公开(公告)号：EP1315698A1

公开(公告)日：2003-06-04

申请号：EP99917414.7

申请日：1999-04-12

Applicant: ABBOTT LABORATORIES

Inventor： Maring, Clarence J. ,  Gu, Yu-Gui ,  Chen, Hui-Ju ,  Chen, Yuanwei ,  Degoey, David A. ,  Flosi, William J. ,  Giranda, Vincent L. ,  Grampovnik, David J. ,  Kati, Warren M. ,  Kempf, Dale J. ,  Klein, Larry L. ,  Krueger, Allan C. ,  Lin, Zhen ,  Madigan, Darold L. ,  McDaniel, Keith F. ,  Muchmore, Steven W. ,  Sham, Hing L. ,  Stewart, Kent D. ,  Stoll, Vincent S. ,  Sun, Minghua ,  Wang, Gary T. ,  Wang, Sheldon ,  Xu, Yibo ,  Yeung, Ming C. ,  Zhao, Chen ,  Kennedy, April

IPC: C07D207/16

CPC classification number: C07D207/327 ,  C07D207/16 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/06 ,  C07D409/06 ,  C07D413/04 ,  C07D417/04 ,  C07D417/06 ,  C07F9/5722

Abstract: Disclosed are compounds of formula (I) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

公开(公告)号：EP2336138A2

公开(公告)日：2011-06-22

申请号：EP10184668.1

申请日：2005-06-29

Applicant: ABBOTT LABORATORIES

Inventor： Degoey, DAvid A ,  Flosi, William J ,  Grampovnik, David J. ,  Klein, Larry L. ,  Kempf, Dale J. ,  Wang, Xiu C.

IPC: C07F9/09 ,  A61K31/661 ,  A61P35/00

CPC classification number: A61K45/06 ,  A61K31/661 ,  A61K2300/00

Abstract: A compound of the formula I, II or III is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions of inhibiting HIV protease activity and treating HIV infection are also disclosed.

Abstract translation: 公开了式I，II或III的化合物作为HIV蛋白酶抑制剂的前药。 还公开了抑制HIV蛋白酶活性和治疗HIV感染的方法和组合物。

公开(公告)号：EP2336138A3

公开(公告)日：2011-11-16

申请号：EP10184668.1

申请日：2005-06-29

Applicant: ABBOTT LABORATORIES

Inventor： Degoey, DAvid A ,  Flosi, William J ,  Grampovnik, David J. ,  Klein, Larry L. ,  Kempf, Dale J. ,  Wang, Xiu C.

IPC: C07F9/09 ,  A61K31/661 ,  A61P35/00

CPC classification number: A61K45/06 ,  A61K31/661 ,  A61K2300/00

Abstract: A compound of the formula I, II or III is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions of inhibiting HIV protease activity and treating HIV infection are also disclosed.