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公开(公告)号：WO1991019733A1
公开(公告)日：1991-12-26
申请号：PCT/US1991004458
申请日：1991-06-20
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , SHIOSAKI, Kazumi , NADZAN, Alex, M. , KOPECKA, Hana , SHUE, Youe-Kona , HOLLADAY, Mark, W. , LIN, Chun, W. , NELLANS, Hugh, N.
IPC: C07K05/00
CPC classification number: C07K5/0215 , A61K38/00 , C07K5/0207 , C07K5/0815 , C07K5/0821 , C07K5/1016 , C07K5/1024 , C07K14/595
Abstract: Selective and potent Type-A CCK receptor agonists of formula (I): X-Y-Z-Q, or a pharmaceutically acceptable salt thereof, wherein, X is selected from (a) and (b); Y is selected from (c) and (d); Z is (e); and Q is (f), or pharmaceutically-acceptable salts thereof, useful in the treatment of gastrointestinal disorders (including gallbladder disorders), central nervous system disorders, insuline-related disorders and pain, as well as in appetite regulation.
Abstract translation: 选择性和有效的式（I）的CCK受体激动剂：X-Y-Z-Q或其药学上可接受的盐，其中X选自（a）和（b）; Y选自（c）和（d）; Z是（e）; 和Q是（f）或其药学上可接受的盐，其可用于治疗胃肠道疾病（包括胆囊疾病），中枢神经系统疾病，胰岛素相关疾病和疼痛以及食欲调节。
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Patent Agency Ranking2.发明申请PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 审中-公开作为DIPPTIDYL PEPTIDASE-IV（DPP-IV）的抑制剂的药物组合物
公开(公告)号：WO2004026822A2
公开(公告)日：2004-04-01
申请号：PCT/US2003/029018
申请日：2003-09-15
Applicant: ABBOTT LABORATORIES
Inventor： MADAR, David , PEI, Zhonghua , PIREH, Daisy , DJURIC, Stevan, W. , WIEDEMAN, Paul, E. , YONG, Hong , FEENSTRA, Melissa, J. , KOPECKA, Hana , LI, Xiaofeng , LONGENECKER, Kenton , SHAM, Hing, L. , STEWART, Kent, D. , SZCZEPANKIEWICZ, Bruce, G.
IPC: C07D207/00
CPC classification number: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
Abstract translation: 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，X综合征，高胰岛素血症，肥胖症，动脉粥样硬化和各种免疫调节疾病 。
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3.发明授权PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 有权药物组合物及其用途作为二肽基肽酶IV抑制剂（DPP-IV）
公开(公告)号：EP1560811B9
公开(公告)日：2008-03-05
申请号：EP03774478.6
申请日：2003-09-15
Applicant: ABBOTT LABORATORIES
Inventor： MADAR, David , PEI, Zhonghua , PIREH, Daisy , DJURIC, Stevan, W. , WIEDEMAN, Paul, E. , YONG, Hong , MICHMERHUIZEN, Melissa, J. , KOPECKA, Hana , LI, Xiaofeng , LONGENECKER, Kenton , SHAM, Hing, L. , STEWART, Kent, D. , SZCZEPANKIEWICZ, Bruce, G.
IPC: C07D207/00
CPC classification number: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R1,R2 and R3 have the definitions given in the description.
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4.发明授权PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 有权药物组合物及其用途作为二肽基肽酶IV抑制剂（DPP-IV）
公开(公告)号：EP1560811B1
公开(公告)日：2007-08-01
申请号：EP03774478.6
申请日：2003-09-15
Applicant: ABBOTT LABORATORIES
Inventor： MADAR, David , PEI, Zhonghua , PIREH, Daisy , DJURIC, Stevan, W. , WIEDEMAN, Paul, E. , YONG, Hong , MICHMERHUIZEN, Melissa, J. , KOPECKA, Hana , LI, Xiaofeng , LONGENECKER, Kenton , SHAM, Hing, L. , STEWART, Kent, D. , SZCZEPANKIEWICZ, Bruce, G.
IPC: C07D207/00
CPC classification number: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R1,R2 and R3 have the definitions given in the description.
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5.发明公开PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 有权药物组合物及其用途作为二肽基肽酶IV抑制剂（DPP-IV）
公开(公告)号：EP1560811A2
公开(公告)日：2005-08-10
申请号：EP03774478.6
申请日：2003-09-15
Applicant: Abbott Laboratories
Inventor： MADAR, David , PEI, Zhonghua , PIREH, Daisy , DJURIC, Stevan, W. , WIEDEMAN, Paul, E. , YONG, Hong , FEENSTRA, Melissa, J. , KOPECKA, Hana , LI, Xiaofeng , LONGENECKER, Kenton , SHAM, Hing, L. , STEWART, Kent, D. , SZCZEPANKIEWICZ, Bruce, G.
IPC: C07D207/00
CPC classification number: C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R1,R2 and R3 have the definitions given in the description.
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公开(公告)号：EP0449884A1
公开(公告)日：1991-10-09
申请号：EP90900650.0
申请日：1989-12-18
Applicant: ABBOTT LABORATORIES
Inventor： SHIOSAKI, Kazumi , NADZAN, Alex, M. , KOPECKA, Hana , SHUE, Youe-Kong
CPC classification number: C07K5/0821 , A61K38/00 , C07K5/0207 , C07K5/0215 , C07K5/0815 , C07K5/1016 , C07K5/1024 , C07K14/595
Abstract: Les analogues de tétrapeptides décrits possèdent une activité similaire à la cholécystokinine (CCK).
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