公开(公告)号：EP1295874A2

公开(公告)日：2003-03-26

申请号：EP02026856.1

申请日：1996-12-06

Applicant: Abbott Laboratories

Inventor： Sham, Hing Leung ,  Stewart, Kent D. ,  Kempf, Dale, J

IPC: C07D233/32 ,  C07D239/10 ,  C07D239/22 ,  C07D207/40 ,  C07D207/26 ,  C07D241/08 ,  C07D263/22 ,  A61K31/415 ,  A61P31/18

CPC classification number: C07D207/404 ,  C07D207/27 ,  C07D207/408 ,  C07D233/32 ,  C07D233/36 ,  C07D233/42 ,  C07D239/10 ,  C07D239/22 ,  C07D241/08 ,  C07D241/18 ,  C07D253/06 ,  C07D263/22 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12

Abstract: Inhibitors of HIV protease are provided. When bound to HIV protease, the inhibitors are characterized by a unique three-dimensional conformation and orientation relative to the S1, S1', S2, S2', S3, and S3' subsites of the protease. Pharmaceutical compositions containing the inhibitors for treating HIV infection are also provided.

Abstract translation: 提供了HIV蛋白酶的抑制剂。 当与HIV蛋白酶结合时，抑制剂的特征在于相对于蛋白酶的S1，S1'，S2，S2'，S3和S3'亚位的独特的三维构象和取向。 还提供了含有用于治疗HIV感染的抑制剂的药物组合物。

公开(公告)号：EP1315698A1

公开(公告)日：2003-06-04

申请号：EP99917414.7

申请日：1999-04-12

Applicant: ABBOTT LABORATORIES

Inventor： Maring, Clarence J. ,  Gu, Yu-Gui ,  Chen, Hui-Ju ,  Chen, Yuanwei ,  Degoey, David A. ,  Flosi, William J. ,  Giranda, Vincent L. ,  Grampovnik, David J. ,  Kati, Warren M. ,  Kempf, Dale J. ,  Klein, Larry L. ,  Krueger, Allan C. ,  Lin, Zhen ,  Madigan, Darold L. ,  McDaniel, Keith F. ,  Muchmore, Steven W. ,  Sham, Hing L. ,  Stewart, Kent D. ,  Stoll, Vincent S. ,  Sun, Minghua ,  Wang, Gary T. ,  Wang, Sheldon ,  Xu, Yibo ,  Yeung, Ming C. ,  Zhao, Chen ,  Kennedy, April

IPC: C07D207/16

CPC classification number: C07D207/327 ,  C07D207/16 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/06 ,  C07D409/06 ,  C07D413/04 ,  C07D417/04 ,  C07D417/06 ,  C07F9/5722

Abstract: Disclosed are compounds of formula (I) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

公开(公告)号：EP1295874A3

公开(公告)日：2003-04-02

申请号：EP02026856.1

申请日：1996-12-06

Applicant: Abbott Laboratories

Inventor： Sham, Hing Leung ,  Stewart, Kent D. ,  Kempf, Dale, J

IPC: C07D233/32 ,  C07D239/10 ,  C07D239/22 ,  C07D207/40 ,  C07D207/26 ,  C07D241/08 ,  C07D263/22 ,  A61K31/415 ,  A61P31/18

CPC classification number: C07D207/404 ,  C07D207/27 ,  C07D207/408 ,  C07D233/32 ,  C07D233/36 ,  C07D233/42 ,  C07D239/10 ,  C07D239/22 ,  C07D241/08 ,  C07D241/18 ,  C07D253/06 ,  C07D263/22 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12

Abstract: Inhibitors of HIV protease are provided. When bound to HIV protease, the inhibitors are characterized by a unique three-dimensional conformation and orientation relative to the S1, S1', S2, S2', S3, and S3' subsites of the protease. Pharmaceutical compositions containing the inhibitors for treating HIV infection are also provided.

公开(公告)号：EP2535336A1

公开(公告)日：2012-12-19

申请号：EP12163093.3

申请日：2007-10-19

Applicant: Abbott GmbH & Co. KG ,  Abbott Laboratories

Inventor： Turner, Sean Colm ,  Bakker, Margaretha Henrica Maria ,  Stewart, Kent D.

IPC: C07D401/12 ,  C07D413/14 ,  C07D471/04 ,  A61K31/4709 ,  A61K31/497 ,  A61P25/00

CPC classification number: C07D401/12 ,  C07D241/20 ,  C07D413/14 ,  C07D471/04

Abstract: The present invention relates to a heterocyclic compound of the general formula (I)

and their use and preparation, methods of making the compounds, compositions containing at least one of said compounds, and methods of treatment using at least one compound. In particular, compounds of the general formula (I) are useful for inhibiting glycogen synthase kinase 3 (GSK-3),

Abstract translation: 本发明涉及通式（I）的杂环化合物及其用途和制备方法，制备该化合物的方法，含有至少一种所述化合物的组合物和使用至少一种化合物的治疗方法。 特别地，通式（I）的化合物可用于抑制糖原合成酶激酶3（GSK-3），