公开(公告)号：WO2011047262A2

公开(公告)日：2011-04-21

申请号：PCT/US2010/052843

申请日：2010-10-15

Applicant: ABBOTT LABORATORIES ,  GHAYUR, Tariq ,  KAMATH, Rajesh V. ,  LIU, Junjian ,  HONORE, Marie P.

Inventor： GHAYUR, Tariq ,  KAMATH, Rajesh V. ,  LIU, Junjian ,  HONORE, Marie P.

IPC: C07K16/24 ,  C07K16/46 ,  C12N15/13 ,  C12N15/63 ,  C12N15/70 ,  C12N15/80 ,  C12N15/81 ,  C12N15/82 ,  C12N15/85 ,  C12N5/10 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12P21/08 ,  A61K39/395 ,  A61K51/10 ,  A61P19/02 ,  A61P37/00 ,  A61P3/10 ,  A61P9/10 ,  A61P9/00 ,  A61P13/12 ,  A61P25/16 ,  A61P7/06 ,  A61P11/00 ,  A61P17/06 ,  A61P19/08 ,  A61P15/00 ,  A61P5/00 ,  A61P35/00 ,  A61P35/02 ,  A61P31/12 ,  A61P1/04 ,  A61P31/18 ,  A61P31/00

CPC classification number: C07K16/00 ,  C07K16/22 ,  C07K16/241 ,  C07K16/245 ,  C07K16/2866 ,  C07K16/44 ,  C07K16/46 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：EP2101763B1

公开(公告)日：2012-07-18

申请号：EP07869109.4

申请日：2007-12-12

Applicant: ABBOTT LABORATORIES

Inventor： GOPALAKRISHNAN, Murali ,  HONORE, Marie P. ,  LEE, Chih-hung ,  MALYSZ, John ,  JI, Jianguo ,  LI, Tao ,  SCHRIMPF, Michael R. ,  SIPPY, Kevin B. ,  ANDERSON, David J.

IPC: A61K31/4245 ,  A61P25/28 ,  A61K45/06

CPC classification number: A61K31/4439 ,  A61K31/4245 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4709 ,  A61K45/06 ,  C07D413/04 ,  C07D413/14 ,  G01N33/944 ,  G01N2333/70571 ,  A61K2300/00

Abstract: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.

公开(公告)号：EP2488658A2

公开(公告)日：2012-08-22

申请号：EP10824164.7

申请日：2010-10-15

Applicant: Abbott Laboratories

Inventor： GHAYUR, Tariq ,  KAMATH, Rajesh V. ,  LIU, Junjian ,  HONORE, Marie P.

IPC: C12P21/08 ,  C12Q1/70

CPC classification number: C07K16/00 ,  C07K16/22 ,  C07K16/241 ,  C07K16/245 ,  C07K16/2866 ,  C07K16/44 ,  C07K16/46 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：EP2101763A2

公开(公告)日：2009-09-23

申请号：EP07869109.4

申请日：2007-12-12

Applicant: ABBOTT LABORATORIES

Inventor： GOPALAKRISHNAN, Murali ,  HONORE, Marie P. ,  LEE, Chih-hung ,  MALYSZ, John ,  JI, Jianguo ,  LI, Tao ,  SCHRIMPF, Michael R. ,  SIPPY, Kevin B. ,  ANDERSON, David J.

IPC: A61K31/4245 ,  A61P25/28 ,  A61K45/06

CPC classification number: A61K31/4439 ,  A61K31/4245 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4709 ,  A61K45/06 ,  C07D413/04 ,  C07D413/14 ,  G01N33/944 ,  G01N2333/70571 ,  A61K2300/00

Abstract: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.