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1.发明申请
公开(公告)号：WO2006074330A2
公开(公告)日：2006-07-13
申请号：PCT/US2006/000402
申请日：2006-01-05
Applicant: ABBOTT LABORATORIES , ROHDE, Jeffrey, J. , SHUAI, Qi , LINK, James, T. , PATEL, Jyoti, R. , DINGES, Jurgen , SORENSEN, Bryan, K. , YONG, Hong
Inventor： ROHDE, Jeffrey, J. , SHUAI, Qi , LINK, James, T. , PATEL, Jyoti, R. , DINGES, Jurgen , SORENSEN, Bryan, K. , YONG, Hong
IPC: C07C233/63 , C07D213/56 , C07D231/12 , C07D261/08 , C07D333/24 , A61K31/165 , A61K31/4409 , A61K31/381 , A61K31/415 , A61K31/42 , A61P3/04 , A61P3/10
CPC classification number: C07D207/277 , C07C233/11 , C07C233/52 , C07C233/58 , C07C233/63 , C07C237/24 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D211/78 , C07D213/56 , C07D231/12 , C07D261/08 , C07D333/24
Abstract: The present invention relates to compounds that are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
Abstract translation: 本发明涉及作为11-β-羟基类固醇脱氢酶1型酶的抑制剂的化合物。 本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征和其他介导的疾病和病症的用途 由过度的糖皮质激素作用。
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2.发明申请
公开(公告)号：WO2003051366A3
公开(公告)日：2003-06-26
申请号：PCT/US2002/039915
申请日：2002-12-12
Applicant: ABBOTT LABORATORIES
Inventor： LI, Qun , WOODS, Keith, W. , ZHU, Gui-Dong , FISCHER, John, P. , GONG, Jianchun , LI, Tongmei , GANDHI, Viraj , THOMAS, Sheela, A. , PACKARD, Garrick , SONG, Xiaohong , ABRAMS, Jason, N. , DIEBOLD, Robert , DINGES, Jurgen , HUTCHINS, Charles , STOLL, Vincent, S. , ROSENBERG, Saul, H. , GIRANDA, Vincent, L.
IPC: A61K31/4439
Abstract: Compounds having the formula (I), are useful for inhibiting protein kinases and for the treatment of cancer. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.
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公开(公告)号：WO2009026422A3
公开(公告)日：2009-02-26
申请号：PCT/US2008/073830
申请日：2008-08-21
Applicant: ABBOTT LABORATORIES , BITNER, R., Scott , BROWMAN, Kaitlin, E , BRUNE, Michael, E , CHEN, Yixian , DINGES, Jurgen , DRESCHER, Karla , JACOBSON, Peer , JAE, Hwan-soo , KURUKULASURIYA, Ravi , LINK, James, T. , MADAR, David, J. , PATEL, Jyoti, R. , PLIUSHCHEV, Marina, A. , ROHDE, Jeffrey, J. , RUETER, Lynne, E. , SHUAI, Qi , SORENSEN, Bryan, K. , WANG, Jiahong , WICKE, Karsten, M. , WINN, Martin , WODKA, Dariusz , YEH, Vince , YONG, Hong
Inventor： BITNER, R., Scott , BROWMAN, Kaitlin, E , BRUNE, Michael, E , CHEN, Yixian , DINGES, Jurgen , DRESCHER, Karla , JACOBSON, Peer , JAE, Hwan-soo , KURUKULASURIYA, Ravi , LINK, James, T. , MADAR, David, J. , PATEL, Jyoti, R. , PLIUSHCHEV, Marina, A. , ROHDE, Jeffrey, J. , RUETER, Lynne, E. , SHUAI, Qi , SORENSEN, Bryan, K. , WANG, Jiahong , WICKE, Karsten, M. , WINN, Martin , WODKA, Dariusz , YEH, Vince , YONG, Hong
IPC: A61K31/495 , A61K31/445 , C07C233/23 , C07D471/02
Abstract: A method for treating a patient suffering from disorders and deficits of the central nervous system associated with diabetes, associated with aging and neurodegeneration, comprising attention deficit disorder in general, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, neurodegeneration, depression, and schizophrenia, comprising administering to a patient in need of such treatment an effective amount of a selective inhibitor of the 11-β-hydroxysteroid dehydrogenase Type 1 enzyme activity.
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4.发明申请
公开(公告)号：WO2006074244A2
公开(公告)日：2006-07-13
申请号：PCT/US2006/000210
申请日：2006-01-05
Applicant: ABBOTT LABORATORIES , PATEL, Jyoti, R. , SHUAI, Qi , LINK, James, T. , ROHDE, Jeffrey, J. , DINGES, Jurgen , SORENSEN, Bryan, K. , WINN, Martin , YONG, Hong , YEH, Vince, S.
Inventor： PATEL, Jyoti, R. , SHUAI, Qi , LINK, James, T. , ROHDE, Jeffrey, J. , DINGES, Jurgen , SORENSEN, Bryan, K. , WINN, Martin , YONG, Hong , YEH, Vince, S.
IPC: C07C235/14 , C07C317/16 , C07C323/41 , C07D257/04 , C07D233/54 , C07D261/08 , C07D213/64 , C07D207/48 , A61K31/4402 , A61P3/10
CPC classification number: C07C233/23 , C07C235/14 , C07C237/24 , C07C255/31 , C07C255/47 , C07C259/16 , C07C311/08 , C07C311/29 , C07C311/46 , C07C311/51 , C07C317/22 , C07C317/30 , C07C317/44 , C07C323/41 , C07C323/60 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C07D207/48 , C07D213/64 , C07D233/64 , C07D257/04 , C07D261/08
Abstract: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
Abstract translation: 本发明涉及作为11-β-羟基类固醇脱氢酶1型酶抑制剂的化合物。 本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征和其他介导的疾病和病症的用途 由过度的糖皮质激素作用。
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公开(公告)号：WO2003051366A2
公开(公告)日：2003-06-26
申请号：PCT/US2002/039915
申请日：2002-12-12
Applicant: ABBOTT LABORATORIES
Inventor： LI, Qun , WOODS, Keith, W. , ZHU, Gui-Dong , FISCHER, John, P. , GONG, Jianchun , LI, Tongmei , GANDHI, Viraj , THOMAS, Sheela, A. , PACKARD, Garrick , SONG, Xiaohong , ABRAMS, Jason, N. , DIEBOLD, Robert , DINGES, Jurgen , HUTCHINS, Charles , STOLL, Vincent, S. , ROSENBERG, Saul, H. , GIRANDA, Vincent, L.
IPC: A61K31/4439
CPC classification number: C07D401/04 , C07D213/63 , C07D401/12 , C07D401/14 , C07D403/14 , C07D409/14 , C07D471/04 , C07D475/02
Abstract: Compounds having the formula (I), are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.
Abstract translation: 具有式（I）的化合物可用于抑制蛋白激酶。 还公开了抑制蛋白激酶的组合物和抑制患者蛋白激酶的方法。
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Patent Agency Ranking
公开(公告)号：WO2002062761A1
公开(公告)日：2002-08-15
申请号：PCT/US2002/002949
申请日：2002-01-31
Applicant: ABBOTT LABORATORIES
Inventor： KORT, Michael, E. , CARROLL, William, A. , PEREZ MEDRANO, Arturo , DINGES, Jurgen , GREGG, Robert, J. , BASHA, Fatima, Z.
IPC: C07D213/74
CPC classification number: C07D213/74 , C07C233/78 , C07C2601/04 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/82 , C07D241/20 , C07D405/12 , C07D409/12
Abstract: Compounds of formula (I), may be useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Abstract translation: 式（I）化合物可用于治疗由钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。
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公开(公告)号：EP1318978A2
公开(公告)日：2003-06-18
申请号：EP01971244.7
申请日：2001-09-20
Applicant: Abbott Laboratories
Inventor： MCCLELLAN, William , OOST, Thorsten , BRUNCKO, Milan , WANG, Xilu , AUGERI, David, J. , BAUMEISTER, Steven, A. , DICKMAN, Daniel, A. , DING, Hong , DINGES, Jurgen , FESIK, Stephen, W. , HAJDUK, Philip, J. , KUNZER, Aaron, R. , NETTESHEIM, David, G. , PETROS, Andrew, M. , ROSENBERG, Saul, H. , SHEN, Wang , THOMAS, Sheela, A. , WENDT, Michael, D.
IPC: C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/58 , C07C323/60
CPC classification number: C07D207/404 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/58 , C07C323/60 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/28 , C07C2602/42 , C07C2602/44 , C07C2603/74 , C07D203/10 , C07D205/12 , C07D207/24 , C07D209/08 , C07D209/96 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/61 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/227 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D235/08 , C07D235/26 , C07D241/16 , C07D249/04 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D401/06 , C07D401/12 , C07D405/04 , C07D417/12 , C07D451/02
Abstract: N-Benzoyl arylsulfonamides having the formula (I) are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.
Abstract translation: 具有式（I）的N-苯甲酰基芳基磺酰胺是BCL-X1抑制剂，可用于促进凋亡。 还公开了BCL-X1抑制组合物和促进哺乳动物细胞凋亡的方法。
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8.发明公开ADAMANTYL DERIVATIVES AS INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME 有权ADAMANTYL-DERIVATE ALS INHIBITOREN DES 11-BETA-HYDOXOSTEROID-DEHYDROGENASE-1-ENZYMS
公开(公告)号：EP1846363A2
公开(公告)日：2007-10-24
申请号：EP06717418.5
申请日：2006-01-05
Applicant: ABBOTT LABORATORIES
Inventor： PATEL, Jyoti, R. , SHUAI, Qi , LINK, James, T. , ROHDE, Jeffrey, J. , DINGES, Jurgen , SORENSEN, Bryan, K. , WINN, Martin , YONG, Hong , YEH, Vince, S.
IPC: C07C235/14 , C07C317/16 , C07C323/41 , C07D257/04 , C07D233/54 , C07D261/08 , C07D213/64 , C07D207/48 , A61K31/4402 , A61P3/10
CPC classification number: C07C233/23 , C07C235/14 , C07C237/24 , C07C255/31 , C07C255/47 , C07C259/16 , C07C311/08 , C07C311/29 , C07C311/46 , C07C311/51 , C07C317/22 , C07C317/30 , C07C317/44 , C07C323/41 , C07C323/60 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C07D207/48 , C07D213/64 , C07D233/64 , C07D257/04 , C07D261/08
Abstract: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
Abstract translation: 本发明涉及作为11-β-羟基类固醇脱氢酶1型酶抑制剂的化合物。 本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征和其他介导的疾病和病症的用途 由过度的糖皮质激素作用。
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9.发明授权ADAMANTYL DERIVATIVES AS INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME 有权金刚衍生物作为11-β羟类固醇脱氢酶-1酶抑制剂
公开(公告)号：EP1846363B1
公开(公告)日：2012-04-25
申请号：EP06717418.5
申请日：2006-01-05
Applicant: Abbott Laboratories
Inventor： PATEL, Jyoti, R. , SHUAI, Qi , LINK, James, T. , ROHDE, Jeffrey, J. , DINGES, Jurgen , SORENSEN, Bryan, K. , WINN, Martin , YONG, Hong , YEH, Vince, S.
IPC: C07C235/14 , C07C317/16 , C07C323/41 , C07D257/04 , C07D233/54 , C07D261/08 , C07D213/64 , C07D207/48 , A61K31/4402 , A61P3/10
CPC classification number: C07C233/23 , C07C235/14 , C07C237/24 , C07C255/31 , C07C255/47 , C07C259/16 , C07C311/08 , C07C311/29 , C07C311/46 , C07C311/51 , C07C317/22 , C07C317/30 , C07C317/44 , C07C323/41 , C07C323/60 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C07D207/48 , C07D213/64 , C07D233/64 , C07D257/04 , C07D261/08
Abstract: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
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10.发明公开3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开3-（苯基烷氧基）-5-（苯基）一种癌的治疗作为激酶抑制剂的吡啶衍生物和相关化合物
公开(公告)号：EP1463505A2
公开(公告)日：2004-10-06
申请号：EP02790126.3
申请日：2002-12-12
Applicant: Abbott Laboratories
Inventor： LI, Qun , WOODS, Keith W. , ZHU, Gui-Dong , FISCHER, John P. , GONG, Jianchun , LI, Tongmei , GANDHI, Viraj , THOMAS, Sheela, A. , PACKARD, Garrick , SONG, Xiaohong , ABRAMS, Jason, N. , DIEBOLD, Robert , DINGES, Jurgen , HUTCHINS, Charles , STOLL, Vincent, S. , ROSENBERG, Saul, H. , GIRANDA, Vincent, L.
IPC: A61K31/4439 , A61K31/444 , C07D401/12 , C07D401/14 , C07D401/04 , C07D475/02 , C07D213/63
Abstract: Compounds having the formula (I), are useful for inhibiting protein kinases and for the treatment of cancer. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.
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