公开(公告)号：WO2004041818A1

公开(公告)日：2004-05-21

申请号：PCT/US2003/034707

申请日：2003-10-31

Applicant: ABBOTT LABORATORIES

Inventor： PRATT, John, K. ,  BETEBENNER, David, A. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  MCDANIEL, Keith, F. ,  MARING, Clarence, J. ,  STOLL, Vincent, S. ,  ZHANG, Rong

IPC: C07D471/04

CPC classification number: C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.

Abstract translation: 本发明提供具有式（I）的HCV聚合酶抑制化合物和包含治疗有效量的所述化合物的组合物。 本发明还提供抑制丙型肝炎病毒（HCV）聚合酶的方法，抑制HCV病毒复制的方法，以及治疗或预防HCV感染的方法。 还提供了用于制备所述化合物的方法和在所述方法中使用的合成中间体。

公开(公告)号：WO2007081517A2

公开(公告)日：2007-07-19

申请号：PCT/US2006/048685

申请日：2006-12-20

Applicant: ABBOTT LABORATORIES ,  BETEBENNER, David, A. ,  DEGOEY, David, A. ,  MARING, Clarence, J. ,  KRUEGER, Allan, C. ,  IWASAKI, Nobuhiko ,  ROCKWAY, Todd, W. ,  COOPER, Curt, S. ,  ANDERSON, David, D. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  LIU, Dachun ,  MCDANIEL, Keith, F. ,  MADIGAN, Darold, L. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  SHANLEY, Jason, P. ,  TUFANO, Michael, D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami, J. ,  MASSE, Sherie, VL. ,  CARRICK, Robert, J. ,  HE, Weping ,  LU, Liangjun ,  GRAMPOVNIK, David, J.

Inventor： BETEBENNER, David, A. ,  DEGOEY, David, A. ,  MARING, Clarence, J. ,  KRUEGER, Allan, C. ,  IWASAKI, Nobuhiko ,  ROCKWAY, Todd, W. ,  COOPER, Curt, S. ,  ANDERSON, David, D. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  LIU, Dachun ,  MCDANIEL, Keith, F. ,  MADIGAN, Darold, L. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  SHANLEY, Jason, P. ,  TUFANO, Michael, D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami, J. ,  MASSE, Sherie, VL. ,  CARRICK, Robert, J. ,  HE, Weping ,  LU, Liangjun ,  GRAMPOVNIK, David, J.

IPC: C07D495/04 ,  C07D471/04 ,  C07D513/04

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D475/06 ,  C07D495/04 ,  C07D513/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：WO2007076034A2

公开(公告)日：2007-07-05

申请号：PCT/US2006/049079

申请日：2006-12-20

Applicant: ABBOTT LABORATORIES ,  BETEBENNER, David, A. ,  DEGOEY, David, A. ,  MARING, Clarence, J. ,  KRUEGER, Allan, C. ,  IWASAKI, Nobuhiko ,  ROCKWAY, Todd, W. ,  COOPER, Curt, S. ,  ANDERSON, David, D. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  LIU, Dachun ,  MCDANIEL, Keith, F. ,  MADIGAN, Darold, L. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  SHANLEY, Jason, P. ,  TUFANO, Michael, D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami, J. ,  MASSE, Sherie, VL. ,  CARRICK, Robert, J. ,  HE, Weping ,  LU, Liangjun ,  GRAMPOVNIK, David, J.

Inventor： BETEBENNER, David, A. ,  DEGOEY, David, A. ,  MARING, Clarence, J. ,  KRUEGER, Allan, C. ,  IWASAKI, Nobuhiko ,  ROCKWAY, Todd, W. ,  COOPER, Curt, S. ,  ANDERSON, David, D. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  LIU, Dachun ,  MCDANIEL, Keith, F. ,  MADIGAN, Darold, L. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  SHANLEY, Jason, P. ,  TUFANO, Michael, D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami, J. ,  MASSE, Sherie, VL. ,  CARRICK, Robert, J. ,  HE, Weping ,  LU, Liangjun ,  GRAMPOVNIK, David, J.

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

Abstract translation: 公开了有效抑制丙型肝炎病毒（“HCV”）或其它病毒复制的化合物。 本发明还涉及包含此类化合物的组合物，此类化合物与其他抗病毒剂或治疗剂的共同配制或共同施用，用于合成此类化合物的方法和中间体，以及使用此类化合物治疗 HCV或其他病毒感染。

公开(公告)号：WO2005019191A2

公开(公告)日：2005-03-03

申请号：PCT/US2004/027000

申请日：2004-08-19

Applicant: ABBOTT LABORATORIES ,  HUTCHINSON, Douglas, K. ,  BELLETTINI, John, R. ,  BETEBENNER, David, A. ,  BISHOP, Richard, D. ,  BORCHARDT, Thomas, B. ,  BOSSE, Todd, D. ,  CINK, Russell, D. ,  FLENTGE, Charles, A. ,  GATES, Bradley, D. ,  GREEN, Brian, E. ,  HINMAN, Mira, M. ,  HUANG, Peggy, P. ,  KLEIN, Larry, L. ,  KRUEGER, Allan, C. ,  LARSON, Daniel, P. ,  LEANNA, M., Robert ,  LIU, Dachun ,  MADIGAN, Darold, L. ,  MCDANIEL, Keith, F. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  ROSENBERG, Teresa, A. ,  STEWART, Kent, D. ,  STOLL, Vincent, S. ,  WAGNER, Rolf ,  YEUNG, Ming, C.

Inventor： HUTCHINSON, Douglas, K. ,  BELLETTINI, John, R. ,  BETEBENNER, David, A. ,  BISHOP, Richard, D. ,  BORCHARDT, Thomas, B. ,  BOSSE, Todd, D. ,  CINK, Russell, D. ,  FLENTGE, Charles, A. ,  GATES, Bradley, D. ,  GREEN, Brian, E. ,  HINMAN, Mira, M. ,  HUANG, Peggy, P. ,  KLEIN, Larry, L. ,  KRUEGER, Allan, C. ,  LARSON, Daniel, P. ,  LEANNA, M., Robert ,  LIU, Dachun ,  MADIGAN, Darold, L. ,  MCDANIEL, Keith, F. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  ROSENBERG, Teresa, A. ,  STEWART, Kent, D. ,  STOLL, Vincent, S. ,  WAGNER, Rolf ,  YEUNG, Ming, C.

IPC: C07D285/00

CPC classification number: C07D417/12 ,  C07D285/24 ,  C07D285/30 ,  C07D513/04

Abstract: Compounds having the formula (I) are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.

Abstract translation: 具有式（I）的化合物是丙型肝炎（HCV）聚合酶抑制剂。 还公开了用于抑制丙型肝炎（HCV）聚合酶的组合物和方法，用于制备化合物的方法和在该方法中使用的合成中间体。

公开(公告)号：WO2011156337A2

公开(公告)日：2011-12-15

申请号：PCT/US2011/039397

申请日：2011-06-07

Applicant: ABBOTT LABORATORIES ,  ENANTA PHARMACEUTICALS, INC. ,  CHEN, Hui-ju ,  MCDANIEL, Keith, F. ,  GREEN, Brian, E. ,  SHANLEY, Jason, P. ,  KRUGER, Albert, W. ,  GANDARILLA, Jorge ,  WELCH, Dennie, S. ,  CINK, Russell, D. ,  GAI, Yonghua ,  WANG, Guoqiang ,  OR, Yat, Sun

Inventor： CHEN, Hui-ju ,  MCDANIEL, Keith, F. ,  GREEN, Brian, E. ,  SHANLEY, Jason, P. ,  KRUGER, Albert, W. ,  GANDARILLA, Jorge ,  WELCH, Dennie, S. ,  CINK, Russell, D. ,  GAI, Yonghua ,  WANG, Guoqiang ,  OR, Yat, Sun

IPC: C07D487/04 ,  A61K31/407 ,  A61K31/498 ,  A61P31/14

CPC classification number: C07K5/081 ,  C07D487/04

Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

Abstract translation: 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。

公开(公告)号：EP1979348A2

公开(公告)日：2008-10-15

申请号：EP06848055.7

申请日：2006-12-20

Applicant: ABBOTT LABORATORIES

Inventor： BETEBENNER, David, A. ,  DEGOEY, David, A. ,  MARING, Clarence, J. ,  KRUEGER, Allan, C. ,  IWASAKI, Nobuhiko ,  ROCKWAY, Todd, W. ,  COOPER, Curt, S. ,  ANDERSON, David, D. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  LIU, Dachun ,  MCDANIEL, Keith,F. ,  MADIGAN, Darold, L. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  SHANLEY, Jason, P. ,  TUFANO, Michael, D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami, J. ,  MASSE, Sherie, VL. ,  CARRICK, Robert, J. ,  HE, Weping ,  LU, Liangjun ,  GRAMPOVNIK, David, J.

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ('HCV') or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：EP1560827B1

公开(公告)日：2010-12-29

申请号：EP03768559.1

申请日：2003-10-31

Applicant: ABBOTT LABORATORIES

Inventor： PRATT, John, K. ,  BETEBENNER, David, A. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  MCDANIEL, Keith, F. ,  MARING, Clarence, J. ,  STOLL, Vincent, S. ,  ZHANG, Rong

IPC: C07D471/04 ,  C07D513/04 ,  C07D519/00 ,  C07D495/04 ,  C07D417/04 ,  C07D513/14 ,  C07D417/14 ,  A61K31/554 ,  A61P31/00 ,  C07D215/22 ,  C07D401/04 ,  C07D213/69

CPC classification number: C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.

公开(公告)号：EP1979348B1

公开(公告)日：2012-01-18

申请号：EP06848055.7

申请日：2006-12-20

Applicant: ABBOTT LABORATORIES

Inventor： BETEBENNER, David, A. ,  DEGOEY, David, A. ,  MARING, Clarence, J. ,  KRUEGER, Allan, C. ,  IWASAKI, Nobuhiko ,  ROCKWAY, Todd, W. ,  COOPER, Curt, S. ,  ANDERSON, David, D. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  LIU, Dachun ,  MCDANIEL, Keith,F. ,  MADIGAN, Darold, L. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  SHANLEY, Jason, P. ,  TUFANO, Michael, D. ,  WAGNER, Rolf ,  ZHANG, Rong ,  MOLLA, Akhteruzzaman ,  MO, Hongmei ,  PILOT-MATIAS, Tami, J. ,  MASSE, Sherie, VL. ,  CARRICK, Robert, J. ,  HE, Weping ,  LU, Liangjun ,  GRAMPOVNIK, David, J.

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ('HCV') or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：EP1560827A1

公开(公告)日：2005-08-10

申请号：EP03768559.1

申请日：2003-10-31

Applicant: Abbott Laboratories

Inventor： PRATT, John, K. ,  BETEBENNER, David, A. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  MCDANIEL, Keith, F. ,  MARING, Clarence, J. ,  STOLL, Vincent, S. ,  ZHANG, Rong

IPC: C07D471/04 ,  C07D513/04 ,  C07D519/00 ,  C07D495/04 ,  C07D417/04 ,  C07D513/14 ,  C07D417/14 ,  A61K31/554 ,  A61P31/00 ,  C07D215/22 ,  C07D401/04 ,  C07D213/69

CPC classification number: C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.

公开(公告)号：EP1226146A2

公开(公告)日：2002-07-31

申请号：EP00976992.8

申请日：2000-11-06

Applicant: ABBOTT LABORATORIES

Inventor： ELMORE, Steven, W. ,  COOPER, Curt, S. ,  SCHULTZ, Colleen, C. ,  HUTCHINSON, Douglas, K. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  ANDERSON, David D. ,  XIE, Qinghua ,  DINGES, Jurgen ,  LYNCH, Linda, M.

IPC: C07D495/04 ,  A61K31/4709 ,  A61P31/04 ,  C07D519/00 ,  C07D471/04 ,  C07D409/04 ,  C07D409/14 ,  C07D513/04 ,  C07D417/14 ,  C07D413/14 ,  C07D417/04

CPC classification number: C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: Compounds having formula (I), or pharmaceutically acceptable salts or prodrugs thereof, wherein A1 is nitrogen or (II), wherein W is selected from the group consisting of (1) hydrogen and (2) optionally substituted alkyl; A2 is selected from the group consisting of (1) -S-, (2) -O-, and (3) -N(R7)-, wherein R7 is hydrogen or C¿1?-C6 alkyl; and R?5 and R6¿ together are a carbocyclic or a heterocyclic ring, are useful as antibacterial agents.