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    Multiple electrospray device, systems and methods
    1.
    发明专利
    Multiple electrospray device, systems and methods 未知

    公开(公告)号：AU2450801A

    公开(公告)日：2001-07-16

    申请号：AU2450801

    申请日：2000-12-22

    Applicant: ADVION BIOSCIENCES INC

    Inventor： SCHULTZ GARY A ,  CORSO THOMAS N ,  PROSSER SIMON J

    IPC: G01N27/62 ,  B05B5/08 ,  G01N21/33 ,  G01N21/53 ,  G01N21/64 ,  G01N27/00 ,  G01N27/447 ,  G01N30/88 ,  G01N37/00 ,  H01J49/04 ,  H01J49/10 ,  H01J49/26

    Abstract: A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device includes a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray. A method and system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analytes contained within the fluid. A plurality of electrospray nozzle devices can be used in the form of an array of miniaturized nozzles for the purpose of generating multiple electrospray plumes from multiple nozzles for the same fluid stream. This invention dramatically increases the sensitivity of microchip electrospray devices compared to prior disclosed systems and methods.

    ROBOTIC AUTOSAMPLER FOR AUTOMATED ELECTROSPRAY FROM A MICROFLUIDIC CHIP
    2.
    发明专利
    ROBOTIC AUTOSAMPLER FOR AUTOMATED ELECTROSPRAY FROM A MICROFLUIDIC CHIP 未知

    公开(公告)号：CA2434569A1

    公开(公告)日：2002-08-01

    申请号：CA2434569

    申请日：2002-01-28

    Applicant: ADVION BIOSCIENCES INC

    Inventor： PROSSER SIMON J ,  RULE GEOFFREY S ,  SCHULTZ GARY A ,  CORSO THOMAS N

    IPC: G01N27/62 ,  G01N1/00 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  B01D59/44 ,  H01J49/00

    Abstract: A robotic autosampler (1) provides for automated manipulation of microfluidi c chips having multiple electrospray devices and/or sample inlets (113) for interface to a mass spectrometer (111) or other detection device. The autosampler also provides for connection of control voltages to the electrospray device to facilitate enablement, control and steering of charge d droplets and ions. The autosampler further provides a method of fluid delive ry that may be disposable or reusable. The delivery device may contain material s for component separation or sample purification. The delivery device may contain preloaded sample or the sample may be loaded by the autosampler. A method for automated manipulation of multiple electrosprays (115) in communication with a detector, includes: providing a robot autosampler havin g an electrospray chip (80); electrospraying at least one analyte from at leas t one electrospray device on the electrospray chip; and manipulating the electrospray chip in communication with a detector in a manner to detect analyte from the electrospray.

    MULTIPLE ELECTROSPRAY DEVICE, SYSTEMS AND METHODS
    3.
    发明专利
    MULTIPLE ELECTROSPRAY DEVICE, SYSTEMS AND METHODS 未知

    公开(公告)号：CA2395694A1

    公开(公告)日：2001-07-12

    申请号：CA2395694

    申请日：2000-12-22

    Applicant: ADVION BIOSCIENCES INC

    Inventor： CORSO THOMAS N ,  PROSSER SIMON J ,  SCHULTZ GARY A

    IPC: G01N27/62 ,  B05B5/08 ,  G01N21/33 ,  G01N21/53 ,  G01N21/64 ,  G01N27/00 ,  G01N27/447 ,  G01N30/88 ,  G01N37/00 ,  H01J49/04 ,  H01J49/10 ,  H01J49/26

    Abstract: A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device (250) includes a substrate (200) defining a channel (224) between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle (232) defined b y a portion recessed from the ejection surface surrounding the exit orifice, a nd an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray (262). A method an d system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectromet er that is approximately proportional to the number of electrospray plumes form ed for analytes contained within the fluid. A plurality of electrospray nozzle devices (232) can be used in the form of an array of miniaturized nozzles fo r the purpose of generating multiple electrospray plumes (262) from multiple nozzles (232) for the same fluid stream. This invention dramatically increas es the sensitivity of microchip electrospray devices (250) compared to prior disclosed systems and methods.

    MULTIPLE ELECTROSPRAY DEVICE, SYSTEMS AND METHODS
    4.
    发明专利
    MULTIPLE ELECTROSPRAY DEVICE, SYSTEMS AND METHODS 未知

    公开(公告)号：CA2395694C

    公开(公告)日：2006-11-21

    申请号：CA2395694

    申请日：2000-12-22

    Applicant: ADVION BIOSCIENCES INC

    Inventor： CORSO THOMAS N ,  PROSSER SIMON J ,  SCHULTZ GARY A

    IPC: G01N27/62 ,  H01J49/04 ,  B05B5/08 ,  G01N21/33 ,  G01N21/53 ,  G01N21/64 ,  G01N27/00 ,  G01N27/447 ,  G01N30/88 ,  G01N37/00 ,  H01J49/10 ,  H01J49/26

    Abstract: A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device (250) includes a substrate (200) defining a channel (224) between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle (232) defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray (262). A method and system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analytes contained within the fluid. A plurality of electrospray nozzle devices (232) can be used in the form of an array of miniaturized nozzles for the purpose of generating multiple electrospray plumes (262) from multiple nozzles (232) for the same fluid stream. This invention dramatically increases the sensitivity of microchip electrospray devices (250) compared to prior disclosed systems and methods.

    Robotic autosampler for automated electrospray from a microfluidic chip
    5.
    发明专利
    Robotic autosampler for automated electrospray from a microfluidic chip 未知

    公开(公告)号：AU2002240143A1

    公开(公告)日：2002-08-06

    申请号：AU2002240143

    申请日：2002-01-28

    Applicant: ADVION BIOSCIENCES INC

    Inventor： SCHULTZ GARY A ,  CORSO THOMAS N ,  PROSSER SIMON J ,  RULE GEOFFREY S

    IPC: G01N27/62 ,  G01N1/00 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  B01D59/44 ,  H01J49/00

    Abstract: A robotic autosampler provides for automated manipulation of microfluidic chips having multiple electrospray devices and/or sample inlets for interface to a mass spectrometer or other detection device. The autosampler also provides for connection of control voltages to the electrospray device to facilitate enablement, control and steering of charged droplets and ions. The autosampler further provides a method of fluid delivery that may be disposable or reusable. The delivery device may contain materials for component separation or sample purification. The delivery device may contain preloaded sample or the sample may be loaded by the autosampler. A method for automated manipulation of multiple electrosprays in communication with a detector, includes: providing a robot autosampler having an electrospray chip; electrospraying at least one analyte from at least one electrospray device on the electrospray chip; and manipulating the electrospray chip in communication with a detector in a manner to detect analyte from the electrospray.

    ROBOTIC AUTOSAMPLER FOR AUTOMATED ELECTROSPRAY FROM A MICROFLUIDIC CHIP
    6.
    发明申请
    ROBOTIC AUTOSAMPLER FOR AUTOMATED ELECTROSPRAY FROM A MICROFLUIDIC CHIP 审中-公开
    用于微流控芯片的自动电动机的机动自动控制器

    公开(公告)号：WO02059563A3

    公开(公告)日：2002-09-26

    申请号：PCT/US0202467

    申请日：2002-01-28

    Applicant: ADVION BIOSCIENCES INC

    Inventor： PROSSER SIMON J ,  RULE GEOFFREY S ,  SCHULTZ GARY A ,  CORSO THOMAS N

    IPC: G01N27/62 ,  G01N1/00 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  B01D59/44 ,  H01J49/00

    CPC classification number: G01N35/10 ,  G01N35/0099 ,  G01N35/04 ,  G01N2035/00158 ,  G01N2035/0491 ,  G01N2035/1034 ,  H01J49/0413 ,  H01J49/165

    Abstract: A robotic autosampler (1) provides for automated manipulation of microfluidic chips having multiple electrospray devices and/or sample inlets (113) for interface to a mass spectrometer (111) or other detection device. The autosampler also provides for connection of control voltages to the electrospray device to facilitate enablement, control and steering of charged droplets and ions. The autosampler further provides a method of fluid delivery that may be disposable or reusable. The delivery device may contain materials for component separation or sample purification. The delivery device may contain preloaded sample or the sample may be loaded by the autosampler. A method for automated manipulation of multiple electrosprays (115) in communication with a detector, includes: providing a robot autosampler having an electrospray chip (80); electrospraying at least one analyte from at least one electrospray device on the electrospray chip; and manipulating the electrospray chip in communication with a detector in a manner to detect analyte from the electrospray.

    Abstract translation: 机器人自动进样器（1）提供具有多个电喷雾装置和/或样品入口（113）的微流体芯片的自动操作，用于与质谱仪（111）或其它检测装置的接口。 自动进样器还提供了将控制电压连接到电喷雾装置，以便于带电液滴和离子的启用，控制和转向。 自动进样器还提供可以是一次性的或可重复使用的流体输送方法。 输送装置可以含有用于组分分离或样品纯化的材料。 输送装置可以包含预加载的样品，或者样品可以由自动进样器装载。 一种用于与检测器通信的多个电喷雾（115）的自动操作的方法，包括：提供具有电喷雾芯片（80）的机器人自动进样器; 从电喷雾芯片上的至少一个电喷雾装置电喷雾至少一种分析物; 以及以检测来自电喷雾的分析物的方式操纵与检测器通信的电喷雾芯片。

    ROBOTIC AUTOSAMPLER FOR AUTOMATED ELECTROSPRAY FROM A MICROFLUIDIC CHIP
    8.
    发明公开
    ROBOTIC AUTOSAMPLER FOR AUTOMATED ELECTROSPRAY FROM A MICROFLUIDIC CHIP 审中-公开
    用于自动电的机器人自动取样装置喷射从一个微电子芯片的油液

    公开(公告)号：EP1383592A4

    公开(公告)日：2007-02-21

    申请号：EP02706034

    申请日：2002-01-28

    Applicant: ADVION BIOSCIENCES INC

    Inventor： PROSSER SIMON J ,  RULE GEOFFREY S ,  SCHULTZ GARY A ,  CORSO THOMAS N

    IPC: G01N27/62 ,  G01N1/00 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  B01D59/44 ,  H01J49/00

    CPC classification number: G01N35/10 ,  G01N35/0099 ,  G01N35/04 ,  G01N2035/00158 ,  G01N2035/0491 ,  G01N2035/1034 ,  H01J49/0413 ,  H01J49/165

    Abstract: A robotic autosampler (1) provides for automated manipulation of microfluidic chips having multiple electrospray devices and/or sample inlets (113) for interface to a mass spectrometer (111) or other detection device. The autosampler also provides for connection of control voltages to the electrospray device to facilitate enablement, control and steering of charged droplets and ions. The autosampler further provides a method of fluid delivery that may be disposable or reusable. The delivery device may contain materials for component separation or sample purification. The delivery device may contain preloaded sample or the sample may be loaded by the autosampler. A method for automated manipulation of multiple electrosprays (115) in communication with a detector, includes: providing a robot autosampler having an electrospray chip (80); electrospraying at least one analyte from at least one electrospray device on the electrospray chip; and manipulating the electrospray chip in communication with a detector in a manner to detect analyte from the electrospray.

    MULTIPLE ELECTROSPRAY DEVICE, SYSTEMS AND METHODS
    10.
    发明公开
    MULTIPLE ELECTROSPRAY DEVICE, SYSTEMS AND METHODS 有权
    多电喷涂设备，系统和方法

    公开(公告)号：EP1269518A4

    公开(公告)日：2006-06-28

    申请号：EP00988285

    申请日：2000-12-22

    Applicant: ADVION BIOSCIENCES INC

    Inventor： SCHULTZ GARY A ,  CORSO THOMAS N ,  PROSSER SIMON J

    IPC: G01N27/62 ,  B05B5/08 ,  G01N21/33 ,  G01N21/53 ,  G01N21/64 ,  G01N27/00 ,  G01N27/447 ,  G01N30/88 ,  G01N37/00 ,  H01J49/04 ,  H01J49/10 ,  H01J49/26

    CPC classification number: H01J49/167 ,  H01J49/0018 ,  H01J49/04

    Abstract: A microchip-based electrospray device, system, and method of fabrication thereof are disclosed. The electrospray device (250) includes a substrate (200) defining a channel (224) between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle (232) defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electric field generating source for application of an electric potential to the substrate to optimize and generate an electrospray (262). A method and system are disclosed to generate multiple electrospray plumes from a single fluid stream that provides an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analytes contained within the fluid. A plurality of electrospray nozzle devices (232) can be used in the form of an array of miniaturized nozzles for the purpose of generating multiple electrospray plumes (262) from multiple nozzles (232) for the same fluid stream . This invention dramatically increases the sensitivity of microchip electrospray devices (250) compared to prior disclosed systems and methods.

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