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公开(公告)号：EP2465856A3
公开(公告)日：2012-12-12
申请号：EP12157739.9
申请日：2007-08-29
Applicant: Abbott Laboratories
Inventor： Klein, Larry, L. , Chen, Hui-Ju , Yeung, Ming, C. , Flentge, Charles, A. , Randolph, John, T. , Huang, Peggy, P. , Hutchinson, Douglas, K. , Kempf, Dale, J.
IPC: C07D277/24 , C07D417/12 , A61K31/427 , A61K31/426 , A61P43/00
CPC classification number: A61K31/5377 , A61K31/4164 , A61K31/4178 , A61K31/4439 , A61K31/4525 , A61K31/496 , A61K31/506 , A61K45/06 , C07D213/79 , C07D277/24 , C07D277/30 , C07D277/593 , C07D417/12
Abstract: The present invention features compounds of formula (I) or pharmaceutically acceptable salts or solvates thereof, for use in inhibiting the metabolizing activities of CYP enzymes and for use in improving the pharmacokinetics of drugs that are metabolized by CYP enzymes.
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公开(公告)号：EP2465856A2
公开(公告)日：2012-06-20
申请号：EP12157739.9
申请日：2007-08-29
Applicant: Abbott Laboratories
Inventor： Klein, Larry, L. , Chen, Hui-Ju , Yeung, Ming, C. , Flentge, Charles, A. , Randolph, John, T. , Huang, Peggy, P. , Hutchinson, Douglas, K. , Kempf, Dale, J.
IPC: C07D277/24 , C07D417/12 , A61K31/427 , A61K31/426 , A61P43/00
CPC classification number: A61K31/5377 , A61K31/4164 , A61K31/4178 , A61K31/4439 , A61K31/4525 , A61K31/496 , A61K31/506 , A61K45/06 , C07D213/79 , C07D277/24 , C07D277/30 , C07D277/593 , C07D417/12
Abstract: The present invention features compounds of formula (I) or pharmaceutically acceptable salts or solvates thereof, for use in inhibiting the metabolizing activities of CYP enzymes and for use in improving the pharmacokinetics of drugs that are metabolized by CYP enzymes.
Abstract translation: 本发明的特征在于式（I）化合物或其药学上可接受的盐或溶剂合物用于抑制CYP酶的代谢活性并用于改善由CYP酶代谢的药物的药代动力学。
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公开(公告)号：EP1315698A1
公开(公告)日：2003-06-04
申请号：EP99917414.7
申请日：1999-04-12
Applicant: ABBOTT LABORATORIES
Inventor： Maring, Clarence J. , Gu, Yu-Gui , Chen, Hui-Ju , Chen, Yuanwei , Degoey, David A. , Flosi, William J. , Giranda, Vincent L. , Grampovnik, David J. , Kati, Warren M. , Kempf, Dale J. , Klein, Larry L. , Krueger, Allan C. , Lin, Zhen , Madigan, Darold L. , McDaniel, Keith F. , Muchmore, Steven W. , Sham, Hing L. , Stewart, Kent D. , Stoll, Vincent S. , Sun, Minghua , Wang, Gary T. , Wang, Sheldon , Xu, Yibo , Yeung, Ming C. , Zhao, Chen , Kennedy, April
IPC: C07D207/16
CPC classification number: C07D207/327 , C07D207/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/04 , C07D417/04 , C07D417/06 , C07F9/5722
Abstract: Disclosed are compounds of formula (I) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
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Patent Agency Ranking
公开(公告)号：EP2216334B1
公开(公告)日：2012-10-31
申请号：EP09176641.0
申请日：2004-11-10
Applicant: Abbott Laboratories
Inventor： Flentge, Charles, A. , Chen, Hui-Ju , Degoey, David, A. , Flosi, William, J. , Grampovnik, David, J. , Huang, Peggy, P. , Kempf, Dale, J. , Klein, Larry, L. , Krueger, Allan, C. , Madigan, Darold, L. , Randolph, John, T. , Sun, Minghua , Yeung, Ming, C. , Zhao, Chen
IPC: C07D417/06 , C07D403/06 , C07D409/06 , C07D401/06 , C07D417/14 , C07D233/72 , C07D405/06 , C07C311/17 , C07D213/40 , C07D277/28 , C07D277/48 , C07D213/78 , C07D493/04 , C07D307/20 , C07D307/42 , A61K31/4178 , A61P31/18 , A61K31/175 , A61K31/277 , A61K45/06
CPC classification number: C07D471/04 , A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D493/04 , A61K2300/00
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公开(公告)号：EP2216334A1
公开(公告)日：2010-08-11
申请号：EP09176641.0
申请日：2004-11-10
Applicant: Abbott Laboratories
Inventor： Flentge, Charles, A. , Chen, Hui-Ju , Degoey, David, A. , Flosi, William, J. , Grampovnik, David, J. , Huang, Peggy, P. , Kempf, Dale, J. , Klein, Larry, L. , Krueger, Allan, C. , Madigan, Darold, L. , Randolph, John, T. , Sun, Minghua , Yeung, Ming, C. , Zhao, Chen
IPC: C07D417/06 , C07D403/06 , C07D409/06 , C07D401/06 , C07D417/14 , C07D233/32 , C07D471/04 , C07D405/10 , C07D403/10 , C07D233/72 , C07D405/06 , C07C311/17 , C07D213/40 , C07D277/28 , C07D277/46 , C07D277/48 , C07D213/78
CPC classification number: C07D471/04 , A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D493/04 , A61K2300/00
Abstract: A compound of the formula
is disclosed as an I-IIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.Abstract translation: 公开了下式的化合物作为I-IIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。
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公开(公告)号：EP2465855A1
公开(公告)日：2012-06-20
申请号：EP12157719.1
申请日：2007-08-29
Applicant: Abbott Laboratories
Inventor： Klein, Larry, L. , Chen, Hui-Ju , Yeung, Ming, C. , Flentge, Charles, A. , Randolph, John, T. , Huang, Peggy, P. , Hutchinson, Douglas, K. , Kempf, Dale, J.
IPC: C07D277/24 , C07D417/12 , A61K31/427 , A61K31/426 , A61P43/00
CPC classification number: A61K31/5377 , A61K31/4164 , A61K31/4178 , A61K31/4439 , A61K31/4525 , A61K31/496 , A61K31/506 , A61K45/06 , C07D213/79 , C07D277/24 , C07D277/30 , C07D277/593 , C07D417/12
Abstract: The present invention features compounds of formula (I) or pharmaceutically acceptable salts, solvates thereof, and compounds of formula (I) for use in inhibiting the metabolizing activities of CYP enzymes. The present invention also features compounds of formula (I) for use in improving the pharmacokinetics of drugs that are metabolized by CYP enzymes.
Abstract translation: 本发明的特征在于用于抑制CYP酶代谢活性的式（I）化合物或其药学上可接受的盐，溶剂化物和式（I）化合物。 本发明的特征还在于用于改善由CYP酶代谢的药物的药代动力学的式（I）的化合物。
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公开(公告)号：EP2264032A3
公开(公告)日：2011-03-23
申请号：EP10176829.9
申请日：2004-11-10
Applicant: Abbott Laboratories
Inventor： Flentge, Charles, A. , Chen, Hui-Ju , Degoey, David, A. , Flosi, William, J. , Grampovnik, David, J. , Huang, Peggy, P. , Kempf, Dale, J. , Klein, Larry, L. , Krueger, Allan, C. , Madigan, Darold, L. , Randolph, John, T. , Sun, Minghua , Yeung, Ming, C. , Zhao, Chen
IPC: C07D417/06 , C07D403/06 , C07D409/06 , C07D401/06 , C07D417/14 , C07D233/32 , C07D471/04 , C07D405/10 , C07D403/10 , C07D233/72 , C07D405/06 , C07C311/17 , C07D213/40 , C07D277/28 , C07D277/46 , C07D277/48 , C07D213/78 , C07D493/04 , C07D307/20 , C07D213/30 , C07D307/42 , A61K31/18 , A61K31/4166 , A61K31/4178 , A61P31/18
CPC classification number: C07D471/04 , A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D493/04 , A61K2300/00
Abstract: A compound of the formula
is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.-
公开(公告)号：EP2264032A2
公开(公告)日：2010-12-22
申请号：EP10176829.9
申请日：2004-11-10
Applicant: Abbott Laboratories
Inventor： Flentge, Charles, A. , Chen, Hui-Ju , Degoey, David, A. , Flosi, William, J. , Grampovnik, David, J. , Huang, Peggy, P. , Kempf, Dale, J. , Klein, Larry, L. , Krueger, Allan, C. , Madigan, Darold, L. , Randolph, John, T. , Sun, Minghua , Yeung, Ming, C. , Zhao, Chen
IPC: C07D417/06 , C07D403/06 , C07D409/06 , C07D401/06 , C07D417/14 , C07D233/32 , C07D471/04 , C07D405/10 , C07D403/10 , C07D233/72 , C07D405/06 , C07C311/17 , C07D213/40 , C07D277/28 , C07D277/46 , C07D277/48 , C07D213/78 , C07D493/04 , C07D307/20 , C07D213/30 , C07D307/42 , A61K31/18 , A61K31/4166 , A61K31/4178 , A61P31/18
CPC classification number: C07D471/04 , A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D493/04 , A61K2300/00
Abstract: A compound of the formula
is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.Abstract translation: 公开了式的化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。
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