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1.发明申请PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 审中-公开作为DIPPTIDYL PEPTIDASE-IV（DPP-IV）的抑制剂的药物组合物
公开(公告)号：WO2004026822A2
公开(公告)日：2004-04-01
申请号：PCT/US2003/029018
申请日：2003-09-15
Applicant: ABBOTT LABORATORIES
Inventor： MADAR, David , PEI, Zhonghua , PIREH, Daisy , DJURIC, Stevan, W. , WIEDEMAN, Paul, E. , YONG, Hong , FEENSTRA, Melissa, J. , KOPECKA, Hana , LI, Xiaofeng , LONGENECKER, Kenton , SHAM, Hing, L. , STEWART, Kent, D. , SZCZEPANKIEWICZ, Bruce, G.
IPC: C07D207/00
CPC classification number: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
Abstract translation: 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，X综合征，高胰岛素血症，肥胖症，动脉粥样硬化和各种免疫调节疾病 。
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Patent Agency Ranking2.发明授权PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 有权药物组合物及其用途作为二肽基肽酶IV抑制剂（DPP-IV）
公开(公告)号：EP1560811B1
公开(公告)日：2007-08-01
申请号：EP03774478.6
申请日：2003-09-15
Applicant: ABBOTT LABORATORIES
Inventor： MADAR, David , PEI, Zhonghua , PIREH, Daisy , DJURIC, Stevan, W. , WIEDEMAN, Paul, E. , YONG, Hong , MICHMERHUIZEN, Melissa, J. , KOPECKA, Hana , LI, Xiaofeng , LONGENECKER, Kenton , SHAM, Hing, L. , STEWART, Kent, D. , SZCZEPANKIEWICZ, Bruce, G.
IPC: C07D207/00
CPC classification number: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R1,R2 and R3 have the definitions given in the description.
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3.发明公开PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 有权药物组合物及其用途作为二肽基肽酶IV抑制剂（DPP-IV）
公开(公告)号：EP1560811A2
公开(公告)日：2005-08-10
申请号：EP03774478.6
申请日：2003-09-15
Applicant: Abbott Laboratories
Inventor： MADAR, David , PEI, Zhonghua , PIREH, Daisy , DJURIC, Stevan, W. , WIEDEMAN, Paul, E. , YONG, Hong , FEENSTRA, Melissa, J. , KOPECKA, Hana , LI, Xiaofeng , LONGENECKER, Kenton , SHAM, Hing, L. , STEWART, Kent, D. , SZCZEPANKIEWICZ, Bruce, G.
IPC: C07D207/00
CPC classification number: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R1,R2 and R3 have the definitions given in the description.
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公开(公告)号：EP2134685A1
公开(公告)日：2009-12-23
申请号：EP08745934.3
申请日：2008-04-16
Applicant: Abbott Laboratories
Inventor： BRUNCKO, Milan , SONG, Xiaohong , DING, Hong , TAO, Zhi-fu , KUNZER, Aaron R , ELMORE, Steven, W. , PARK, Cheol-Min , MADAR, David , WANG, Xilu , SOUERS, Andrew, J.
IPC: C07D209/42 , C07D403/04 , A61K31/404 , A61K31/405 , A61P35/00
CPC classification number: C07D209/42 , C07D403/04
Abstract: Compounds of formula (I) which inhibit the activity of anti-apoptotic Mcl-1 protein, compositins containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
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公开(公告)号：EP2134684A2
公开(公告)日：2009-12-23
申请号：EP08745970.7
申请日：2008-04-16
Applicant: Abbott Laboratories
Inventor： ELMORE, Steven, W. , SOUERS, Andrew, J. , BRUNCKO, Milan , SONG, Xiaohong , WANG, Xilu , HASVOLD, Lisa, A. , WANG, Le , KUNZER, Aaron, R. , PARK, Cheol-min , WENDT, Michael, D. , TAO, Zhi-fu , MADAR, David
IPC: C07D209/34 , C07D401/12 , C07D413/06 , C07D417/04 , A61P35/00 , A61K31/404
CPC classification number: C07D209/42 , A61K31/5377 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D491/113
Abstract: Compounds of formula (I) which inhibit the activity of anti-apoptotic McI-I protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated McI-I protein are disclosed.
Abstract translation: 公开了抑制抗细胞凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物，以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。
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6.发明授权PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 有权药物组合物及其用途作为二肽基肽酶IV抑制剂（DPP-IV）
公开(公告)号：EP1560811B9
公开(公告)日：2008-03-05
申请号：EP03774478.6
申请日：2003-09-15
Applicant: ABBOTT LABORATORIES
Inventor： MADAR, David , PEI, Zhonghua , PIREH, Daisy , DJURIC, Stevan, W. , WIEDEMAN, Paul, E. , YONG, Hong , MICHMERHUIZEN, Melissa, J. , KOPECKA, Hana , LI, Xiaofeng , LONGENECKER, Kenton , SHAM, Hing, L. , STEWART, Kent, D. , SZCZEPANKIEWICZ, Bruce, G.
IPC: C07D207/00
CPC classification number: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R1,R2 and R3 have the definitions given in the description.
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