公开(公告)号：WO2011146089A1

公开(公告)日：2011-11-24

申请号：PCT/US2010/057454

申请日：2010-11-19

Applicant: ABBOTT LABORATORIES ,  AKRITOPOULOU-ZANZE, Irini ,  BRAJE, Wilfried ,  DJURIC, Stevan W. ,  WILSON, Noel S. ,  TURNER, Sean C. ,  KRUGER, Albert W. ,  RELO, Ana-Lucia ,  SHEKHAR, Shashank ,  WELCH, Dennie S. ,  ZHAO, Hongyu ,  GANDARILLA, Jorge ,  GASIECKI, Alan F. ,  LI, Huanqiu ,  THOMPSON, Christina M. ,  ZHANG, Min ,  ABBOTT GMBH & CO. KG

Inventor： AKRITOPOULOU-ZANZE, Irini ,  BRAJE, Wilfried ,  DJURIC, Stevan W. ,  WILSON, Noel S. ,  TURNER, Sean C. ,  KRUGER, Albert W. ,  RELO, Ana-Lucia ,  SHEKHAR, Shashank ,  WELCH, Dennie S. ,  ZHAO, Hongyu ,  GANDARILLA, Jorge ,  GASIECKI, Alan F. ,  LI, Huanqiu ,  THOMPSON, Christina M. ,  ZHANG, Min

IPC: A01N43/00 ,  A01N43/46 ,  A61K31/55

CPC classification number: C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[ c ]pyrrole, and octahydrocyclohepta[ c ]pyrrole derivatives of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , A, Y 1 , Y 2 , and Y 3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Abstract translation: 本申请涉及式（I）的芳基 - 和杂芳基 - 稠合十氢吡咯并氮平，二氢八氢化吡咯并噻吩，十氢环庚三烯并[c]吡咯和八氢环庚三烯并[c]吡咯衍生物，其中R1，R2，R3，R4，R5，A，Y1 ，Y2和Y3如说明书中所定义。 本申请还涉及包含这些化合物的组合物，制备这些化合物的方法，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

公开(公告)号：EP1478363B1

公开(公告)日：2009-01-14

申请号：EP03716014.0

申请日：2003-02-11

Applicant: ABBOTT LABORATORIES

Inventor： LEE, Chih-Hung ,  BAYBURT, Erol, K. ,  DIDOMENICO, Stanley Jr. ,  DRIZIN, Irene ,  GOMTSYAN, Arthur, R. ,  KOENIG, John R. ,  PERNER, Richard, J. ,  SCHMIDT, Robert G. ,  TURNER, Sean C. ,  WHITE, Tammie, K. ,  ZHENG, Guo, Zhu

IPC: A61K31/502 ,  C07D217/02 ,  C07D237/28 ,  C07D217/22 ,  C07D209/08 ,  C07D231/56 ,  A61K31/472 ,  A61K31/416 ,  A61K31/404

CPC classification number: C07D249/08 ,  A61K31/404 ,  A61K31/416 ,  A61K31/47 ,  A61K31/472 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  C07D209/08 ,  C07D217/02 ,  C07D217/22 ,  C07D217/24 ,  C07D217/26 ,  C07D231/12 ,  C07D231/56 ,  C07D233/56 ,  C07D237/28 ,  C07D401/12 ,  C07D405/12

Abstract: Compounds of formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.

公开(公告)号：EP1478363A1

公开(公告)日：2004-11-24

申请号：EP03716014.0

申请日：2003-02-11

Applicant: Abbott Laboratories

Inventor： LEE, Chih-Hung ,  BAYBURT, Erol, K. ,  DIDOMENICO, Stanley Jr. ,  DRIZIN, Irene ,  GOMTSYAN, Arthur, R. ,  KOENIG, John R. ,  PERNER, Richard, J. ,  SCHMIDT, Robert G. ,  TURNER, Sean C. ,  WHITE, Tammie, K. ,  ZHENG, Guo, Zhu

IPC: A61K31/502 ,  C07D217/02 ,  C07D237/28 ,  C07D217/22 ,  C07D209/08 ,  C07D231/56 ,  A61K31/472 ,  A61K31/416 ,  A61K31/404

CPC classification number: C07D249/08 ,  A61K31/404 ,  A61K31/416 ,  A61K31/47 ,  A61K31/472 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  C07D209/08 ,  C07D217/02 ,  C07D217/22 ,  C07D217/24 ,  C07D217/26 ,  C07D231/12 ,  C07D231/56 ,  C07D233/56 ,  C07D237/28 ,  C07D401/12 ,  C07D405/12

Abstract: Compounds of formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.

公开(公告)号：EP1278746A2

公开(公告)日：2003-01-29

申请号：EP01934990.1

申请日：2001-05-02

Applicant: Abbott Laboratories

Inventor： CARROLL, William A. ,  AGRIOS, Konstantinos A. ,  BASHA, Fatima Z. ,  CHEN, Yiyuan ,  KORT, Michael E. ,  KYM, Philip R. ,  TANG, Rui ,  TURNER, Sean C. ,  YI, Lin

IPC: C07D471/14 ,  A61K31/4353 ,  A61P15/00 ,  A61P21/00 ,  C07D471/04 ,  C07D491/048 ,  C07D495/14 ,  C07D491/056

CPC classification number: C07D471/04 ,  C07C45/00 ,  C07C45/298 ,  C07C45/30 ,  C07C45/63 ,  C07C205/44 ,  C07D471/14 ,  C07D491/04 ,  C07D491/14 ,  C07D495/14 ,  C07C47/55

Abstract: Compounds having the formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.