公开(公告)号：EP0831330A3

公开(公告)日：1998-08-12

申请号：EP97116256.5

申请日：1997-09-18

Applicant: Abbott Laboratories

Inventor： Arnquist, David C. ,  Barnes III,Grady ,  Dunn, Chadwick M. ,  East Jr.,Richard C. ,  Fritchie, Patrick P. ,  Gardner, Gregory E. ,  Grandone, Cass J. ,  Gray, Robert C. ,  Holen, James T. ,  McCoy, Jimmy D. ,  Mitchell, James E. ,  Murray, Adrian J. ,  Murray, David W. ,  Ramsey, Jack F. ,  Sleszynski, Neal T.

IPC: G01N35/04

CPC classification number: B01L3/508 ,  B01L2300/0851 ,  G01N21/76 ,  G01N35/0092 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/00534 ,  G01N2035/00752 ,  G01N2035/0465 ,  G01N2035/0467

Abstract: Embodiments described herein provide methods of performing a process for determining an item of interest in a sample. In one embodiment, a container for holding the sample is accepted in a process lane where a process step is selectively automatically performed on the sample in the container. The process step is selectively automatically performed on the sample in the container. A physical length of the process lane is selectively varied.

公开(公告)号：EP0353592B1

公开(公告)日：1996-04-24

申请号：EP89113617.8

申请日：1989-07-24

Applicant: ABBOTT LABORATORIES

Inventor： Holen, James T. ,  Hicaro, Enrique, Jr. ,  Putterman, Caryn Glickson ,  Huang, Tung-Ming ,  Merkh, Carl Walter

IPC: G01N35/02 ,  B01L3/00

CPC classification number: B01L3/508 ,  B01L2200/025 ,  B01L2300/021 ,  B01L2300/044 ,  B01L2300/0809 ,  G01N35/025 ,  G01N2035/00752 ,  G01N2035/1025 ,  G06F19/00

Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carousel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer contained within a reaction well which is adapted to contain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is positioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.

公开(公告)号：EP0353592A2

公开(公告)日：1990-02-07

申请号：EP89113617.8

申请日：1989-07-24

Applicant: ABBOTT LABORATORIES

Inventor： Holen, James T. ,  Hicaro, Enrique, Jr. ,  Putterman, Caryn Glickson ,  Huang, Tung-Ming ,  Merkh, Carl Walter

IPC: G01N35/02 ,  B01L3/00

CPC classification number: B01L3/508 ,  B01L2200/025 ,  B01L2300/021 ,  B01L2300/044 ,  B01L2300/0809 ,  G01N35/025 ,  G01N2035/00752 ,  G01N2035/1025 ,  G06F19/00

Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carou­sel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer con­tained within a reaction well which is adapted to con­tain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is posi­tioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.

Abstract translation: 提供半自动化生物样品分析仪和子系统，以同时对多个生物样品中的每一个中预先选择的过敏原的一组特异性的himan IgE类抗体进行多次酶免疫测定。 提供转盘以定位和保持多个反应盒。 每个反应盒包括在包含在反应井内的固相结合层中的二维阵列中形成的多个分离的测试位点，其适于含有要测定的生物样品。 圆盘传送带和墨盒包含结构，其配合以将墨盒精确地定位在三个分开的尺寸中的每一个中，使得每个墨盒均匀地定位。 提供以漫反射原理工作的光学阅读器，以从每个盒的每个测试位置读取测定结果。 还提供了一种子系统，其提供预定的特异性测定校准数据，其可用于相对于预定的共同标准值标准化各种测定的结果。

公开(公告)号：EP0831330B1

公开(公告)日：2005-12-14

申请号：EP97116256.5

申请日：1997-09-18

Applicant: ABBOTT LABORATORIES

Inventor： Arnquist, David C. ,  Barnes III,Grady ,  Dunn, Chadwick M. ,  East Jr.,Richard C. ,  Fritchie, Patrick P. ,  Gardner, Gregory E. ,  Grandone, Cass J. ,  Gray, Robert C. ,  Holen, James T. ,  McCoy, Jimmy D. ,  Mitchell, James E. ,  Murray, Adrian J. ,  Murray, David W. ,  Ramsey, Jack F. ,  Sleszynski, Neal T.

IPC: G01N35/04

CPC classification number: B01L3/508 ,  B01L2300/0851 ,  G01N21/76 ,  G01N35/0092 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/00534 ,  G01N2035/00752 ,  G01N2035/0465 ,  G01N2035/0467

公开(公告)号：EP0160282B1

公开(公告)日：1990-01-17

申请号：EP85105106.0

申请日：1985-04-26

Applicant: ABBOTT LABORATORIES

Inventor： Holen, James T.

IPC: G01N21/07 ,  B04B5/04

CPC classification number: G01N21/07 ,  B04B5/0407

公开(公告)号：EP0160282A3

公开(公告)日：1986-03-05

申请号：EP85105106

申请日：1985-04-26

Applicant: ABBOTT LABORATORIES

Inventor： Holen, James T.

IPC: G01N21/07 ,  B04B05/04

CPC classification number: G01N21/07 ,  B04B5/0407

Abstract: A sample processor card for use with a centrifuge in which the direction of centrifugal force can be altered at will, wherein the card includes a supply of chemical reagent and inlet means for supplying a chemical sample to the card. The sample is advanced under centrifugal force through capillary means to sample measuring means, and the measured sample is then mixed with reagent to permit a chemical test to be carried out on the reagent, all under centrifugal force.

公开(公告)号：EP0898171A1

公开(公告)日：1999-02-24

申请号：EP98120632.9

申请日：1997-08-20

Applicant: Abbott Laboratories

Inventor： Arnquist, David C. ,  Barnes III, Grady ,  Button, Richard D. ,  Dunn, Chadwick M. ,  East, Jr., Richard C. ,  Fritchie, Patrick P. ,  Galitz, Charles M. ,  Grandone, Cass J. ,  Gardner, Gregory E. ,  Gray, Robert C. ,  Holen, James T. ,  Luoma II, Robert P. ,  McCory, Jimmy D. ,  Mitchell, James E. ,  Murray, Adrian John ,  Murray, David W. ,  Ramsey, Jack F. ,  Sleszynski, Neal T. ,  Toth, Julius J.

IPC: G01N35/04

CPC classification number: B01L3/508 ,  B01L2300/0851 ,  G01N21/76 ,  G01N35/0092 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/00534 ,  G01N2035/00752 ,  G01N2035/0465 ,  G01N2035/0467

Abstract: The invention relates a method of constructing at least a first structure and a second structure both for determining an item of interest in a sample, the method comprising the steps of:

(a) defining an effective length representing a total distance traveled by a reaction container during determination of an item of interest in a sample;
(b) constructing the first structure for determining an item of interest in a sample, the first structure having a first process lane having a first physical length and a first means for moving the reaction container the effective length along the first process lane during determination of an item of interest in a sample disposed within the reaction container; and
(c) constructing the second structure for determining an item of interest in a sample, the second structure having a second process lane having a second physical length different from the first physical length and a second means for moving the reaction container the effective length along the second process lane during determination of an item of interest in sample disposed within the reaction container.

Abstract translation: 本发明涉及一种构建至少第一结构和第二结构的方法，用于确定样品中的感兴趣物品，该方法包括以下步骤：（a）限定代表由反应容器行进的总距离的有效长度 在确定样品中感兴趣的物品时; （b）构建用于确定样品中的感兴趣物品的第一结构，所述第一结构具有第一物理长度的第一处理通道和用于在确定期间沿着第一处理通道移动反应容器的有效长度的第一装置 在反应容器内设置的样品中的感兴趣物品; 和（c）构建用于确定样品中的感兴趣物品的第二结构，所述第二结构具有具有不同于第一物理长度的第二物理长度的第二处理通道，以及用于使反应容器移动有效长度的第二装置 在确定设置在反应容器内的样品中的感兴趣物品的第二过程车道。

公开(公告)号：EP0864866A1

公开(公告)日：1998-09-16

申请号：EP97116257.3

申请日：1997-09-18

Applicant: ABBOTT LABORATORIES

Inventor： Arnquist, David C. ,  Barnes, Grady, III ,  Dunn, Chadwick M. ,  East,Jr. Richard C. ,  Fritchie, Patrick P. ,  Gardner, Gregory E. ,  Grandone, Cass J. ,  Gray, Robert C. ,  Holen, James T. ,  McCoy, Jimmy D. ,  Mitchell, James E. ,  Murray, Adrian J. ,  Murray, David W. ,  Ramsey, Jack F. ,  Sleszynski, Neal T.

IPC: G01N35/04

CPC classification number: G01N35/04 ,  G01N35/0092 ,  G01N35/025 ,  G01N2035/00534 ,  G01N2035/00752 ,  G01N2035/0465 ,  G01N2035/0467

Abstract: Methods of constructing a structure for determining an item of interest in a sample are provided. According to one method, an effective length of movement of a container (15) for holding the sample in a process lane (28) where a process step is selectively automatically performed on the sample in the container (15) is determined. The process lane (28) is constructed such that the process lane (28) meets at least one of a predetermined throughput and a predetermined physical dimension. Elements are arranged along the process lane (28) such that the container (15) moves the effective length during performance of a determination of an item of interest.

Abstract translation: 提供了构建用于确定样本中的感兴趣项目的结构的方法。 根据一种方法，确定用于将样品保持在处理通道（28）中的容器（15）的有效运动长度，其中在容器（15）中的样品上选择性地自动执行处理步骤。 过程车道（28）被构造成使得过程车道（28）满足预定吞吐量和预定物理尺寸中的至少一个。 沿着过程车道（28）布置元件，使得容器（15）在执行感兴趣物品的确定期间移动有效长度。

公开(公告)号：EP0831329A3

公开(公告)日：1998-08-12

申请号：EP97114411.8

申请日：1997-08-20

Applicant: Abbott Laboratories

Inventor： Arnquist, David C. ,  Barnes, Grady, III ,  Button, Richard D. ,  Dunn, Chadwick M. ,  East, Richard C., Jr. ,  Fritchie, Patrick P. ,  Galitz, Charles M. ,  Grandone, Cass J. ,  Gardner, Gregory E. ,  Gray, Robert C. ,  Holen, James T. ,  Luoma, Robert P., II ,  McCory, Jimmy D. ,  Mitchell, James E. ,  Murray, Adrian John ,  Murray, David W. ,  Ramsey, Jack F. ,  Sleszynski, Neal T. ,  Toth, Julius J.

IPC: G01N35/04

CPC classification number: B01L3/508 ,  B01L2300/0851 ,  G01N21/76 ,  G01N35/0092 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/00534 ,  G01N2035/00752 ,  G01N2035/0465 ,  G01N2035/0467

Abstract: The structure embodiments disclosed relate to determination of an item of interest in a sample. One embodiment relates to a structure which comprises a process path (10). The process path (10) comprises a process lane (28) including a process step performance lane (62) where a process step is performed, and a process step avoidance lane (64) where the process step is avoided. A first prime mover (24) is operatively connected with the process path (10) for moving a container (15) holding the sample along the process path (10). A first pipetting system (198) is operatively associated with the process path (10) for introducing the sample to the container (15). A second pipetting system (132, 134) is operatively associated with the process path (10) for introducing a reagent to the container (15). A device (86) is operatively connected with the process path (10) and is selectively engagable with the container (15) for mixing the sample and the reagent in the container (15). A second prime mover (44) is operatively connected with the process path (10) for selectively positioning the container (15) in a selected one of the process step performance lane (62) and the process step avoidance lane (64). A reader (138) is operatively connected with the process path (10) for determining the item of interest in the sample based upon a reaction between the sample and the reagent. The method embodiments disclosed relate to determination of an item of interest in a sample. In one method, a process path (10) comprising a process lane (28) including a process step performance lane (62) where a process step is performed, and a process step avoidance lane (64) where the process step is avoided is provided. A container (15) holding the sample is moved along the process path (10). The sample is introduced to the container (15). A reagent is introduced to the container (15). The sample and the reagent are mixed in the container (15). The container (15) is selectively positioned in a selected one of the process step performance lane (62) and the process step avoidance lane (64). The item of interest in the sample is determined based upon a reaction between the sample and the reagent.

Abstract translation: 所公开的结构实施例涉及确定样本中的感兴趣项目。 一个实施例涉及一种包括处理路径（10）的结构。 处理路径（10）包括处理通道（28），处理通道（28）包括执行处理步骤的处理步骤执行通道（62）和避免处理步骤的处理步骤避免通道（64）。 第一原动机（24）与处理路径（10）可操作地连接，用于沿着处理路径（10）移动容纳样品的容器（15）。 第一移液系统（198）可操作地与处理路径（10）相关联以将样品引入容器（15）。 第二移液系统（132,134）与处理路径（10）可操作地相关联以将试剂引入容器（15）。 装置（86）与处理路径（10）可操作地连接，并可选择性地与容器（15）接合，以将样品和试剂混合在容器（15）中。 第二原动机（44）与处理路径（10）可操作地连接，用于将容器（15）选择性地定位在处理步骤性能通道（62）和处理步骤避免通道（64）中的选定的一个中。 读取器（138）与处理路径（10）可操作地连接，用于基于样本与试剂之间的反应来确定样本中的感兴趣项目。 所公开的方法实施例涉及确定样本中的感兴趣项目。 在一种方法中，提供包括处理通道（28）的处理路径（10），该处理通道包括执行处理步骤的处理步骤执行通道（62）和避免处理步骤的处理步骤避免通道（64） 。 保持样品的容器（15）沿着处理路径（10）移动。 样品被引入容器（15）。 试剂被引入容器（15）。 样品和试剂在容器（15）中混合。 容器（15）选择性地定位在处理步骤执行通道（62）和处理步骤回避通道（64）中选定的一个中。 样品中感兴趣的项目是基于样品和试剂之间的反应来确定的。

公开(公告)号：EP0353592A3

公开(公告)日：1991-05-29

申请号：EP89113617.8

申请日：1989-07-24

Applicant: ABBOTT LABORATORIES

Inventor： Holen, James T. ,  Hicaro, Enrique, Jr. ,  Putterman, Caryn Glickson ,  Huang, Tung-Ming ,  Merkh, Carl Walter

IPC: G01N35/02 ,  B01L3/00

CPC classification number: B01L3/508 ,  B01L2200/025 ,  B01L2300/021 ,  B01L2300/044 ,  B01L2300/0809 ,  G01N35/025 ,  G01N2035/00752 ,  G01N2035/1025 ,  G06F19/00

Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carou­sel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer con­tained within a reaction well which is adapted to con­tain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is posi­tioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.