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公开(公告)号：EP0353591A3
公开(公告)日：1991-03-20
申请号：EP89113616.0
申请日：1989-07-24
Applicant: ABBOTT LABORATORIES
Inventor： Defreese, James Douglas , Huang, Tung-Ming , Holen, James T. , Gray, Robert Carlton , Bailey, Mark Wallace , Donohue, Joseph Patrick , Putterman, Caryn Glickson
CPC classification number: G01N33/5302 , G01J2001/161 , G01J2001/1636 , G01N21/253 , G01N35/00029 , G01N2021/0162 , G01N2021/478 , G01N2035/00099 , G01N2035/00752 , G01N2035/1025 , G01N2201/0415 , G01N2201/069 , G01N2201/12761
Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carousel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer contained within a reaction well which is adapted to contain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is positioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.
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Patent Agency Ranking
公开(公告)号：EP0353589B1
公开(公告)日：1996-02-07
申请号：EP89113614.5
申请日：1989-07-24
Applicant: ABBOTT LABORATORIES
CPC classification number: G01N35/1009 , B01L3/545 , G01N21/8483 , G01N35/00712 , G01N35/00732 , G01N2021/478 , G01N2035/00752 , G01N2035/00762 , G01N2035/1025 , G01N2035/1086 , G01N2201/12753
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3.发明公开Apparatus and method for providing assay calibration data 失效Verfahren und Vorrichtung zum Erzeugen von Eichdatenfürdie Analyze。
公开(公告)号：EP0353589A2
公开(公告)日：1990-02-07
申请号：EP89113614.5
申请日：1989-07-24
Applicant: ABBOTT LABORATORIES
CPC classification number: G01N35/1009 , B01L3/545 , G01N21/8483 , G01N35/00712 , G01N35/00732 , G01N2021/478 , G01N2035/00752 , G01N2035/00762 , G01N2035/1025 , G01N2035/1086 , G01N2201/12753
Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carousel (18) is provided to position and hold a plurality of reaction cartridges (80). Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer contained within a reaction well (86) which is adapted to contain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is positioned uniformly. An optical reader (32) operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.
Abstract translation: 提供半自动化生物样品分析仪和子系统，以同时对多个生物样品中的每一个中预先选择的过敏原的一组特异性的himan IgE类抗体进行多次酶免疫测定。 提供转盘（18）以定位和保持多个反应盒（80）。 每个反应筒包括在包含在反应井（86）内的固相结合层中的二维阵列中形成的多个分离的测试位点，其适于容纳要测定的生物样品。 圆盘传送带和墨盒包含结构，其配合以将墨盒精确地定位在三个分开的尺寸中的每一个中，使得每个墨盒均匀地定位。 提供以漫反射原理工作的光学阅读器（32），以从每个盒的每个测试位置读取测定结果。 还提供了一种子系统，其提供预定的特异性测定校准数据，其可用于相对于预定的共同标准值标准化各种测定的结果。
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公开(公告)号：EP0353591B1
公开(公告)日：1996-04-17
申请号：EP89113616.0
申请日：1989-07-24
Applicant: ABBOTT LABORATORIES
Inventor： Defreese, James Douglas , Huang, Tung-Ming , Holen, James T. , Gray, Robert Carlton , Bailey, Mark Wallace , Donohue, Joseph Patrick , Putterman, Caryn Glickson
CPC classification number: G01N33/5302 , G01J2001/161 , G01J2001/1636 , G01N21/253 , G01N35/00029 , G01N2021/0162 , G01N2021/478 , G01N2035/00099 , G01N2035/00752 , G01N2035/1025 , G01N2201/0415 , G01N2201/069 , G01N2201/12761
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公开(公告)号：EP0353589A3
公开(公告)日：1991-03-13
申请号：EP89113614.5
申请日：1989-07-24
Applicant: ABBOTT LABORATORIES
CPC classification number: G01N35/1009 , B01L3/545 , G01N21/8483 , G01N35/00712 , G01N35/00732 , G01N2021/478 , G01N2035/00752 , G01N2035/00762 , G01N2035/1025 , G01N2035/1086 , G01N2201/12753
Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carousel (18) is provided to position and hold a plurality of reaction cartridges (80). Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer contained within a reaction well (86) which is adapted to contain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is positioned uniformly. An optical reader (32) operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.
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公开(公告)号：EP0353591A2
公开(公告)日：1990-02-07
申请号：EP89113616.0
申请日：1989-07-24
Applicant: ABBOTT LABORATORIES
Inventor： Defreese, James Douglas , Huang, Tung-Ming , Holen, James T. , Gray, Robert Carlton , Bailey, Mark Wallace , Donohue, Joseph Patrick , Putterman, Caryn Glickson
CPC classification number: G01N33/5302 , G01J2001/161 , G01J2001/1636 , G01N21/253 , G01N35/00029 , G01N2021/0162 , G01N2021/478 , G01N2035/00099 , G01N2035/00752 , G01N2035/1025 , G01N2201/0415 , G01N2201/069 , G01N2201/12761
Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carousel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer contained within a reaction well which is adapted to contain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is positioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.
Abstract translation: 提供半自动化生物样品分析仪和子系统，以同时对多个生物样品中的每一个中预先选择的过敏原的一组特异性的himan IgE类抗体进行多次酶免疫测定。 提供转盘以定位和保持多个反应盒。 每个反应盒包括在包含在反应井内的固相结合层中的二维阵列中形成的多个分离的测试位点，其适于含有要测定的生物样品。 圆盘传送带和墨盒包含结构，其配合以将墨盒精确地定位在三个分开的尺寸中的每一个中，使得每个墨盒均匀地定位。 提供以漫反射原理工作的光学阅读器，以从每个盒的每个测试位置读取测定结果。 还提供了一种子系统，其提供预定的特异性测定校准数据，其可用于相对于预定的共同标准值标准化各种测定的结果。
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