公开(公告)号：WO2004041818A1

公开(公告)日：2004-05-21

申请号：PCT/US2003/034707

申请日：2003-10-31

Applicant: ABBOTT LABORATORIES

Inventor： PRATT, John, K. ,  BETEBENNER, David, A. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  MCDANIEL, Keith, F. ,  MARING, Clarence, J. ,  STOLL, Vincent, S. ,  ZHANG, Rong

IPC: C07D471/04

CPC classification number: C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.

Abstract translation: 本发明提供具有式（I）的HCV聚合酶抑制化合物和包含治疗有效量的所述化合物的组合物。 本发明还提供抑制丙型肝炎病毒（HCV）聚合酶的方法，抑制HCV病毒复制的方法，以及治疗或预防HCV感染的方法。 还提供了用于制备所述化合物的方法和在所述方法中使用的合成中间体。

公开(公告)号：WO2009029123A1

公开(公告)日：2009-03-05

申请号：PCT/US2007/087514

申请日：2007-12-14

Applicant: ABBOTT LABORATORIES ,  REILLY, Edward, B. ,  LACY, Susan, E. ,  FUNG, Emma ,  BELK, Jonathan, P. ,  ROGUSKA, Michael ,  STOLL, Vincent, S. ,  JAKOB, Clarissa

Inventor： REILLY, Edward, B. ,  LACY, Susan, E. ,  FUNG, Emma ,  BELK, Jonathan, P. ,  ROGUSKA, Michael ,  STOLL, Vincent, S. ,  JAKOB, Clarissa

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/74 ,  C07K2317/92

Abstract: The present invention relates to antibodies and antigen-binding portions thereof that bind to and activate an erythropoietin receptor. The invention also relates to nucleic acid sequences encoding such antibodies and antigen-binding portions. The present invention further relates to methods of activating the endogenous activity of an erythropoietin receptor in a mammal using said antibodies and antigen-binding portions, methods of treatment, as well as pharmaceutical compositions comprising said antibodies and antigen-binding portions. The invention further provides compositions and crystals of an erythropoietin receptor in complex with an anti-erythropoietin receptor antibody. Specifically, the high-resolution structure provides binding sites defined by the structure coordinated determined herein.

Abstract translation: 本发明涉及结合并激活促红细胞生成素受体的抗体及其抗原结合部分。 本发明还涉及编码这种抗体和抗原结合部分的核酸序列。 本发明还涉及使用所述抗体和抗原结合部分，治疗方法以及包含所述抗体和抗原结合部分的药物组合物来激活哺乳动物中促红细胞生成素受体的内源性活性的方法。 本发明还提供与抗促红细胞生成素受体抗体复合的促红细胞生成素受体的组合物和晶体。 具体地，高分辨率结构提供由本文确定的结构所定义的结合位点。

公开(公告)号：WO2003051366A2

公开(公告)日：2003-06-26

申请号：PCT/US2002/039915

申请日：2002-12-12

Applicant: ABBOTT LABORATORIES

Inventor： LI, Qun ,  WOODS, Keith, W. ,  ZHU, Gui-Dong ,  FISCHER, John, P. ,  GONG, Jianchun ,  LI, Tongmei ,  GANDHI, Viraj ,  THOMAS, Sheela, A. ,  PACKARD, Garrick ,  SONG, Xiaohong ,  ABRAMS, Jason, N. ,  DIEBOLD, Robert ,  DINGES, Jurgen ,  HUTCHINS, Charles ,  STOLL, Vincent, S. ,  ROSENBERG, Saul, H. ,  GIRANDA, Vincent, L.

IPC: A61K31/4439

CPC classification number: C07D401/04 ,  C07D213/63 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C07D471/04 ,  C07D475/02

Abstract: Compounds having the formula (I), are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.

Abstract translation: 具有式（I）的化合物可用于抑制蛋白激酶。 还公开了抑制蛋白激酶的组合物和抑制患者蛋白激酶的方法。

公开(公告)号：WO2005019191A2

公开(公告)日：2005-03-03

申请号：PCT/US2004/027000

申请日：2004-08-19

Applicant: ABBOTT LABORATORIES ,  HUTCHINSON, Douglas, K. ,  BELLETTINI, John, R. ,  BETEBENNER, David, A. ,  BISHOP, Richard, D. ,  BORCHARDT, Thomas, B. ,  BOSSE, Todd, D. ,  CINK, Russell, D. ,  FLENTGE, Charles, A. ,  GATES, Bradley, D. ,  GREEN, Brian, E. ,  HINMAN, Mira, M. ,  HUANG, Peggy, P. ,  KLEIN, Larry, L. ,  KRUEGER, Allan, C. ,  LARSON, Daniel, P. ,  LEANNA, M., Robert ,  LIU, Dachun ,  MADIGAN, Darold, L. ,  MCDANIEL, Keith, F. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  ROSENBERG, Teresa, A. ,  STEWART, Kent, D. ,  STOLL, Vincent, S. ,  WAGNER, Rolf ,  YEUNG, Ming, C.

Inventor： HUTCHINSON, Douglas, K. ,  BELLETTINI, John, R. ,  BETEBENNER, David, A. ,  BISHOP, Richard, D. ,  BORCHARDT, Thomas, B. ,  BOSSE, Todd, D. ,  CINK, Russell, D. ,  FLENTGE, Charles, A. ,  GATES, Bradley, D. ,  GREEN, Brian, E. ,  HINMAN, Mira, M. ,  HUANG, Peggy, P. ,  KLEIN, Larry, L. ,  KRUEGER, Allan, C. ,  LARSON, Daniel, P. ,  LEANNA, M., Robert ,  LIU, Dachun ,  MADIGAN, Darold, L. ,  MCDANIEL, Keith, F. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  ROSENBERG, Teresa, A. ,  STEWART, Kent, D. ,  STOLL, Vincent, S. ,  WAGNER, Rolf ,  YEUNG, Ming, C.

IPC: C07D285/00

CPC classification number: C07D417/12 ,  C07D285/24 ,  C07D285/30 ,  C07D513/04

Abstract: Compounds having the formula (I) are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.

Abstract translation: 具有式（I）的化合物是丙型肝炎（HCV）聚合酶抑制剂。 还公开了用于抑制丙型肝炎（HCV）聚合酶的组合物和方法，用于制备化合物的方法和在该方法中使用的合成中间体。

公开(公告)号：WO2003051366A3

公开(公告)日：2003-06-26

申请号：PCT/US2002/039915

申请日：2002-12-12

Applicant: ABBOTT LABORATORIES

Inventor： LI, Qun ,  WOODS, Keith, W. ,  ZHU, Gui-Dong ,  FISCHER, John, P. ,  GONG, Jianchun ,  LI, Tongmei ,  GANDHI, Viraj ,  THOMAS, Sheela, A. ,  PACKARD, Garrick ,  SONG, Xiaohong ,  ABRAMS, Jason, N. ,  DIEBOLD, Robert ,  DINGES, Jurgen ,  HUTCHINS, Charles ,  STOLL, Vincent, S. ,  ROSENBERG, Saul, H. ,  GIRANDA, Vincent, L.

IPC: A61K31/4439

Abstract: Compounds having the formula (I), are useful for inhibiting protein kinases and for the treatment of cancer. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.

公开(公告)号：EP1560827B1

公开(公告)日：2010-12-29

申请号：EP03768559.1

申请日：2003-10-31

Applicant: ABBOTT LABORATORIES

Inventor： PRATT, John, K. ,  BETEBENNER, David, A. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  MCDANIEL, Keith, F. ,  MARING, Clarence, J. ,  STOLL, Vincent, S. ,  ZHANG, Rong

IPC: C07D471/04 ,  C07D513/04 ,  C07D519/00 ,  C07D495/04 ,  C07D417/04 ,  C07D513/14 ,  C07D417/14 ,  A61K31/554 ,  A61P31/00 ,  C07D215/22 ,  C07D401/04 ,  C07D213/69

CPC classification number: C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.

公开(公告)号：EP1087938A1

公开(公告)日：2001-04-04

申请号：EP99918495.5

申请日：1999-04-12

Applicant: ABBOTT LABORATORIES

Inventor： MARING, Clarence, J. ,  GU, Yu-Gui ,  CHEN, Yuanwei ,  DEGOEY, David, A. ,  GIRANDA, Vincent, L. ,  GRAMPOVNIK, David, J. ,  KATI, Warren, M. ,  KEMPF, Dale, J. ,  KENNEDY, April ,  LIN, Zhen ,  MADIGAN, Darold, L. ,  MUCHMORE, Steven, W. ,  SHAM, Hing, L. ,  STEWART, Kent, D. ,  STOLL, Vincent, S. ,  SUN, Minghua ,  WANG, Gary, T. ,  WANG, Sheldon ,  YEUNG, Ming, C.

IPC: C07C271/24 ,  C07C233/52 ,  C07C233/47 ,  C07C271/22 ,  C07D233/54 ,  C07D263/32 ,  A61K31/33 ,  A61K31/16 ,  C07C237/24 ,  C07D307/24 ,  C07D405/04

CPC classification number: C07D233/64 ,  C07C233/52 ,  C07C237/24 ,  C07C271/24 ,  C07C2601/08 ,  C07D307/24 ,  C07D317/32 ,  C07D493/08

Abstract: Disclosed are compounds of formula (I), (II) or (III), which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

Abstract translation: 公开了式（I），（II）或（III）的化合物，其可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶。 还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。

公开(公告)号：EP1560827A1

公开(公告)日：2005-08-10

申请号：EP03768559.1

申请日：2003-10-31

Applicant: Abbott Laboratories

Inventor： PRATT, John, K. ,  BETEBENNER, David, A. ,  DONNER, Pamela, L. ,  GREEN, Brian, E. ,  KEMPF, Dale, J. ,  MCDANIEL, Keith, F. ,  MARING, Clarence, J. ,  STOLL, Vincent, S. ,  ZHANG, Rong

IPC: C07D471/04 ,  C07D513/04 ,  C07D519/00 ,  C07D495/04 ,  C07D417/04 ,  C07D513/14 ,  C07D417/14 ,  A61K31/554 ,  A61P31/00 ,  C07D215/22 ,  C07D401/04 ,  C07D213/69

CPC classification number: C07D213/69 ,  C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.

公开(公告)号：EP1463505A2

公开(公告)日：2004-10-06

申请号：EP02790126.3

申请日：2002-12-12

Applicant: Abbott Laboratories

Inventor： LI, Qun ,  WOODS, Keith W. ,  ZHU, Gui-Dong ,  FISCHER, John P. ,  GONG, Jianchun ,  LI, Tongmei ,  GANDHI, Viraj ,  THOMAS, Sheela, A. ,  PACKARD, Garrick ,  SONG, Xiaohong ,  ABRAMS, Jason, N. ,  DIEBOLD, Robert ,  DINGES, Jurgen ,  HUTCHINS, Charles ,  STOLL, Vincent, S. ,  ROSENBERG, Saul, H. ,  GIRANDA, Vincent, L.

IPC: A61K31/4439 ,  A61K31/444 ,  C07D401/12 ,  C07D401/14 ,  C07D401/04 ,  C07D475/02 ,  C07D213/63

Abstract: Compounds having the formula (I), are useful for inhibiting protein kinases and for the treatment of cancer. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.

公开(公告)号：EP1379646A2

公开(公告)日：2004-01-14

申请号：EP01988771.0

申请日：2001-10-26

Applicant: ABBOTT LABORATORIES

Inventor： STEWART, Kent, D. ,  STEFFY, Kevin, R. ,  KEMPF, Dale, J. ,  HARRIS, Kevin, S. ,  HUTH, Jeffrey, R. ,  STOLL, Vincent, S. ,  HARLAN, John, E. ,  NG, Iok, C. ,  BETZ, Stephen, F.

IPC: C12N15/11 ,  C07K14/16 ,  G01N33/569

CPC classification number: C40B30/04 ,  C07K14/005 ,  C07K2319/00 ,  C12N2740/16122 ,  G01N33/56988 ,  G01N33/6842 ,  G01N33/6845 ,  G01N2500/04

Abstract: The subject invention encompasses novel proteins related to the human immunodeficiency virus (HIV-1) gp41 protein and to methods of use thereof. For example, the proteins may be utilized in the screening of anti-HIV compounds.