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    Locking rack and disposable sample cartridge
    3.
    发明公开
    Locking rack and disposable sample cartridge 失效
    锁定架和可拆卸的样品盒

    公开(公告)号：EP0287900A3

    公开(公告)日：1990-04-18

    申请号：EP88105532.1

    申请日：1988-04-07

    Applicant: ABBOTT LABORATORIES

    Inventor： Grandone, Cass J.

    IPC: G01N35/04 ,  B01L3/00

    CPC classification number: B01L3/5025

    Abstract: A plurality of disposable cartridges (20), each having a plurality of wells including at least one assay reaction well, are loaded in a plurality of open­ings arranged radially around a rack (30) of a carousel (10). Securing of the cartridges in a predetermined orienta­tion and position in said openings is ensured by means of alignment and securing means on the cartridges and corresponding means on the rack. A locking hub (40) with tangs is mounted on the rack and is rotated to cause the tangs to contact locator tabs on each cartridge to force locator nubs on each of the cartridges radially into corresponding notches on the rack, and to accura­tely wedge the cartridges against the outer periphery of the rack. The carousel indexes for positioning the cartridges under a variety of stations, one of which generally contains an optical reader such as a fluoro­meter.

    Automatic analyser
    4.
    发明公开
    Automatic analyser 失效
    自动分析

    公开(公告)号：EP0831329A2

    公开(公告)日：1998-03-25

    申请号：EP97114411.8

    申请日：1997-08-20

    Applicant: Abbott Laboratories

    Inventor： Arnquist, David C. ,  Barnes, Grady, III ,  Button, Richard D. ,  Dunn, Chadwick M. ,  East, Richard C., Jr. ,  Fritchie, Patrick P. ,  Galitz, Charles M. ,  Grandone, Cass J. ,  Gardner, Gregory E. ,  Gray, Robert C. ,  Holen, James T. ,  Luoma, Robert P., II ,  McCory, Jimmy D. ,  Mitchell, James E. ,  Murray, Adrian John ,  Murray, David W. ,  Ramsey, Jack F. ,  Sleszynski, Neal T. ,  Toth, Julius J.

    IPC: G01N35/04

    CPC classification number: B01L3/508 ,  B01L2300/0851 ,  G01N21/76 ,  G01N35/0092 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/00534 ,  G01N2035/00752 ,  G01N2035/0465 ,  G01N2035/0467

    Abstract: The structure embodiments disclosed relate to determination of an item of interest in a sample. One embodiment relates to a structure which comprises a process path (10). The process path (10) comprises a process lane (28) including a process step performance lane (62) where a process step is performed, and a process step avoidance lane (64) where the process step is avoided. A first prime mover (24) is operatively connected with the process path (10) for moving a container (15) holding the sample along the process path (10). A first pipetting system (198) is operatively associated with the process path (10) for introducing the sample to the container (15). A second pipetting system (132, 134) is operatively associated with the process path (10) for introducing a reagent to the container (15). A device (86) is operatively connected with the process path (10) and is selectively engagable with the container (15) for mixing the sample and the reagent in the container (15). A second prime mover (44) is operatively connected with the process path (10) for selectively positioning the container (15) in a selected one of the process step performance lane (62) and the process step avoidance lane (64). A reader (138) is operatively connected with the process path (10) for determining the item of interest in the sample based upon a reaction between the sample and the reagent.
    The method embodiments disclosed relate to determination of an item of interest in a sample. In one method, a process path (10) comprising a process lane (28) including a process step performance lane (62) where a process step is performed, and a process step avoidance lane (64) where the process step is avoided is provided. A container (15) holding the sample is moved along the process path (10). The sample is introduced to the container (15). A reagent is introduced to the container (15). The sample and the reagent are mixed in the container (15). The container (15) is selectively positioned in a selected one of the process step performance lane (62) and the process step avoidance lane (64). The item of interest in the sample is determined based upon a reaction between the sample and the reagent.

    Abstract translation: 所公开的结构实施例涉及样品中感兴趣物品的确定。 一个实施例涉及包括处理路径（10）的结构。 过程路径（10）包括包括执行处理步骤的处理步骤执行通道（62）和避免处理步骤的处理步骤回避通道（64）的处理通道（28）。 第一原动机（24）与处理路径（10）可操作地连接，用于沿着处理路径（10）移动保持样品的容器（15）。 第一移液系统（198）与用于将样品引入容器（15）的处理路径（10）可操作地相关联。 第二移液系统（132,134）与用于将试剂引入容器（15）的过程路径（10）可操作地相关联。 装置（86）与处理路径（10）可操作地连接，并且可选择地与容器（15）接合，用于将样品和试剂混合在容器（15）中。 第二原动机（44）与处理路径（10）可操作地连接，用于将容器（15）选择性地定位在所选择的一个工艺步骤性能车道（62）和工艺步骤回避车道（64）中。 读取器（138）与处理路径（10）可操作地连接，用于基于样品和试剂之间的反应来确定样品中的感兴趣物品。 所公开的方法实施例涉及确定样本中的感兴趣项目。 在一种方法中，提供包括处理通道（28）的处理路径（10），其包括执行处理步骤的处理步骤性能通道（62）和避免处理步骤的处理步骤回避通道（64） 。 保持样品的容器（15）沿着处理路径（10）移动。 将样品引入容器（15）。 将试剂引入容器（15）。 样品和试剂在容器（15）中混合。 容器（15）被选择性地定位在处理步骤执行车道（62）和处理步骤回避车道（64）中的所选择的一个中。 基于样品和试剂之间的反应确定样品中的感兴趣物质。

    Cartridge and methods for performing a solid-phase immunoassay
    7.
    发明公开
    Cartridge and methods for performing a solid-phase immunoassay 失效
    Vorrichtung und VerfahrenfürdieAusführungeines festphasen Immunoassays。

    公开(公告)号：EP0288793A2

    公开(公告)日：1988-11-02

    申请号：EP88105533.9

    申请日：1988-04-07

    Applicant: ABBOTT LABORATORIES

    Inventor： Brown, William E. III ,  Sebesta, Edward E. ,  Osikowicz, Eugene W. ,  Ramp, Sally K. ,  Grandone, Cass J.

    IPC: B01L3/00 ,  G01N33/50

    CPC classification number: B01L3/502 ,  G01N33/54366 ,  G01N35/025

    Abstract: A disposable cartridge suitable for performing automated solid-phase diagnostic assays which employs microparticles to complex an analyte and where the microparticle complex becomes retained and immobilized on a fibrous matrix such that the presence of analyte on the microparticles can be detected by optical means. A cartridge is disclosed which comprises a plurality of wells at least one of the wells comprises an entrance port and holding means for receiving and holding a quantity of sample and assay reagents, a fibrous matrix for retaining and immobilizing microparticle/analyte complexes for detection, the fibrous matrix positioned below the holding means, and having an average spatial separation of fibers greater than the average diameter of said microparticles, and an absorbent material positioned below the fibrous matrix to absorb any sample or assay reagents that flow through said fibrous matrix.

    Abstract translation: 一种适用于执行自动化固相诊断测定的一次性盒，其使用微粒来复合分析物，并且其中微粒复合物保留并固定在纤维基质上，使得可以通过光学方法检测微粒上分析物的存在。 公开了一种盒，其包括多个孔，至少一个孔包括入口和用于接收和保持一定量的样品和测定试剂的保持装置，用于保持和固定微粒/分析物复合物进行检测的纤维基质， 纤维基质定位在保持装置下方，并且具有大于所述微粒平均直径的纤维的平均空间分离，以及位于纤维基质下方的吸收材料，以吸收流过所述纤维基质的任何样品或测定试剂。

    Cartridge and methods for performing a solid-phase immunoassay
    10.
    发明公开
    Cartridge and methods for performing a solid-phase immunoassay 失效
    用于实施固相免疫法的方法和方法

    公开(公告)号：EP0288793A3

    公开(公告)日：1990-04-25

    申请号：EP88105533.9

    申请日：1988-04-07

    Applicant: ABBOTT LABORATORIES

    Inventor： Brown, William E. III ,  Sebesta, Edward E. ,  Osikowicz, Eugene W. ,  Ramp, Sally K. ,  Grandone, Cass J.

    IPC: B01L3/00 ,  G01N33/50

    CPC classification number: B01L3/502 ,  G01N33/54366 ,  G01N35/025

    Abstract: A disposable cartridge suitable for performing automated solid-phase diagnostic assays which employs microparticles to complex an analyte and where the microparticle complex becomes retained and immobilized on a fibrous matrix such that the presence of analyte on the microparticles can be detected by optical means. A cartridge is disclosed which comprises a plurality of wells at least one of the wells comprises an entrance port and holding means for receiving and holding a quantity of sample and assay reagents, a fibrous matrix for retaining and immobilizing microparticle/analyte complexes for detection, the fibrous matrix positioned below the holding means, and having an average spatial separation of fibers greater than the average diameter of said microparticles, and an absorbent material positioned below the fibrous matrix to absorb any sample or assay reagents that flow through said fibrous matrix.

    Abstract translation: 一种适用于执行自动化固相诊断测定的一次性盒，其使用微粒来复合分析物，并且其中微粒复合物保留并固定在纤维基质上，使得可以通过光学方法检测微粒上分析物的存在。 公开了一种盒，其包括多个孔，至少一个孔包括入口和用于接收和保持一定量的样品和测定试剂的保持装置，用于保持和固定微粒/分析物复合物进行检测的纤维基质， 纤维基质定位在保持装置下方，并且具有大于所述微粒平均直径的纤维的平均空间分离，以及位于纤维基质下方的吸收材料，以吸收流过所述纤维基质的任何样品或测定试剂。

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