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1.发明申请2-AMINOOXAZOLE DERIVATIVES AS TRPVL ANTAGONISTS USEFUL FOR TREATING PAIN 审中-公开用作治疗疼痛的TRPVL拮抗剂的2-氨基苯并噻唑衍生物
公开(公告)号：WO2009055749A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/081229
申请日：2008-10-25
Applicant: ABBOTT LABORATORIES , PERNER, Richard J. , KOENIG, John R. , DIDOMENICO, Stanley, Jr. , BAYBURT, Erol, K. , DAANEN, Jerome, F. , GOMTSYAN, Arthur, R. , KORT, Michael E. , KYM, Philip R. , VASUDEVAN, Anil , SCHMIDT, Robert, G. , VOIGHT, Eric
Inventor： PERNER, Richard J. , KOENIG, John R. , DIDOMENICO, Stanley, Jr. , BAYBURT, Erol, K. , DAANEN, Jerome, F. , GOMTSYAN, Arthur, R. , KORT, Michael E. , KYM, Philip R. , VASUDEVAN, Anil , SCHMIDT, Robert, G. , VOIGHT, Eric
IPC: C07D263/48 , C07D413/04 , C07D413/12 , A61K31/421 , A61P29/00
CPC classification number: C07D413/12 , C07D263/48 , C07D413/04
Abstract: Compounds of formula (I) wherein R 1 , R 2 , R 4 , and W are defined in the description are TRPV1 antagonists with CNS penetration. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Abstract translation: 在描述中定义R1，R2，R4和W的式（I）化合物是具有CNS穿透的TRPV1拮抗剂。 还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。
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2.发明申请ANTAGONISTS OF THE VANILLOID RECEPTOR SUBTYPE 1 (VR1) AND USES THEREOF 审中-公开VANILLOID受体亚型1（VR1）的拮抗剂及其用途
公开(公告)号：WO2007121299A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/066515
申请日：2007-04-12
Applicant: ABBOTT LABORATORIES , BROWN, Brian S. , KOENIG, John R. , GOMTSYAN, Arthur R. , LEE, Chih-Hung
Inventor： BROWN, Brian S. , KOENIG, John R. , GOMTSYAN, Arthur R. , LEE, Chih-Hung
IPC: A61K31/519 , A61K31/4747 , C07D498/10
CPC classification number: C07D491/107 , C07D405/12 , C07D493/10
Abstract: The present invention is directed to compounds of formula (I), wherein variables X 1 , X 2 , Y, R 1a , R1 b , R 2a , R 2b , A 1 , A 2 , A 3 , and A 4 are as defined in the description, and methods of use to treat pain, neuropathic pain, allodynia, pain associated with inflammation or an inflammatory disease, inflammatory hyperalgesia, bladder overactivity, and urinary incontinence.
Abstract translation: 本发明涉及式（I）化合物，其中X 1，X 2，Y，R 1a，R 1， R b，R 2b，R 2b，A 1，A 2，A SUB， > 3 和A 4 <4>如描述中所定义，以及用于治疗疼痛，神经性疼痛，异常性疼痛，与炎症或炎性疾病相关的疼痛，炎性痛觉过敏，膀胱 过度活动和尿失禁。
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Patent Agency Ranking3.发明授权2-AMINOOXAZOLE DERIVATIVES AS TRPVL ANTAGONISTS USEFUL FOR TREATING PAIN 有权2- AMINOOXAZOLDERIVATE AS疼痛SUITABLE的TRPV1拮抗剂的治疗
公开(公告)号：EP2220059B1
公开(公告)日：2011-08-03
申请号：EP08841479.2
申请日：2008-10-25
Applicant: Abbott Laboratories
Inventor： PERNER, Richard J. , KOENIG, John R. , DIDOMENICO, Stanley, Jr. , BAYBURT, Erol, K. , DAANEN, Jerome, F. , GOMTSYAN, Arthur, R. , KORT, Michael E. , KYM, Philip R. , VASUDEVAN, Anil , SCHMIDT, Robert, G. , VOIGHT, Eric
IPC: C07D263/48 , C07D413/04 , C07D413/12 , A61K31/421 , A61P29/00
CPC classification number: C07D413/12 , C07D263/48 , C07D413/04
Abstract: Compounds of formula (I) wherein R1, R2, R4, and W are defined in the description are TRPV1 antagonists with CNS penetration. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
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4.发明公开2-AMINOOXAZOLE DERIVATIVES AS TRPVL ANTAGONISTS USEFUL FOR TREATING PAIN 有权2-AMINOOXAZOLE DERIVATIVES TRPVL ANTAGONISTS用于治疗疼痛
公开(公告)号：EP2220059A1
公开(公告)日：2010-08-25
申请号：EP08841479.2
申请日：2008-10-25
Applicant: Abbott Laboratories
Inventor： PERNER, Richard J. , KOENIG, John R. , DIDOMENICO, Stanley, Jr. , BAYBURT, Erol, K. , DAANEN, Jerome, F. , GOMTSYAN, Arthur, R. , KORT, Michael E. , KYM, Philip R. , VASUDEVAN, Anil , SCHMIDT, Robert, G. , VOIGHT, Eric
IPC: C07D263/48 , C07D413/04 , C07D413/12 , A61K31/421 , A61P29/00
CPC classification number: C07D413/12 , C07D263/48 , C07D413/04
Abstract: Compounds of formula (I) wherein R1, R2, R4, and W are defined in the description are TRPV1 antagonists with CNS penetration. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Abstract translation: 其中R 1，R 2，R 4和W在说明书中定义的式（I）化合物是具有CNS穿透的TRPV1拮抗剂。 还公开了包含此类化合物的组合物以及使用此类化合物和组合物治疗疾病和病症的方法。
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5.发明授权FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR 有权CONDENSED AZABICYCLISCHEVERBINDUNGEN作为香草素受体1的抑制剂（VR1）
公开(公告)号：EP1478363B1
公开(公告)日：2009-01-14
申请号：EP03716014.0
申请日：2003-02-11
Applicant: ABBOTT LABORATORIES
Inventor： LEE, Chih-Hung , BAYBURT, Erol, K. , DIDOMENICO, Stanley Jr. , DRIZIN, Irene , GOMTSYAN, Arthur, R. , KOENIG, John R. , PERNER, Richard, J. , SCHMIDT, Robert G. , TURNER, Sean C. , WHITE, Tammie, K. , ZHENG, Guo, Zhu
IPC: A61K31/502 , C07D217/02 , C07D237/28 , C07D217/22 , C07D209/08 , C07D231/56 , A61K31/472 , A61K31/416 , A61K31/404
CPC classification number: C07D249/08 , A61K31/404 , A61K31/416 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/12 , C07D231/56 , C07D233/56 , C07D237/28 , C07D401/12 , C07D405/12
Abstract: Compounds of formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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6.发明公开
公开(公告)号：EP2012778A2
公开(公告)日：2009-01-14
申请号：EP07760554.1
申请日：2007-04-12
Applicant: Abbott Laboratories
Inventor： BROWN, Brian S. , KOENIG, John R. , GOMTSYAN, Arthur R. , LEE, Chih-Hung
IPC: A61K31/416 , A61K31/352 , C07D231/56 , C07D493/00
CPC classification number: C07D491/107 , C07D405/12 , C07D493/10
Abstract: The present invention is directed to compounds of formula (I), wherein variables X1, X2, Y, R1a, R1b, R2a, R2b, A1, A2, A3, and A4 are as defined in the description, and methods of use to treat pain, neuropathic pain, allodynia, pain associated with inflammation or an inflammatory disease, inflammatory hyperalgesia, bladder overactivity, and urinary incontinence.
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7.发明公开FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR 有权CONDENSED AZABICYCLISCHEVERBINDUNGEN作为香草素受体1的抑制剂（VR1）
公开(公告)号：EP1478363A1
公开(公告)日：2004-11-24
申请号：EP03716014.0
申请日：2003-02-11
Applicant: Abbott Laboratories
Inventor： LEE, Chih-Hung , BAYBURT, Erol, K. , DIDOMENICO, Stanley Jr. , DRIZIN, Irene , GOMTSYAN, Arthur, R. , KOENIG, John R. , PERNER, Richard, J. , SCHMIDT, Robert G. , TURNER, Sean C. , WHITE, Tammie, K. , ZHENG, Guo, Zhu
IPC: A61K31/502 , C07D217/02 , C07D237/28 , C07D217/22 , C07D209/08 , C07D231/56 , A61K31/472 , A61K31/416 , A61K31/404
CPC classification number: C07D249/08 , A61K31/404 , A61K31/416 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/12 , C07D231/56 , C07D233/56 , C07D237/28 , C07D401/12 , C07D405/12
Abstract: Compounds of formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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