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1.发明申请METHODS AND COMPOSITIONS FOR ATTENUATING MUSCLE PROTEIN DEGRADATION AND PRESERVING LEAN BODY MASS 审中-公开抑制肌肉蛋白质降解和保持身体质量的方法和组合物
公开(公告)号：WO2015095725A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/071539
申请日：2014-12-19
Applicant: ABBOTT LABORATORIES
Inventor： TIAN, Min , PEREIRA, Suzette , MUSTAD, Vikkie , CRAMER, Joel
CPC classification number: A23L33/115 , A23L33/10 , A23L33/30 , A23L33/40
Abstract: Methods and nutritional compositions are disclosed for attenuating muscle protein degradation, preserving lean body mass, or both in a subject in need thereof. Generally, the nutritional composition includes a source of fat, a source of protein, a source of carbohydrate, a source of β-hydroxy-β-methylbutyrate, at least one polyunsaturated fatty acid, at least one monounsaturated fatty acid, at least one vitamin, and at least one mineral. The nutritional composition also generally has from 10 grams to 25 grams of protein and from 240 kcal to 500 kcal per serving.
Abstract translation: 公开的方法和营养组合物用于减弱需要的受试者的肌肉蛋白质降解，保持瘦体重或两者。 通常，营养组合物包括脂肪源，蛋白质来源，碳水化合物源，β-羟基-β-甲基丁酸酯源，至少一种多不饱和脂肪酸，至少一种单不饱和脂肪酸，至少一种维生素 ，和至少一种矿物。 营养组合物还通常具有10克至25克蛋白质和240克卡至500千卡/份。
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2.发明申请METHODS FOR ENHANCING MOTOR FUNCTION, ENHANCING FUNCTIONAL STATUS AND MITIGATING MUSCLE WEAKNESS IN A SUBJECT 审中-公开提高电机功能，增强功能状态和减轻受试者肌肉疲劳的方法
公开(公告)号：WO2014099904A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/075649
申请日：2013-12-17
Applicant: ABBOTT LABORATORIES
Inventor： GARVEY, Sean , EDENS, Neile , WILLIAMS, Robert , MUSTAD, Vikkie , ULSTAD, David
IPC: A23L1/30 , A23L1/305 , A23L1/29 , A61H1/00 , A61H23/02 , A61N1/00 , A61K31/353 , A61P21/00 , A61K35/20
CPC classification number: A61K31/05 , A23L33/18 , A23L33/19 , A23L33/40 , A23V2002/00 , A61H1/005 , A61H23/00 , A61H99/00 , A61H2201/10 , A61K31/065 , A61K31/12 , A61K31/19 , A61K31/198 , A61K31/205 , A61K31/353 , A61K31/355 , A61K31/593 , A61K35/20 , A61K36/06 , A61K36/21 , A61K36/31 , A61K36/48 , A61K36/63 , A61K36/73 , A61K36/736 , A61K36/81 , A61K36/82 , A61K36/87 , A61K38/011 , A61K38/018 , A61K45/06 , A23V2200/316 , A23V2250/032 , A23V2250/1578 , A23V2250/1586 , A23V2250/1588 , A23V2250/1592 , A23V2250/1598 , A23V2250/1608 , A23V2250/161 , A23V2250/1612 , A23V2250/1618 , A23V2250/1626 , A23V2250/1642 , A23V2250/1842 , A23V2250/1872 , A23V2250/264 , A23V2250/304 , A23V2250/5036 , A23V2250/5054 , A23V2250/5114 , A23V2250/61 , A23V2250/628 , A23V2250/702 , A23V2250/7042 , A23V2250/7044 , A23V2250/7052 , A23V2250/7056 , A23V2250/706 , A23V2250/708 , A23V2250/7106 , A23V2250/712 , A23V2250/7142 , A23V2250/72 , A61K2300/00
Abstract: Methods for enhancing motor function, enhancing functional status, and mitigating muscle weakness in a subject are provided. The methods utilize the combination of administering to the subject a nutritional composition comprising at least one source of protein and applying a vibrational stimulus to the subject.
Abstract translation: 提供了增强运动功能，增强功能状态和减轻受试者肌肉无力的方法。 所述方法利用对受试者施用包含至少一种蛋白质的营养组合物并向受试者施加振动刺激的组合。
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公开(公告)号：WO2021216944A1
公开(公告)日：2021-10-28
申请号：PCT/US2021/028756
申请日：2021-04-23
Applicant: ABBOTT LABORATORIES
Inventor： PEREIRA, Suzette , RUEDA CABRERA, Ricardo , MUSTAD, Vikkie
IPC: A61K31/353 , A23G1/32 , A61P7/00
Abstract: Methods of increasing microvascular blood flow in the muscle of a human subject comprise orally administering about 100 to about 800 mg cocoa flavanols per day in a nutritional composition comprising at least one source of protein, to a subject in need of increased microvascular blood flow in the muscle.
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4.发明申请NUTRITIONAL COMPOSITIONS INCLUDING CALCIUM BETA-HYDROXY-BETA-METHYLBUTYRATE, PROTEIN AND LOW LEVELS OF ELECTROLYTES 审中-公开营养组合物，包括钙 - 羟基 - 甲基丁酸钙，蛋白质和低水平的电解质
公开(公告)号：WO2014047497A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/061014
申请日：2013-09-20
Applicant: ABBOTT LABORATORIES
Inventor： WALTON, Joseph , STEPP, Emily , DEVITT-MAICHER, Amy , WOLF, David , MUSTAD, Vikkie , BAXTER, Jeffrey , MAZER, Terrence , MARCHIO, Amy
CPC classification number: A61K31/19 , A23L2/38 , A23L2/66 , A23L33/12 , A23L33/16 , A23L33/18 , A23L33/185 , A23L33/19 , A23L33/21 , A23V2002/00 , A61K9/0095 , A61K31/202 , A61K31/22 , A61K31/7004 , A61K31/702 , A61K31/715 , A61K31/736 , A61K33/00 , A61K33/06 , A61K33/42 , A61K36/28 , A61K36/286 , A61K36/31 , A61K36/48 , A61K36/889 , A61K36/899 , A61K38/011 , A61K38/018 , A61K38/28 , A61K2300/00
Abstract: Disclosed are nutritional compositions, and methods of using and making the nutritional compositions, that include calcium beta-hydroxy-beta-methylbutyrate and protein. The calcium beta-hydroxy-beta-methylbutyrate is in sequestered or ion-exchanged form to reduce the interaction of the calcium with the protein in the nutritional composition and improve the overall stability of the nutritional composition.
Abstract translation: 公开了营养组合物，以及使用和制备营养组合物的方法，其包括β-羟基-β-甲基丁酸钙和蛋白质。 β-羟基-β-甲基丁酸钙是螯合或离子交换形式，以减少营养组合物中钙与蛋白质的相互作用，并提高营养组合物的整体稳定性。
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公开(公告)号：WO2020113048A1
公开(公告)日：2020-06-04
申请号：PCT/US2019/063669
申请日：2019-11-27
Applicant: ABBOTT LABORATORIES
Inventor： LÓPEZ PEDROSA, José María , RUEDA CABRERA, Ricardo , MANZANO MARTÍN, Manuel , GARCÍA MARTINEZ, Jorge , CAMPRUBÍ ROBLES, María , BUENO VARGAS, Pilar , WALTON, Joseph , MUSTAD, Vikkie
Abstract: A method of promoting healthy catch-up growth in a moderately malnourished individual is provided. The method includes administering to the moderately malnourished individual a nutritional composition that contains a carbohydrate blend, wherein the carbohydrate blend comprises a source of at least one carbohydrate that provides rapidly available glucose, a source of at least one carbohydrate that provides slowly available glucose, and a source of at least one non-digestible carbohydrate or resistant starch.
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Patent Agency Ranking6.发明申请NUTRITIONAL COMPOSITIONS INCLUDING CALCIUM BETA-HYDROXY-BETA-METHYLBUTYRATE AND PROTEIN 审中-公开含有β-羟基 - 甲基丁酸钙和蛋白质的营养组合物
公开(公告)号：WO2014047493A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/061009
申请日：2013-09-20
Applicant: ABBOTT LABORATORIES
Inventor： WALTON, Joseph , BAXTER, Jeffrey , MAZER, Terrence , ZOCHARSKI, Philip , LIPARI, John , KENSLER, Ann , EDENS, Neile , STEPP, Emily , DEVITT-MAICHER, Amy , WOLF, David , MUSTAD, Vikkie
CPC classification number: A61K9/107 , A23L33/10 , A23L33/40 , A23V2002/00 , A23V2200/00 , A23V2200/302 , A23V2200/316 , A23V2250/30
Abstract: Disclosed are nutritional compositions, and methods of using and making the nutritional compositions, that include calcium beta-hydroxy-beta-methylbutyrate and protein. The calcium beta-hydroxy-beta-methylbutyrate is in sequestered or ion-exchanged form to reduce the interaction of the calcium with the protein in the nutritional composition and improve the overall stability of the nutritional composition.
Abstract translation: 公开了营养组合物，以及使用和制备营养组合物的方法，其包括β-羟基-β-甲基丁酸钙和蛋白质。 β-羟基-β-甲基丁酸钙是螯合或离子交换形式，以减少营养组合物中钙与蛋白质的相互作用，并提高营养组合物的整体稳定性。
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7.发明申请COMPOSITION AND METHODS FOR NUTRITIONAL MANAGEMENT OF PATIENTS WITH HEPATIC DISEASE 审中-公开用于营养性疾病患者的组合物和方法
公开(公告)号：WO2005110124A1
公开(公告)日：2005-11-24
申请号：PCT/US2004/011550
申请日：2004-04-15
Applicant: ABBOTT LABORATORIES
Inventor： COMER, Gail, M. , CHENG, Lucia , MUSTAD, Vikkie , HUANG, Yung-Sheng , MCEWEN, John , DEMICHELE, Stephen, J. , BISTRIAN, Bruce, R.
IPC: A23L1/305
CPC classification number: A61K31/195 , A23L33/115 , A23L33/175 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K2300/00 , A23V2250/1882 , A23V2250/70 , A23V2250/156 , A23V2250/06 , A23V2250/5046 , A23V2250/54252 , A23V2250/264 , A23V2250/72
Abstract: This invention relates to compositions and methods for nutritional management of hepatic (liver) failure. In particular the invention is directed to a nutritionally complete formulation suitable for use as a supplement or total enteral feeding. The composition is specifically tailored to meet the requirements of hepatic patients in need of nutritional support. The composition comprises an organoleptically acceptable protein system designed to meet the altered metabolic needs of patients suffering from hepatic failure. The invention also relates to administering a nutritional composition comprising effective amounts of the branched-chain amino acids, valine, leucine, isoleucine, or mixtures thereof, and with or without a reduced amount of tyrosine, phenylalanine and tryptophan.
Abstract translation: 本发明涉及肝（肝）衰竭的营养管理的组合物和方法。 特别地，本发明涉及适合用作补充剂或总肠内喂养的营养完全的制剂。 该组合物专门为满足需要营养支持的肝脏患者的要求而定制。 该组合物包含设计用于满足患有肝衰竭的患者改变的代谢需要的感觉可接受的蛋白质系统。 本发明还涉及施用包含有效量的支链氨基酸，缬氨酸，亮氨酸，异亮氨酸或其混合物，以及有或没有减少量的酪氨酸，苯丙氨酸和色氨酸的营养组合物。
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公开(公告)号：EP3886906A1
公开(公告)日：2021-10-06
申请号：EP19821230.0
申请日：2019-11-27
Applicant: ABBOTT LABORATORIES
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公开(公告)号：EP4138814A1
公开(公告)日：2023-03-01
申请号：EP21724966.3
申请日：2021-04-23
Applicant: ABBOTT LABORATORIES
Inventor： PEREIRA, Suzette , RUEDA CABRERA, Ricardo , MUSTAD, Vikkie
IPC: A61K31/353 , A23G1/32 , A61P7/00
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10.发明公开NUTRITIONAL COMPOSITIONS INCLUDING CALCIUM BETA-HYDROXY-BETA-METHYLBUTYRATE, PROTEIN AND LOW LEVELS OF ELECTROLYTES 审中-公开ÄST FF AM AM ET UNG EN EN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN
公开(公告)号：EP2897472A1
公开(公告)日：2015-07-29
申请号：EP13771718.7
申请日：2013-09-20
Applicant: ABBOTT LABORATORIES
Inventor： WALTON, Joseph , STEPP, Emily , DEVITT-MAICHER, Amy , WOLF, David , MUSTAD, Vikkie , BAXTER, Jeffrey , MAZER, Terrence , MARCHIO, Amy
CPC classification number: A61K31/19 , A23L2/38 , A23L2/66 , A23L33/12 , A23L33/16 , A23L33/18 , A23L33/185 , A23L33/19 , A23L33/21 , A23V2002/00 , A61K9/0095 , A61K31/202 , A61K31/22 , A61K31/7004 , A61K31/702 , A61K31/715 , A61K31/736 , A61K33/00 , A61K33/06 , A61K33/42 , A61K36/28 , A61K36/286 , A61K36/31 , A61K36/48 , A61K36/889 , A61K36/899 , A61K38/011 , A61K38/018 , A61K38/28 , A61K2300/00
Abstract: Disclosed are nutritional compositions, and methods of using and making the nutritional compositions, that include calcium beta-hydroxy-beta-methylbutyrate and protein. The calcium beta-hydroxy-beta-methylbutyrate is in sequestered or ion-exchanged form to reduce the interaction of the calcium with the protein in the nutritional composition and improve the overall stability of the nutritional composition.
Abstract translation: 公开了营养组合物，以及使用和制备营养组合物的方法，其包括β-羟基-β-甲基丁酸钙和蛋白质。 β-羟基-β-甲基丁酸钙是螯合或离子交换形式，以减少营养组合物中钙与蛋白质的相互作用，并提高营养组合物的整体稳定性。
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