公开(公告)号：WO2008154241A1

公开(公告)日：2008-12-18

申请号：PCT/US2008/065727

申请日：2008-06-04

Applicant: ABBOTT LABORATORIES ,  AKRITOPOULOU-ZANZE, Irini ,  WAKEFIELD, Brian D ,  MACK, Helmut ,  TURNER, Sean C ,  GASIECKI, Alan F ,  GRACIAS, Vijaya J ,  SARRIS, Kathy ,  KALVIN, Douglas M ,  MICHMERHUIZEN, Melissa J ,  SHUAI, Qi ,  PATEL, Jyoti R ,  BAKKER, Margaretha ,  TEUSCH, Nicole ,  JOHNSON, Eric T ,  KOVAR, Peter J ,  DJURIC, Stevan W ,  LONG, Andrew J ,  VASUDEVAN, Anil ,  HOBSON, Adrian ,  ST. JOHN MOORE, Nigel ,  WANG, Lu ,  GEORGE, Dawn ,  LI, Biqin ,  FRANK, Kristine

Inventor： AKRITOPOULOU-ZANZE, Irini ,  WAKEFIELD, Brian D ,  MACK, Helmut ,  TURNER, Sean C ,  GASIECKI, Alan F ,  GRACIAS, Vijaya J ,  SARRIS, Kathy ,  KALVIN, Douglas M ,  MICHMERHUIZEN, Melissa J ,  SHUAI, Qi ,  PATEL, Jyoti R ,  BAKKER, Margaretha ,  TEUSCH, Nicole ,  JOHNSON, Eric T ,  KOVAR, Peter J ,  DJURIC, Stevan W ,  LONG, Andrew J ,  VASUDEVAN, Anil ,  HOBSON, Adrian ,  ST. JOHN MOORE, Nigel ,  WANG, Lu ,  GEORGE, Dawn ,  LI, Biqin ,  FRANK, Kristine

IPC: C07D403/04 ,  C07D413/04 ,  C07D417/04

CPC classification number: C07D403/04 ,  C07D413/04 ,  C07D417/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R 1 , R 2 , R 3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中A，R 1，R 2，R 3和m在说明书中定义。 本发明还涉及制备所述化合物的方法和含有所述化合物的组合物，其可用于抑制激酶如糖原合酶激酶3（GSK-3），Rho激酶（ROCK），Janus激酶（JAK），AKT，PAK4 ，PLK，CK2，KDR，MK2，JNK1，极光，pim1和nek2。

公开(公告)号：WO2012051361A1

公开(公告)日：2012-04-19

申请号：PCT/US2011/056045

申请日：2011-10-12

Applicant: ABBOTT LABORATORIES ,  DEGOEY, David A. ,  KATI, Warren M. ,  HUTCHINS, Charles W. ,  DONNER, Pamela L. ,  KRUEGER, Allan C. ,  RANDOLPH, John T. ,  MOTTER, Christopher E. ,  NELSON, Lissa T. ,  PATEL, Sachel V. ,  MATULENKO, Mark A. ,  KEDDY, Ryan G. ,  JINKERSON, Tammie K. ,  GAO, Yi ,  LIU, Dachun ,  PRATT, John K. ,  ROCKWAY, Todd W. ,  MARING, Clarence J. ,  HUTCHINSON, Douglas K. ,  FLENTGE, Charles A. ,  WAGNER, Rolf ,  TUFANO, Michael D. ,  BETEBENNER, David A. ,  SARRIS, Kathy ,  WOLLER, Kevin R. ,  WAGAW, Sebel H. ,  CALIFANO, Jean C. ,  LI, Wenke ,  CASPI, Daniel D. ,  BELLIZZI, Mary E. ,  CARROLL, William A.

Inventor： DEGOEY, David A. ,  KATI, Warren M. ,  HUTCHINS, Charles W. ,  DONNER, Pamela L. ,  KRUEGER, Allan C. ,  RANDOLPH, John T. ,  MOTTER, Christopher E. ,  NELSON, Lissa T. ,  PATEL, Sachel V. ,  MATULENKO, Mark A. ,  KEDDY, Ryan G. ,  JINKERSON, Tammie K. ,  GAO, Yi ,  LIU, Dachun ,  PRATT, John K. ,  ROCKWAY, Todd W. ,  MARING, Clarence J. ,  HUTCHINSON, Douglas K. ,  FLENTGE, Charles A. ,  WAGNER, Rolf ,  TUFANO, Michael D. ,  BETEBENNER, David A. ,  SARRIS, Kathy ,  WOLLER, Kevin R. ,  WAGAW, Sebel H. ,  CALIFANO, Jean C. ,  LI, Wenke ,  CASPI, Daniel D. ,  BELLIZZI, Mary E. ,  CARROLL, William A.

IPC: C07D403/14

CPC classification number: A61K31/454 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/438 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D491/113 ,  C07F7/02 ,  Y02P20/582

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (HCV) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Abstract translation: 描述了有效抑制丙型肝炎病毒（HCV）复制的化合物。 本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。

公开(公告)号：WO2009039127A1

公开(公告)日：2009-03-26

申请号：PCT/US2008/076576

申请日：2008-09-17

Applicant: ABBOTT LABORATORIES ,  WAGNER, Rolf ,  TUFANO, Michael D. ,  STEWART, Kent D. ,  ROCKWAY, Todd W. ,  RANDOLPH, John T. ,  PRATT, John K. ,  MOTTER, Christopher E. ,  MARING, Clarence J. ,  LONGENECKER, Kenton L. ,  LIU, Yaya ,  LIU, Dachun ,  KRUEGER, Allan C. ,  KATI, Warren M. ,  HUTCHINSON, Douglas K. ,  HUANG, Peggy P. ,  FLENTGE, Charles A. ,  DONNER, Pamela L. ,  DEGOEY, David A. ,  BETEBENNER, David A. ,  BARNES, David M. ,  CHEN, Shuang ,  FRANCZYK II, Thaddeus S. ,  GAO, Yi ,  HAIGHT, Anthony R. ,  HENGEVELD, John E. ,  HENRY, Rodger F. ,  KOTECKI, Brian J. ,  LOU, Xiaochun ,  SARRIS, Kathy ,  ZHANG, Geoff G. Z.

Inventor： WAGNER, Rolf ,  TUFANO, Michael D. ,  STEWART, Kent D. ,  ROCKWAY, Todd W. ,  RANDOLPH, John T. ,  PRATT, John K. ,  MOTTER, Christopher E. ,  MARING, Clarence J. ,  LONGENECKER, Kenton L. ,  LIU, Yaya ,  LIU, Dachun ,  KRUEGER, Allan C. ,  KATI, Warren M. ,  HUTCHINSON, Douglas K. ,  HUANG, Peggy P. ,  FLENTGE, Charles A. ,  DONNER, Pamela L. ,  DEGOEY, David A. ,  BETEBENNER, David A. ,  BARNES, David M. ,  CHEN, Shuang ,  FRANCZYK II, Thaddeus S. ,  GAO, Yi ,  HAIGHT, Anthony R. ,  HENGEVELD, John E. ,  HENRY, Rodger F. ,  KOTECKI, Brian J. ,  LOU, Xiaochun ,  SARRIS, Kathy ,  ZHANG, Geoff G. Z.

IPC: C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61P31/12 ,  A61K31/513

CPC classification number: A61K31/513 ,  A61K31/5377 ,  C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/14

Abstract: Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4-dihydropyrimidin-1 (2H)- y!)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-methoxy-styryl- phenyl)methanesulfonamide.

Abstract translation: 本申请涉及可用于治疗丙型肝炎（HCV）感染的式I化合物。 所公开的化合物的结构是通过亚苯基连接成稠合的2-环环系（R6）或者另外通过另外的两个原子连接基（L）与5-6元单环（R6）连接的尿嘧啶或胸腺嘧啶衍生物。 应用进一步公开了两种特定化合物的多晶型物和假多晶型物：N-（6（3-叔丁基-5-（2,4-二氧代-3,4-二氢嘧啶-1（2H） - 基）-2-甲氧基 - 苯基 ）萘-2-基）甲磺酰胺和（E）-N-（4（3-叔丁基-5-（2,4-二氧代-3）4-二氢嘧啶-1（2H） - 基）2-甲氧基 - 苯乙烯基 - 苯基）甲磺酰胺。

公开(公告)号：WO2010144646A3

公开(公告)日：2010-12-16

申请号：PCT/US2010/038077

申请日：2010-06-10

Applicant: ABBOTT LABORATORIES ,  DEGOEY, David A. ,  KATI, Warren M. ,  HUTCHINS, Charles W. ,  DONNER, Pamela L. ,  KRUEGER, Allan C. ,  RANDOLPH, John T. ,  MOTTER, Christopher E. ,  NELSON, Lissa T. ,  PATEL, Sachin V. ,  MATULENKO, Mark A. ,  KEDDY, Ryan G. ,  JINKERSON, Tammie K. ,  SOLTWEDEL, Todd N. ,  HUTCHINSON, Douglas K. ,  FLENTGE, Charles A. ,  WAGNER, Rolf ,  MARING, Clarence J. ,  TUFANO, Michael D. ,  BETEBENNER, David A. ,  ROCKWAY, Todd W. ,  LIU, Dachun ,  PRATT, John K. ,  LAVIN, Michael J. ,  SARRIS, Kathy ,  WOLLER, Kevin R. ,  WAGAW, Seble H. ,  CALIFANO, Jean C. ,  LI, Wenke ,  CASPI, Daniel, D. ,  BELLIZZI, Mary, E.

Inventor： DEGOEY, David A. ,  KATI, Warren M. ,  HUTCHINS, Charles W. ,  DONNER, Pamela L. ,  KRUEGER, Allan C. ,  RANDOLPH, John T. ,  MOTTER, Christopher E. ,  NELSON, Lissa T. ,  PATEL, Sachin V. ,  MATULENKO, Mark A. ,  KEDDY, Ryan G. ,  JINKERSON, Tammie K. ,  SOLTWEDEL, Todd N. ,  HUTCHINSON, Douglas K. ,  FLENTGE, Charles A. ,  WAGNER, Rolf ,  MARING, Clarence J. ,  TUFANO, Michael D. ,  BETEBENNER, David A. ,  ROCKWAY, Todd W. ,  LIU, Dachun ,  PRATT, John K. ,  LAVIN, Michael J. ,  SARRIS, Kathy ,  WOLLER, Kevin R. ,  WAGAW, Seble H. ,  CALIFANO, Jean C. ,  LI, Wenke ,  CASPI, Daniel, D. ,  BELLIZZI, Mary, E.

IPC: C07D403/14 ,  C07D401/14 ,  C07D417/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/4439 ,  A61P31/14

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：WO2009070516A1

公开(公告)日：2009-06-04

申请号：PCT/US2008/084469

申请日：2008-11-24

Applicant: ABBOTT LABORATORIES ,  BAMAUNG, Nwe Y. ,  BELL, Randy L. ,  CLARK, Richard F. ,  ERICKSON, Scott A. ,  FIDANZE, Steve D. ,  HUBBARD, Robert D. ,  MANTEI, Robert A. ,  SHEPPARD, George S. ,  SORENSEN, Bryan K. ,  WANG, Gary T. ,  WANG, Jieyi ,  SARRIS, Kathy

Inventor： BAMAUNG, Nwe Y. ,  BELL, Randy L. ,  CLARK, Richard F. ,  ERICKSON, Scott A. ,  FIDANZE, Steve D. ,  HUBBARD, Robert D. ,  MANTEI, Robert A. ,  SHEPPARD, George S. ,  SORENSEN, Bryan K. ,  WANG, Gary T. ,  WANG, Jieyi ,  SARRIS, Kathy

IPC: C07D513/04 ,  A61K31/425 ,  A61P35/00

CPC classification number: C07D513/04

Abstract: Compounds of formula I that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula I and therapeutically acceptable salts, prodrugs and salts of prodrugs thereof, wherein X is CH or N; A 1 is R 1 , OR 1 . NHR 1 , N(R 1 ) 2, NHC(O)R 1 , NHC(O)NHR 1 , NHC(O)N(R 1 ) 2 , NHC(O)OR 1 , C(O)NHR 1 , C(O)N(R 1 ) 2 , C=NOR 1 , or C(NH 2 )NOC(O)R 1 ;

Abstract translation: 公开了抑制蛋白激酶的式I化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。 式I及其前药的其治疗上可接受的盐，前药和盐，其中X为CH或N; A1为R1，OR1。 NH（O）N（R1）2，NHC（O）R1，NHC（O）NHR1，NHC（O）N（R1）2，NHC（O）OR1，C（O）NHR1，C（O） 2，C = NOR1或C（NH 2）NOC（O）R 1;

公开(公告)号：WO2007149907A2

公开(公告)日：2007-12-27

申请号：PCT/US2007/071649

申请日：2007-06-20

Applicant: ABBOTT LABORATORIES ,  PENNING, Thomas, D. ,  THOMAS, Sheela, A. ,  HAJDUK, Philip, J. ,  SAUER, Daryl, R. ,  SARRIS, Kathy ,  GIRANDA, Vincent, L.

Inventor： PENNING, Thomas, D. ,  THOMAS, Sheela, A. ,  HAJDUK, Philip, J. ,  SAUER, Daryl, R. ,  SARRIS, Kathy ,  GIRANDA, Vincent, L.

IPC: C07D487/04 ,  A61K31/519

CPC classification number: C07D487/04

Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.

Abstract translation: 本发明涉及式（I）的1H-苯并咪唑-4-甲酰胺，其制备及其作为制备药物的聚（ADP-核糖）聚合酶的抑制剂的用途。

公开(公告)号：EP2222646A1

公开(公告)日：2010-09-01

申请号：EP08831873.8

申请日：2008-09-17

Applicant: Abbott Laboratories

Inventor： WAGNER, Rolf ,  TUFANO, Michael D. ,  STEWART, Kent D. ,  ROCKWAY, Todd W. ,  RANDOLPH, John T. ,  PRATT, John K. ,  MOTTER, Christopher E. ,  MARING, Clarence J. ,  LONGENECKER, Kenton L. ,  LIU, Yaya ,  LIU, Dachun ,  KRUEGER, Allan C. ,  KATI, Warren M. ,  HUTCHINSON, Douglas K. ,  HUANG, Peggy P. ,  FLENTGE, Charles A. ,  DONNER,Pamela L. ,  DEGOEY, David A. ,  BETEBENNER, David A. ,  BARNES, David M. ,  CHEN, Shuang ,  FRANCZYK II, Thaddeus S. ,  GAO, Yi ,  HAIGHT, Anthony R. ,  HENGEVELD, John E. ,  HENRY, Rodger F. ,  KOTECKI, Brian J. ,  LOU, Xiaochun ,  SARRIS, Kathy ,  ZHANG, Geoff G. Z.

IPC: C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61P31/12 ,  A61K31/513

CPC classification number: A61K31/513 ,  A61K31/5377 ,  C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/14

Abstract: Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4-dihydropyrimidin-1 (2H)- y!)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-methoxy-styryl- phenyl)methanesulfonamide.

公开(公告)号：EP2222682A1

公开(公告)日：2010-09-01

申请号：EP08855224.5

申请日：2008-11-24

Applicant: Abbott Laboratories

Inventor： BAMAUNG, Nwe Y. ,  BELL, Randy L. ,  CLARK, Richard F. ,  ERICKSON, Scott A. ,  FIDANZE, Steve D. ,  HUBBARD, Robert D. ,  MANTEI, Robert A. ,  SHEPPARD, George S. ,  SORENSEN, Bryan K. ,  WANG, Gary T. ,  WANG, Jieyi ,  SARRIS, Kathy

IPC: C07D513/04 ,  A61K31/425 ,  A61P35/00

CPC classification number: C07D513/04

Abstract: Compounds of formula I that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula I and therapeutically acceptable salts, prodrugs and salts of prodrugs thereof, wherein X is CH or N; A1 is R1, OR1. NHR1, N(R1)2, NHC(O)R1, NHC(O)NHR1, NHC(O)N(R1)2, NHC(O)OR1, C(O)NHR1, C(O)N(R1)2, C=NOR1, or C(NH2)NOC(O)R1;

公开(公告)号：EP2337781A2

公开(公告)日：2011-06-29

申请号：EP10724656.3

申请日：2010-06-10

Applicant: Abbott Laboratories

Inventor： RANDOLPH, John T. ,  DEGOEY, David A. ,  KATI, Warren M. ,  HUTCHINS, Charles W. ,  DONNER, Pamela L. ,  KRUEGER, Allan C. ,  MOTTER, Christopher E. ,  NELSON, Lissa T. ,  PATEL, Sachin V. ,  MATULENKO, Mark A. ,  KEDDY, Ryan G. ,  JINKERSON, Tammie K. ,  SOLTWEDEL, Todd N. ,  HUTCHINSON, Douglas K. ,  FLENTGE, Charles A. ,  WAGNER, Rolf ,  MARING, Clarence J. ,  TUFANO, Michael D. ,  BETEBENNER, David A. ,  ROCKWAY, Todd W. ,  LIU, Dachun ,  PRATT, John K. ,  LAVIN, Michael J. ,  SARRIS, Kathy ,  WOLLER, Kevin R. ,  WAGAW, Seble H. ,  CALIFANO, Jean C. ,  LI, Wenke ,  CASPI, Daniel.D. ,  BELLIZZI, Mary, E.

IPC: C07D403/14 ,  C07D401/14 ,  C07D417/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/4439 ,  A61P31/14

CPC classification number: C07F9/65583 ,  C07C33/26 ,  C07C201/06 ,  C07C205/19 ,  C07D207/08 ,  C07D207/09 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D471/04 ,  C07D491/113 ,  C07K5/06

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：EP2167491A1

公开(公告)日：2010-03-31

申请号：EP08770094.4

申请日：2008-06-04

Applicant: Abbott Laboratories ,  Abbott GmbH & Co. KG

Inventor： AKRITOPOULOU-ZANZE, Irini ,  WAKEFIELD, Brian D ,  MACK, Helmut ,  TURNER, Sean C ,  GASIECKI, Alan F ,  GRACIAS, Vijaya J ,  SARRIS, Kathy ,  KALVIN, Douglas M ,  MICHMERHUIZEN, Melissa J ,  SHUAI, Qi ,  PATEL, Jyoti R ,  BAKKER, Margaretha ,  TEUSCH, Nicole ,  JOHNSON, Eric F. ,  KOVAR, Peter J ,  DJURIC, Stevan W ,  LONG, Andrew J ,  VASUDEVAN, Anil ,  HOBSON, Adrian ,  ST. JOHN MOORE, Nigel ,  WANG, Lu ,  GEORGE, Dawn ,  LI, Biqin ,  FRANK, Kristine

IPC: C07D403/04 ,  C07D413/04 ,  C07D417/04

CPC classification number: C07D403/04 ,  C07D413/04 ,  C07D417/04

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R1, R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.