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1.发明公开LHRH ANTAGONISTS HAVING MODIFIED AMINOACYL RESIDUES AT POSTIONS 5 AND 6 失效与LHRH antagoniste修改后的实体TO THE 5位和第6
公开(公告)号：EP0683792A1
公开(公告)日：1995-11-29
申请号：EP94905391.0
申请日：1993-12-14
Applicant: ABBOTT LABORATORIES
Inventor： HAVIV, Fortuna , GREER, Jonathan , SWENSON, Rolf E. , SAUER, Daryl R.
Abstract: A class of potent LHRH decapeptide antagonists possess N-alkylated aminoacyl residues where the side-chain portion of the residue is a 4-(substituted-amino)phenylalanyl, 4-(substituted-amino)cyclohexylalanyl, or Φ-(substituted-amino)alkyl group, and additionally the aminoacyl residues at position 5 are N-alkylated on the nitrogen atom of the peptide backbone.
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公开(公告)号：EP2069351A2
公开(公告)日：2009-06-17
申请号：EP07784490.0
申请日：2007-06-20
Applicant: ABBOTT LABORATORIES
Inventor： PENNING, Thomas D. , THOMAS, Sheela A. , HAJDUK, Philip J. , SAUER, Daryl R. , SARRIS, Kathy , GIRANDA, Vincent L.
IPC: C07D487/04 , A61K31/519
CPC classification number: C07D487/04
Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
Abstract translation: 本发明涉及式（I）的1H-苯并咪唑-4-甲酰胺，它们的制备以及它们作为用于制备药物的聚（ADP-核糖）聚合酶聚合酶的抑制剂的用途。
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3.发明授权LHRH ANTAGONISTS HAVING MODIFIED AMINOACYL RESIDUES AT POSTIONS 5 AND 6 失效LHRH拮抗剂WITH改性氨TO THE 5和6位
公开(公告)号：EP0683792B1
公开(公告)日：2001-09-26
申请号：EP94905391.2
申请日：1993-12-14
Applicant: ABBOTT LABORATORIES
Inventor： HAVIV, Fortuna , GREER, Jonathan , SWENSON, Rolf E. , SAUER, Daryl R.
Abstract: A class of potent LHRH decapeptide antagonists possess N-alkylated aminoacyl residues where the side-chain portion of the residue is a 4-(substituted-amino)phenylalanyl, 4-(substituted-amino)cyclohexylalanyl, or OMEGA -(substituted-amino)alkyl group, and additionally the aminoacyl residues at position 5 are N-alkylated on the nitrogen atom of the peptide backbone.
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