公开(公告)号：WO2011008312A2

公开(公告)日：2011-01-20

申请号：PCT/US2010/027931

申请日：2010-03-19

Applicant: ABBOTT LABORATORIES ,  SCHRIMPF, Michael R. ,  LEE, Chih-Hung ,  LI, Tao ,  GFESSER, Gregory A. ,  MORTELL, Kathleen H. ,  FAGHIH, Ramin ,  NERSESIAN, Diana L. ,  SIPPY, Kevin B. ,  BUNNELLE, William H. ,  SCANIO, Marc ,  SHI, Lei ,  GOPALAKRISHNAN, Murali ,  DONNELLY-ROBERTS, Diana L. ,  HU, Min

Inventor： SCHRIMPF, Michael R. ,  LEE, Chih-Hung ,  LI, Tao ,  GFESSER, Gregory A. ,  MORTELL, Kathleen H. ,  FAGHIH, Ramin ,  NERSESIAN, Diana L. ,  SIPPY, Kevin B. ,  BUNNELLE, William H. ,  SCANIO, Marc ,  SHI, Lei ,  GOPALAKRISHNAN, Murali ,  DONNELLY-ROBERTS, Diana L. ,  HU, Min

IPC: C07D487/18

CPC classification number: C07D471/18 ,  C07D487/18

Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a , R 1 , R 2 , R 3 , R 4 , R 5 , U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Abstract translation: 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和吲哚啉衍生物， R 1，R 2，R 3，R 4，R 5，R 5，R 5，R 4， U，V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含此类化合物的组合物，以及使用此类化合物和组合物治疗疾病状况的方法以及鉴定此类化合物的方法。

公开(公告)号：WO2010036998A2

公开(公告)日：2010-04-01

申请号：PCT/US2009/058553

申请日：2009-09-28

Applicant: ABBOTT LABORATORIES ,  SCHRIMPF, Michael R. ,  LEE, Chih-Hung ,  LI, Tao ,  GFESSER, Gregory A. ,  MORTELL, Kathleen H. ,  FAGHIH, Ramin ,  NERSESIAN, Diana L. ,  SIPPY, Kevin B. ,  BUNNELLE, William H. ,  SCANIO, Marc ,  SHI, Lei ,  GOPALAKRISHNAN, Murali ,  DONNELLY-ROBERTS, Diana ,  HU, Min

Inventor： SCHRIMPF, Michael R. ,  LEE, Chih-Hung ,  LI, Tao ,  GFESSER, Gregory A. ,  MORTELL, Kathleen H. ,  FAGHIH, Ramin ,  NERSESIAN, Diana L. ,  SIPPY, Kevin B. ,  BUNNELLE, William H. ,  SCANIO, Marc ,  SHI, Lei ,  GOPALAKRISHNAN, Murali ,  DONNELLY-ROBERTS, Diana ,  HU, Min

IPC: A61K31/439 ,  C12Q1/02 ,  C07D471/08

CPC classification number: G01N33/5058 ,  C07D471/18 ,  C07D487/10 ,  C07D487/18 ,  G01N33/6896 ,  G01N2800/28 ,  G01N2800/30

Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R 1 , R 2 , R 3 , R 4 , R 5 , U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Abstract translation: 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

公开(公告)号：EP2101763A2

公开(公告)日：2009-09-23

申请号：EP07869109.4

申请日：2007-12-12

Applicant: ABBOTT LABORATORIES

Inventor： GOPALAKRISHNAN, Murali ,  HONORE, Marie P. ,  LEE, Chih-hung ,  MALYSZ, John ,  JI, Jianguo ,  LI, Tao ,  SCHRIMPF, Michael R. ,  SIPPY, Kevin B. ,  ANDERSON, David J.

IPC: A61K31/4245 ,  A61P25/28 ,  A61K45/06

CPC classification number: A61K31/4439 ,  A61K31/4245 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4709 ,  A61K45/06 ,  C07D413/04 ,  C07D413/14 ,  G01N33/944 ,  G01N2333/70571 ,  A61K2300/00

Abstract: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.

公开(公告)号：EP2101763B1

公开(公告)日：2012-07-18

申请号：EP07869109.4

申请日：2007-12-12

Applicant: ABBOTT LABORATORIES

Inventor： GOPALAKRISHNAN, Murali ,  HONORE, Marie P. ,  LEE, Chih-hung ,  MALYSZ, John ,  JI, Jianguo ,  LI, Tao ,  SCHRIMPF, Michael R. ,  SIPPY, Kevin B. ,  ANDERSON, David J.

IPC: A61K31/4245 ,  A61P25/28 ,  A61K45/06

CPC classification number: A61K31/4439 ,  A61K31/4245 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4709 ,  A61K45/06 ,  C07D413/04 ,  C07D413/14 ,  G01N33/944 ,  G01N2333/70571 ,  A61K2300/00

Abstract: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.

公开(公告)号：EP2344505A2

公开(公告)日：2011-07-20

申请号：EP09793046.5

申请日：2009-09-28

Applicant: Abbott Laboratories

Inventor： SCHRIMPF, Michael R. ,  LEE, Chih-Hung ,  LI, Tao ,  GFESSER, Gregory A. ,  MORTELL, Kathleen H. ,  FAGHIH, Ramin ,  NERSESIAN, Diana L. ,  SIPPY, Kevin B. ,  BUNNELLE, William H. ,  SCANIO, Marc ,  SHI, Lei ,  GOPALAKRISHNAN, Murali ,  DONNELLY-ROBERTS, Diana ,  HU, Min

IPC: C07D487/18 ,  A61K31/33 ,  A61P25/00

CPC classification number: G01N33/5058 ,  C07D471/18 ,  C07D487/10 ,  C07D487/18 ,  G01N33/6896 ,  G01N2800/28 ,  G01N2800/30

Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R
1 , R
2 , R
3 , R
4 , R
5 , U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.