17/08

    Abstract: COVERS SULFONYL DERIVATIVES OF ERHYTHROMYCIN A, B AND C FALLING WITHIN THE FOLLOWING STRUCTURAL FORMULA:

    3,5,7,9,11,13-HEXA(H3C-),4-((2,4-DI(H3C-),3-(R-SO2-O-),

    4-(R1O-)-TETRAHYDROPYRAN-6-YL)-O-),6-((2-(H3C-),

    4-(N(-CH3)2-),5-(R2O-)-TETRAHYDROPYRAN-6-YL)-O-),7,12-

    DI(HO-),13-R3,14-(H5C2-)-OXACYCLOTETRADECANE-2,10-DIONE

    WHERE R IS SELECTED FROM THE ROUP CONSISTING OF LOWERALKYL, LOWERALKENYL, ARYL, SUBSTITUTED ARYL, BENZYL, SUBSTITUTED BENZYL, AROXYALKYL, AND SUBSTITUTED AROXYALKYL; R1 IS HYDROGEN OR METHYL; R2 IS HYDROGEN OR LOWERAKNANOYL AND R3 IS HYDROGEN OR HYDROXYL SAID ERYTHROMYCIN DERIVATIVES BEING USEFUL FOR THIER ANTIBIOTIC ACTIVITY.

    4{41 -o-sulfonyl erythromycin-9-o-oxime derivatives
    2.
    发明授权
    4{41 -o-sulfonyl erythromycin-9-o-oxime derivatives 失效
    4 {41-邻 - 亚甲基红霉素-9-O-氧化衍生物

    公开(公告)号：US3855203A

    公开(公告)日：1974-12-17

    申请号：US35698773

    申请日：1973-05-03

    Applicant: ABBOTT LAB

    Inventor： HALLAS R ,  TADANIER J ,  VON ESCH A

    IPC: A61K31/335 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07C129/18

    CPC classification number: C07H17/08

    Abstract: Covers 4''''-O-sulfonyl erythromycin-9-O-oxime derivatives falling within the following structural formula: WHERE R is selected from the group consisting of loweralkyl, loweralkenyl, aryl, substituted aryl, benzyl and substituted benzyl, R1 is hydrogen or methyl, R2 is hydrogen or loweralkanoyl, R3 is hydrogen or hydroxyl, and R4 is selected from the group consisting of loweralkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, benzyl and substituted benzyl. These 9-O-oxime derivative compounds are useful as antibiotics.

    Abstract translation: 涵盖落在以下结构式中的4“-O-磺酰基红霉素-9-O-肟衍生物：

    SULFONYL DERIVATIVES OF ERYTHROMYCIN
    5.
    发明专利
    SULFONYL DERIVATIVES OF ERYTHROMYCIN 未知

    公开(公告)号：ZA742272B

    公开(公告)日：1975-03-26

    申请号：ZA742272

    申请日：1974-04-09

    Applicant: ABBOTT LAB

    Inventor： TADANIER J ,  HALLAS R ,  MARTIN J

    IPC: A61K31/335 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07C

    Abstract: 1467296 Erythromycin derivatives ABBOTT LABORATORIES 1 May 1974 [4 May 1973] 19163/74 Heading C2C Novel erythromycin derivatives of the general formula wherein R is a C 1-6 alkyl, C 2-6 alkenyl, or optionally nuclear substituted aryl, benzyl or aroxyalkyl group, R 1 is a hydrogen atom or methyl group, R 2 is a hydrogen atom or C 1-6 alkanoyl group and R 3 is a hydrogen atom or hydroxyl group, provided that R 1 and R 3 are not simultaneously a hydrogen atom and the nuclear substituent is nitro, alkyl or halogen are prepared by reacting the corresponding compound in which the -OSO 2 R group is replaced by -OH with RSO 2 Cl (when R is vinyl in the product, R may be 2-bromoethyl in the starting material), followed optionally by hydrolysis or alcoholysis when R 2 is a C 1-6 alkanoyl group to give the corresponding product wherein R 2 is a hydrogen atom. Pharmaceutical compositions having antibiotic activity comprise, as active ingredient, an erythromycin derivative of the above general formula, together with an appropriate carrier.

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