公开(公告)号：US3816397A

公开(公告)日：1974-06-11

申请号：US26305672

申请日：1972-06-15

Applicant: ABBOTT LAB

Inventor： TADANIER J ,  MARTIN J

IPC: C07H17/08 ,  C07C129/18

CPC classification number: C07H17/08

Abstract: COVERS 11, 12-EPOXYERYTHROMYCINS WHICH ARE USEFUL AS ANTIBIOTICS.

公开(公告)号：US3836519A

公开(公告)日：1974-09-17

申请号：US35712173

申请日：1973-05-04

Applicant: ABBOTT LAB

Inventor： HALLAS R ,  MARTIN J ,  TADANIER J

IPC: A61K31/335 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07C129/18

CPC classification number: C07H17/08

Abstract: COVERS SULFONYL DERIVATIVES OF ERHYTHROMYCIN A, B AND C FALLING WITHIN THE FOLLOWING STRUCTURAL FORMULA:

3,5,7,9,11,13-HEXA(H3C-),4-((2,4-DI(H3C-),3-(R-SO2-O-),

4-(R1O-)-TETRAHYDROPYRAN-6-YL)-O-),6-((2-(H3C-),

4-(N(-CH3)2-),5-(R2O-)-TETRAHYDROPYRAN-6-YL)-O-),7,12-

DI(HO-),13-R3,14-(H5C2-)-OXACYCLOTETRADECANE-2,10-DIONE

WHERE R IS SELECTED FROM THE ROUP CONSISTING OF LOWERALKYL, LOWERALKENYL, ARYL, SUBSTITUTED ARYL, BENZYL, SUBSTITUTED BENZYL, AROXYALKYL, AND SUBSTITUTED AROXYALKYL; R1 IS HYDROGEN OR METHYL; R2 IS HYDROGEN OR LOWERAKNANOYL AND R3 IS HYDROGEN OR HYDROXYL SAID ERYTHROMYCIN DERIVATIVES BEING USEFUL FOR THIER ANTIBIOTIC ACTIVITY.

公开(公告)号：US3855203A

公开(公告)日：1974-12-17

申请号：US35698773

申请日：1973-05-03

Applicant: ABBOTT LAB

Inventor： HALLAS R ,  TADANIER J ,  VON ESCH A

IPC: A61K31/335 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07C129/18

CPC classification number: C07H17/08

Abstract: Covers 4''''-O-sulfonyl erythromycin-9-O-oxime derivatives falling within the following structural formula: WHERE R is selected from the group consisting of loweralkyl, loweralkenyl, aryl, substituted aryl, benzyl and substituted benzyl, R1 is hydrogen or methyl, R2 is hydrogen or loweralkanoyl, R3 is hydrogen or hydroxyl, and R4 is selected from the group consisting of loweralkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, benzyl and substituted benzyl. These 9-O-oxime derivative compounds are useful as antibiotics.

Abstract translation: 涵盖落在以下结构式中的4“-O-磺酰基红霉素-9-O-肟衍生物：

公开(公告)号：US3842069A

公开(公告)日：1974-10-15

申请号：US37238773

申请日：1973-06-21

Applicant: ABBOTT LAB

Inventor： JONES P ,  MARTIN J ,  TADANIER J ,  MCALPINE J ,  PAUVLIK J

IPC: C07H17/08 ,  C07C129/18

CPC classification number: C07H17/08

Abstract: 1. A 4"-DEOXY-4"-OXOERYTHROMYCIN COMPOUND SELECTED FROM THE GROUP CONSISTING OF

2,10-DI(O=),4,5,7,9,11,13,-HEXA(H3C-),4-((4,6-DI(H3C-),

4-(H3C-O-),5-(O=),6-(H3C-)-TETRAHYDROPYR-2-YL)-O-),6-

((3-(R1-O-),4-((H3C)2-N-),6-(H3C-)-TETRAHYDROPYR-2-YL)-

O-),7-(HO-),12-(R-O-),14-(H5C2-)-OXACYCLOTETRADECANE

WHERE R IS -CHR2SR3 WHERE R'' IS HYDROGEN OR LOWERALKYL, R3 IS LOWERALKYL AND R1 IS HYDROGEN OR LOWERALKANOYL AND;

2-(O=),3,5,7,9,11,13-HEXA(H3C-),4-((4,6-DI(H3C-),

4-(H3C-O-),5-(O=),6-(H3C-)-TETRAHYDROPYR-2-YL)-O-),6-

((3-(R1-O-),4-((H3C)2-N-),6-(H3C-)-TETRAHYDROPYR-2-YL)-

O-),7,10-(-O-),10,12-(-O-CH(-R2)-O-),12-(H5C2-)-

OXACYCLOTETRADECANE

WHERE R1 AND R2 ARE AS BEFORE DEFINED.

公开(公告)号：US3842068A

公开(公告)日：1974-10-15

申请号：US26308872

申请日：1972-06-15

Applicant: ABBOTT LAB

Inventor： TADANIER J ,  MARTIN J

IPC: C07H17/08 ,  C07C47/18

CPC classification number: C07H17/08

Abstract: 1. AN ERYTHROMYCIN DERIVATIVE SELECTED FROM THE GROUP CONSISTING OF 8-EPI-10,11-ANHYDROETHYTHROMYCN B, 8-EPI11, 12-EPOXYERYTHROMYCIN A 6,9-HEMIACETAL, 8-EPI-ERYTHROMYCIN B AND 8-EPI-10,11-ANHYDROERYTHROMYCIN A.

公开(公告)号：US3828022A

公开(公告)日：1974-08-06

申请号：US26305172

申请日：1972-06-15

Applicant: ABBOTT LAB

Inventor： TADANIER J ,  MARTIN J

IPC: C07H17/08 ,  C07C129/18

CPC classification number: C07H17/08

Abstract: COVER 10,11-ANHYDROERYTHROMYCINS WHICH ARE USEFUL AS ANTIBIOTICS.

公开(公告)号：US3816398A

公开(公告)日：1974-06-11

申请号：US26308772

申请日：1972-06-15

Applicant: ABBOTT LAB

Inventor： TADANIER J ,  MARTIN J

IPC: C07H17/08 ,  C07C129/18

CPC classification number: C07H17/08

Abstract: COVERS 11-0-METHANESULFONYLERYTHROMYCINS WHICH HAVE ANTIBIOTIC ACTIVITY.

公开(公告)号：ZA7403085B

公开(公告)日：1975-05-28

申请号：ZA7403085

申请日：1974-05-14

Applicant: ABBOTT LAB

Inventor： JONES P ,  PAUVLIK J ,  TADANIER J ,  MARTIN J ,  MCALPINE J

IPC: C07H17/08 ,  C07C

CPC classification number: C07H17/08

公开(公告)号：BE885399A

公开(公告)日：1981-03-25

申请号：BE202232

申请日：1980-09-25

Applicant: ABBOTT LAB

Inventor： MARTIN J ,  TADANIER J ,  HALLAS R

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61K31/7042 ,  A61P31/04 ,  C07H15/224 ,  C07H17/00 ,  C07D ,  A61K

公开(公告)号：PH10395A

公开(公告)日：1977-03-04

申请号：PH15865

申请日：1974-05-27

Applicant: ABBOTT LAB

Inventor： JONES P ,  MARTIN J ,  TADANIER J ,  MCALPINE J ,  PAULIK J

IPC: C07H17/08 ,  C07G11/00

Abstract: 1463850 4 11 -Dioxy-4-oxo-erythromycin B derivatives ABBOTT LABORATORIES 19 June 1974 [21 June 1973] 27249/74 Heading C2C Novel compounds I and II in which R 5 is CH(R 7 )-SR 8 (where R 7 is hydrogen or C 1-6 alkyl and R 8 is C 1-6 alkyl) and R 6 is hydrogen or C 2-6 alkanoyl provided that when R 6 is hydrogen then R 5 is also hydrogen are prepared by reacting erythromycin B with a di-C 1-6 alkyl-sulphoxide and C 2-6 alkanoic acid anhydride to form a compound I (R 5 = CH(R 7 )-SR 8 and R 6 = C 2-6 alkanoyl) which is hydrolysed with an alkali metal bicarbonate to form a compound I (R 5 =CH(R 7 )-SR 8 and R 6 = hydrogen) which in the presence of HgO/ HgCl 2 forms a compound II which is hydrolysed by dil. HCl to compound I (R 5 = R 6 = hydrogen). Compound I (R 5 =R 6 =hydrogen) is also prepared by treating compound II with chloramine T.