公开(公告)号：WO2005110124A1

公开(公告)日：2005-11-24

申请号：PCT/US2004/011550

申请日：2004-04-15

Applicant: ABBOTT LABORATORIES

Inventor： COMER, Gail, M. ,  CHENG, Lucia ,  MUSTAD, Vikkie ,  HUANG, Yung-Sheng ,  MCEWEN, John ,  DEMICHELE, Stephen, J. ,  BISTRIAN, Bruce, R.

IPC: A23L1/305

CPC classification number: A61K31/195 ,  A23L33/115 ,  A23L33/175 ,  A23L33/22 ,  A23L33/40 ,  A23V2002/00 ,  A61K2300/00 ,  A23V2250/1882 ,  A23V2250/70 ,  A23V2250/156 ,  A23V2250/06 ,  A23V2250/5046 ,  A23V2250/54252 ,  A23V2250/264 ,  A23V2250/72

Abstract: This invention relates to compositions and methods for nutritional management of hepatic (liver) failure. In particular the invention is directed to a nutritionally complete formulation suitable for use as a supplement or total enteral feeding. The composition is specifically tailored to meet the requirements of hepatic patients in need of nutritional support. The composition comprises an organoleptically acceptable protein system designed to meet the altered metabolic needs of patients suffering from hepatic failure. The invention also relates to administering a nutritional composition comprising effective amounts of the branched-chain amino acids, valine, leucine, isoleucine, or mixtures thereof, and with or without a reduced amount of tyrosine, phenylalanine and tryptophan.

Abstract translation: 本发明涉及肝（肝）衰竭的营养管理的组合物和方法。 特别地，本发明涉及适合用作补充剂或总肠内喂养的营养完全的制剂。 该组合物专门为满足需要营养支持的肝脏患者的要求而定制。 该组合物包含设计用于满足患有肝衰竭的患者改变的代谢需要的感觉可接受的蛋白质系统。 本发明还涉及施用包含有效量的支链氨基酸，缬氨酸，亮氨酸，异亮氨酸或其混合物，以及有或没有减少量的酪氨酸，苯丙氨酸和色氨酸的营养组合物。

公开(公告)号：WO2015095570A3

公开(公告)日：2015-06-25

申请号：PCT/US2014/071236

申请日：2014-12-18

Applicant: ABBOTT LABORATORIES

Inventor： JOHNS, Paul ,  NEAL, Cynthia ,  MCEWEN, John ,  MCKENNA, Ronald

IPC: A23L1/30 ,  A23L1/302 ,  A23L1/304 ,  A23L1/305 ,  A23L1/29 ,  A61K31/202 ,  A61P3/04

Abstract: Liquid nutritional compositions include specific combinations of protein, carbohydrate, and fat for the nutritional support of individuals with particular needs, such as individual suffering from obesity. The compositions comprise a source of at least one omega-6 fatty acid and a source of at least one omega-3 fatty acid with a ratio of omega-6 to omega-3 of 1:5 to 1:1. In a preferred form the compositions comprise at least one hydrolysed dairy protein selected from hydrolysed whey protein and hydrolysed casein protein or mixtures thereof. Methods of administering such nutritional compositions are also provided. Further liquid nutritional compositions comprise protein in an amount of 1-12% by weight of the liquid nutritional composition, vitamin C and copper, wherein the protein comprises a mixture of whey protein and casein with a majority of the whey protein having a degree of hydrolysis greater than 20%. Methods for improving vitamin C stability in these liquid nutritional compositions are also provided.

公开(公告)号：EP3082465A2

公开(公告)日：2016-10-26

申请号：EP14824723.2

申请日：2014-12-18

Applicant: Abbott Laboratories

Inventor： JOHNS, Paul ,  NEAL, Cynthia ,  MCEWEN, John ,  MCKENNA, Ronald

IPC: A23L33/10 ,  A23L33/15 ,  A23L33/16 ,  A23L33/00 ,  A61K31/202 ,  A61P3/04

CPC classification number: A61K38/018 ,  A23L33/115 ,  A23L33/12 ,  A23L33/125 ,  A23L33/15 ,  A23L33/16 ,  A23L33/17 ,  A23L33/18 ,  A23L33/19 ,  A23L33/21 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A61K9/0095 ,  A61K31/202 ,  A61K31/375 ,  A61K33/34 ,  A61K45/06 ,  A61K2300/00 ,  A23V2250/0612 ,  A23V2250/0644 ,  A23V2250/5036 ,  A23V2250/702 ,  A23V2250/71 ,  A23V2250/712 ,  A23V2250/714

Abstract: Nutritional compositions include unique combinations of protein, carbohydrate, and fat for the nutritional support of individuals with particular needs, such as individual suffering from obesity. Methods of administering such nutritional compositions are also provided.

Abstract translation: 液体营养组合物包括蛋白质，碳水化合物和脂肪的特定组合，用于具有特殊需要的个体的营养支持，例如患有肥胖的个体。 组合物包含至少一种ω-6脂肪酸的源和至少一种ω-6至ω-3的比例为1:5至1:1的ω-3脂肪酸的来源。 在优选形式中，组合物包含至少一种选自水解的乳清蛋白和水解酪蛋白的水解乳蛋白或其混合物。 还提供了施用这种营养组合物的方法。 另外的液体营养组合物包含液体营养组合物，维生素C和铜的1-12重量％的蛋白质，其中蛋白质包括乳清蛋白和酪蛋白与大部分具有水解度的乳清蛋白质的混合物 大于20％。 还提供了用于改善这些液体营养组合物中维生素C稳定性的方法。