公开(公告)号：WO2014047497A1

公开(公告)日：2014-03-27

申请号：PCT/US2013/061014

申请日：2013-09-20

Applicant: ABBOTT LABORATORIES

Inventor： WALTON, Joseph ,  STEPP, Emily ,  DEVITT-MAICHER, Amy ,  WOLF, David ,  MUSTAD, Vikkie ,  BAXTER, Jeffrey ,  MAZER, Terrence ,  MARCHIO, Amy

IPC: A23L1/30 ,  A61K9/00 ,  A61K31/19 ,  A61P21/00

CPC classification number: A61K31/19 ,  A23L2/38 ,  A23L2/66 ,  A23L33/12 ,  A23L33/16 ,  A23L33/18 ,  A23L33/185 ,  A23L33/19 ,  A23L33/21 ,  A23V2002/00 ,  A61K9/0095 ,  A61K31/202 ,  A61K31/22 ,  A61K31/7004 ,  A61K31/702 ,  A61K31/715 ,  A61K31/736 ,  A61K33/00 ,  A61K33/06 ,  A61K33/42 ,  A61K36/28 ,  A61K36/286 ,  A61K36/31 ,  A61K36/48 ,  A61K36/889 ,  A61K36/899 ,  A61K38/011 ,  A61K38/018 ,  A61K38/28 ,  A61K2300/00

Abstract: Disclosed are nutritional compositions, and methods of using and making the nutritional compositions, that include calcium beta-hydroxy-beta-methylbutyrate and protein. The calcium beta-hydroxy-beta-methylbutyrate is in sequestered or ion-exchanged form to reduce the interaction of the calcium with the protein in the nutritional composition and improve the overall stability of the nutritional composition.

Abstract translation: 公开了营养组合物，以及使用和制备营养组合物的方法，其包括β-羟基-β-甲基丁酸钙和蛋白质。 β-羟基-β-甲基丁酸钙是螯合或离子交换形式，以减少营养组合物中钙与蛋白质的相互作用，并提高营养组合物的整体稳定性。

公开(公告)号：WO2014099795A1

公开(公告)日：2014-06-26

申请号：PCT/US2013/075412

申请日：2013-12-16

Applicant: ABBOTT LABORATORIES

Inventor： CHAPMAN, Timothy ,  DEWILLE, Normanella ,  LOWE, Kelley ,  MAZER, Terrence

IPC: A23C9/15 ,  A23L2/66 ,  A23L1/29 ,  A61K38/01

CPC classification number: A23L2/52 ,  A23C9/15 ,  A23L2/66 ,  A23L33/00 ,  A23L33/18 ,  A23L33/19 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/33 ,  A23V2250/032 ,  A23V2250/0612 ,  A23V2250/0644 ,  A23V2250/156 ,  A23V2250/1882 ,  A23V2250/5046 ,  A23V2250/5424 ,  A23V2250/54246 ,  A23V2250/702 ,  A23V2250/704 ,  A23V2250/7106

Abstract: Disclosed embodiments provide low viscosity, high caloric density liquid nutritional compositions. The use of non-micellar milk protein in combination with hydrolyzed caseinate and unique formulation methods allow for improved organoleptic qualities and the production of liquid nutritional compositions displaying low viscosity along with a high caloric density.

Abstract translation: 公开的实施方案提供了低粘度，高热量密度的液体营养组合物。 使用非胶束乳蛋白与水解的酪蛋白酸盐和独特的制剂方法相结合，可以提高显示低粘度和高热量密度的感官质量和液体营养组合物的生产。

公开(公告)号：WO2014066682A1

公开(公告)日：2014-05-01

申请号：PCT/US2013/066680

申请日：2013-10-24

Applicant: ABBOTT LABORATORIES ,  ABBOTT GMBH & CO. KG

Inventor： MAZER, Terrence ,  KESSLER, Thomas ,  DEWILLE, Normanella ,  WEARLY, Douglas ,  HEO, Youngsuk ,  WESTEDT, Ulrich ,  KATZ, Gary ,  LAU, Eik-Lang

IPC: A23P1/02 ,  A23C11/00 ,  A23C13/12 ,  A23L2/39 ,  A23P1/12

CPC classification number: A23L2/395 ,  A23L3/44 ,  A23L33/15 ,  A23L33/155 ,  A23L33/40 ,  A23P10/22 ,  A23P10/25 ,  A23P30/20 ,  A23V2002/00

Abstract: Extruded nutritional powders and methods of manufacturing the extruded nutritional powders, including extruded infant nutritional powders and extruded adult nutritional powders are provided. The processes utilize an extruder that is capable of internally mixing and emulsifying protein, and optionally, a carbohydrate with fat and water into an emulsion that can be dried into a powder having equivalent fat separation and dispersibility as compared to spray dried powders.

Abstract translation: 提供了挤出的营养粉末和制造挤出的营养粉末的方法，包括挤出的婴儿营养粉末和挤出的成人营养粉末。 该方法利用能够内部混合和乳化蛋白质的挤出机，并且任选地，将含有脂肪和水的碳水化合物加入乳液中，与喷雾干燥的粉末相比，可将其干燥成具有等效脂肪分离和分散性的粉末。

公开(公告)号：WO2014047493A1

公开(公告)日：2014-03-27

申请号：PCT/US2013/061009

申请日：2013-09-20

Applicant: ABBOTT LABORATORIES

Inventor： WALTON, Joseph ,  BAXTER, Jeffrey ,  MAZER, Terrence ,  ZOCHARSKI, Philip ,  LIPARI, John ,  KENSLER, Ann ,  EDENS, Neile ,  STEPP, Emily ,  DEVITT-MAICHER, Amy ,  WOLF, David ,  MUSTAD, Vikkie

IPC: A23L1/30 ,  A61K9/00 ,  A61K31/19

CPC classification number: A61K9/107 ,  A23L33/10 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A23V2200/302 ,  A23V2200/316 ,  A23V2250/30

Abstract: Disclosed are nutritional compositions, and methods of using and making the nutritional compositions, that include calcium beta-hydroxy-beta-methylbutyrate and protein. The calcium beta-hydroxy-beta-methylbutyrate is in sequestered or ion-exchanged form to reduce the interaction of the calcium with the protein in the nutritional composition and improve the overall stability of the nutritional composition.

Abstract translation: 公开了营养组合物，以及使用和制备营养组合物的方法，其包括β-羟基-β-甲基丁酸钙和蛋白质。 β-羟基-β-甲基丁酸钙是螯合或离子交换形式，以减少营养组合物中钙与蛋白质的相互作用，并提高营养组合物的整体稳定性。

公开(公告)号：WO2015053789A1

公开(公告)日：2015-04-16

申请号：PCT/US2013/064659

申请日：2013-10-11

Applicant: ABBOTT LABORATORIES

Inventor： DEWILLE, Normanella ,  CABRERA, Ricardo Rueda ,  MARRIAGE, Barbara ,  SHERRY, Christina ,  WEARLY, Douglas ,  PEDROSA, Jose Maria Lopez ,  BLUMBERG, Rachel ,  MAZER, Terrence

IPC: A23L1/30 ,  A23L1/305 ,  A23L1/308 ,  A23L2/52 ,  A23L2/66 ,  A23L1/09 ,  A23L1/29

CPC classification number: A23L1/296 ,  A23L2/52 ,  A23L2/66 ,  A23L5/00 ,  A23L29/30 ,  A23L33/115 ,  A23L33/12 ,  A23L33/125 ,  A23L33/17 ,  A23L33/21 ,  A23L33/40 ,  A23V2002/00

Abstract: The present disclosure is directed to a nutritional powder, a translucent reconstitutable beverage formed therefrom, and methods relating thereto. The nutritional powder and beverage are adapted to include the proper balance of proteins, lipids, carbohydrates, vitamins and minerals appropriate for a pregnant woman. The nutritional compositions further stem the glycemic response and improve glycemia and insulinemia during gestational and lactating periods for preventing or reduce the incidence of glucose intolerance later in life.

Abstract translation: 本公开涉及营养粉末，由其形成的半透明可再生饮料以及与其相关的方法。 营养粉末和饮料适于包括适合于孕妇的蛋白质，脂质，碳水化合物，维生素和矿物质的适当平衡。 营养组合物进一步阻止血糖反应，并改善妊娠期和哺乳期期间的血糖和胰岛素血症，以预防或减少生命后期葡萄糖不耐受的发生。

公开(公告)号：WO2014164956A1

公开(公告)日：2014-10-09

申请号：PCT/US2014/023919

申请日：2014-03-12

Applicant: ABBOTT LABORATORIES

Inventor： WEARLY, Douglas ,  LAU, Eik-Lang ,  MAZER, Terrence ,  DEWILLE, Normanella ,  KATZ, Gary ,  FOX, Wendy

IPC: A23L3/18 ,  A23P1/12

CPC classification number: A23L3/18 ,  A23L3/015 ,  A23L3/3571 ,  A23P30/20 ,  A23V2002/00 ,  A23V2300/16

Abstract: A method of reducing a pathogenic microorganism population in a powdered nutritional food composition is described herein. The powdered nutritional food composition includes a fat, a protein, and a carbohydrate. The method includes forming an emulsion of the powdered nutritional food composition and extruding the emulsified powdered nutritional food composition at a temperature of less than about 100°C. The method produces at least a 5 log reduction in the pathogenic microorganism population in the extruded powdered nutritional food composition. The extruded powdered nutritional food composition has a water activity level of about 0.3 to about 0.95.

Abstract translation: 本文描述了在粉末状营养食品组合物中降低致病微生物群体的方法。 粉状营养食品组合物包括脂肪，蛋白质和碳水化合物。 该方法包括形成粉状营养食品组合物的乳液并在小于约100℃的温度下挤出乳化粉状营养食品组合物。 该方法在挤出的粉状营养食品组合物中产生至少5对数的病原微生物群体。 挤出的粉状营养食品组合物的水活度水平为约0.3至约0.95。

公开(公告)号：WO2014100088A1

公开(公告)日：2014-06-26

申请号：PCT/US2013/075952

申请日：2013-12-18

Applicant: ABBOTT LABORATORIES

Inventor： VURMA, Mustafa ,  BARRETT-REIS, Bridget ,  MAZER, Terrence ,  COMMARE, Coryn ,  HRONCICH, Maggie ,  BOFF, Jeffrey

IPC: A23L1/30 ,  A23L1/305 ,  A23L1/29 ,  A61K36/282 ,  A61P39/06

CPC classification number: A61K36/28 ,  A23L33/105 ,  A23L33/115 ,  A23L33/12 ,  A23L33/15 ,  A23L33/16 ,  A23L33/18 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/30 ,  A23V2250/0612 ,  A23V2250/1588 ,  A23V2250/1592 ,  A23V2250/16 ,  A23V2250/1614 ,  A23V2250/1626 ,  A23V2250/1642 ,  A23V2250/211 ,  A23V2250/304 ,  A23V2250/5054 ,  A23V2250/5118 ,  A23V2250/54246 ,  A23V2250/641 ,  A23V2250/702 ,  A23V2250/7044 ,  A23V2250/7046 ,  A23V2250/7056 ,  A23V2250/706 ,  A23V2250/71 ,  A23V2250/712 ,  A23V2250/72

Abstract: The present invention is directed to concentrated liquid human milk fortifiers using extensively hydrolyzed casein as a protein source, a stabilizer system comprising octenyl succinic anhydride modified corn starch in combination with a low acyl gellan gum, and the carotenoid lutein.

Abstract translation: 本发明涉及使用广泛水解的酪蛋白作为蛋白质源的浓缩液体人乳强化剂，包含辛烯基琥珀酸酐改性玉米淀粉与低级酰基结冷胶的组合的稳定剂体系和类胡萝卜素叶黄素。

公开(公告)号：WO2014093832A1

公开(公告)日：2014-06-19

申请号：PCT/US2013/075029

申请日：2013-12-13

Applicant: ABBOTT LABORATORIES ,  ABBOTT GMBH & CO. KG

Inventor： MAZER, Terrence ,  KESSLER, Thomas

IPC: A23P1/12 ,  A23L1/00 ,  B01F3/08

CPC classification number: A23P1/12 ,  A23L33/40 ,  A23L35/10 ,  A23P10/40 ,  A23P30/20 ,  A23V2002/00 ,  B01F3/0807 ,  B01F7/00641 ,  B01F7/082 ,  B01F7/105

Abstract: A method of producing an emulsion and an extrudate for a powdered nutritional product is provided. The method includes utilizing an extruder (10) that contains a high shear element (32) positioned within the barrel of the extruder (20). The use of a high shear element (32) positioned within the barrel of the extruder (20) allows both emulsification and extrusion of the ingredients to occur within the barrel of the extruder (20). A first portion of ingredients comprising a slurry is processed by the high shear element (32) to form an emulsion. The emulsion is then combined with a second portion of ingredients and extruded to form an extrudate for the desired powdered nutritional product. In some embodiments, the high shear element (32) may comprise a shearing disc or a pair of shearing discs. The extruder (10) may comprise a single screw extruder, a twin screw extruder, or any other suitable type of extruder.

Abstract translation: 提供了制备粉状营养产品的乳液和挤出物的方法。 该方法包括利用包含位于挤出机（20）的筒内的高剪切元件（32）的挤出机（10）。 使用位于挤出机（20）的筒内的高剪切元件（32）允许在挤出机（20）的桶内发生成分的乳化和挤出。 包含浆料的成分的第一部分由高剪切元件（32）处理以形成乳液。 然后将乳液与成分的第二部分组合并挤出以形成所需粉末营养产品的挤出物。 在一些实施例中，高剪切元件（32）可以包括剪切盘或一对剪切盘。 挤出机（10）可以包括单螺杆挤出机，双螺杆挤出机或任何其它合适类型的挤出机。

公开(公告)号：WO2014066680A1

公开(公告)日：2014-05-01

申请号：PCT/US2013/066678

申请日：2013-10-24

Applicant: ABBOTT LABORATORIES ,  ABBOTT GMBH & CO. KG

Inventor： LAU, Eik-Lang ,  WEARLY, Douglas ,  KATZ, Gary ,  HEO, Youngsuk ,  MAZER, Terrence ,  DEWILLE, Normanella ,  WESTEDT, Ulrich ,  KESSLER, Thomas

IPC: A23P1/02 ,  A23L2/39 ,  A23P1/12 ,  A23L1/00

CPC classification number: A23L2/395 ,  A23L3/44 ,  A23L33/15 ,  A23L33/155 ,  A23L33/40 ,  A23P10/22 ,  A23P10/25 ,  A23P30/20 ,  A23V2002/00

Abstract: Extruded nutritional powders and methods of manufacturing the extruded nutritional powders, including extruded infant nutritional powders and extruded adult nutritional powders are provided. The processes utilize an extruder that is capable of internally mixing and emulsifying protein, and optionally, a carbohydrate with fat and water into an emulsion that can be dried into a powder having equivalent fat separation and dispersibility as compared to spray dried powders.

Abstract translation: 提供了挤出的营养粉末和制造挤出的营养粉末的方法，包括挤出的婴儿营养粉末和挤出的成人营养粉末。 该方法利用能够内部混合和乳化蛋白质的挤出机，并且任选地，将含有脂肪和水的碳水化合物加入乳液中，与喷雾干燥的粉末相比，可将其干燥成具有等效脂肪分离和分散性的粉末。

公开(公告)号：EP2934186A1

公开(公告)日：2015-10-28

申请号：EP13817819.9

申请日：2013-12-18

Applicant: ABBOTT LABORATORIES

Inventor： VURMA, Mustafa ,  BARRETT-REIS, Bridget ,  MAZER, Terrence ,  COMMARE, Coryn ,  HRONCICH, Maggie ,  BOFF, Jeffrey

IPC: A23L1/30 ,  A23L1/305 ,  A23L1/29 ,  A61K36/282 ,  A61P39/06

CPC classification number: A61K36/28 ,  A23L33/105 ,  A23L33/115 ,  A23L33/12 ,  A23L33/15 ,  A23L33/16 ,  A23L33/18 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/30 ,  A23V2250/0612 ,  A23V2250/1588 ,  A23V2250/1592 ,  A23V2250/16 ,  A23V2250/1614 ,  A23V2250/1626 ,  A23V2250/1642 ,  A23V2250/211 ,  A23V2250/304 ,  A23V2250/5054 ,  A23V2250/5118 ,  A23V2250/54246 ,  A23V2250/641 ,  A23V2250/702 ,  A23V2250/7044 ,  A23V2250/7046 ,  A23V2250/7056 ,  A23V2250/706 ,  A23V2250/71 ,  A23V2250/712 ,  A23V2250/72

Abstract: The present invention is directed to concentrated liquid human milk fortifiers using extensively hydrolyzed casein as a protein source, a stabilizer system comprising octenyl succinic anhydride modified corn starch in combination with a low acyl gellan gum, and the carotenoid lutein.