公开(公告)号：JP2006234838A

公开(公告)日：2006-09-07

申请号：JP2006127976

申请日：2006-05-01

Applicant: Advion Biosciences Inc ,  Kionix Inc ,  アドヴィオン バイオサイエンシィズ インコーポレイテッド ,  キオニックス インコーポレイテッド

Inventor： MOON JAMES E ,  SCHULTZ GARY A ,  CORSO THOMAS N ,  DAVIS TIMOTHY J ,  GALVIN GREGORY J ,  LOWES STEPHEN

IPC: G01N27/62 ,  B01D15/08 ,  G01N30/60 ,  G01N30/72 ,  G01N37/00 ,  H01J49/04

CPC classification number: G01N30/6095 ,  G01N30/7266 ,  G01N2030/6013 ,  H01J49/0018 ,  H01J49/167 ,  Y10T436/24 ,  Y10T436/2575

Abstract: PROBLEM TO BE SOLVED: To provide a chemical analytical system of large capacity easy to be reproduced and allowing mass production. SOLUTION: The chemical analytical system includes the first substrate having a main face, the second substrate joined or attached thereto, a liquid chromatography system integrated thereto, and constituted to receive and treat an analytical liquid to be discharged, and a monolithic electrospray device having an inlet orifice located in a injection side, a nozzle located on a discharge face opposite to the injection side, a channel extended penetrated continuously through a monolithic device, and communicated with the inlet orifice and the nozzle, and an area recessed from the discharge face to surround the nozzle. The monolithic device is integrated on the first substrate, the injection side is constituted to receive the treated liquid from the liquid chromatography system, and the main face is constituted to distribute the liquid by electrospraying the liquid. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供容易复制的大容量化学分析系统，并允许批量生产。 解决方案：化学分析系统包括具有主面，第二基板接合或附着的第一基板，与其一体化的液相色谱系统，构成为接收和处理要排出的分析液，以及单片电喷雾 装置，其具有位于注射侧的入口孔，位于与注射侧相对的排出面上的喷嘴，延伸穿过单片装置连续穿过并与入口孔和喷嘴连通的区域， 排出面以围绕喷嘴。 该单片装置集成在第一基板上，注射侧构成为从液相色谱系统接收经处理的液体，并且主面构成为通过电喷雾液体来分配液体。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2006234837A

公开(公告)日：2006-09-07

申请号：JP2006127975

申请日：2006-05-01

Applicant: Advion Biosciences Inc ,  Kionix Inc ,  アドヴィオン バイオサイエンシィズ インコーポレイテッド ,  キオニックス インコーポレイテッド

Inventor： MOON JAMES E ,  SCHULTZ GARY A ,  CORSO THOMAS N ,  DAVIS TIMOTHY J ,  GALVIN GREGORY J ,  LOWES STEPHEN

IPC: G01N27/62 ,  G01N30/60 ,  B01D15/08 ,  G01N30/72 ,  G01N37/00 ,  H01J49/04

CPC classification number: G01N30/6095 ,  G01N30/7266 ,  G01N2030/6013 ,  H01J49/0018 ,  H01J49/167 ,  Y10T436/24 ,  Y10T436/2575

Abstract: PROBLEM TO BE SOLVED: To provide a separator and a system for chemical separation of large capacity easy to be reproduced and allowing mass production. SOLUTION: The chemical separator includes a substrate for forming a channel, a plurality of columnar bodies worked of the substrate and extended from the channel, an electric insulation layer provided on a surface of the substrate, and an immobilization phase joined to the columnar bodies reacting with an analyzed sample introduced into the channel for the separation, and the analyzed sample is electrically insulated from the substrate. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供容易再现并允许批量生产的大容量化学分离分离器和系统。 解决方案：化学分离器包括用于形成通道的基板，从基板加工并从通道延伸的多个柱状体，设置在基板的表面上的电绝缘层，以及与基板接合的固定相 柱状体与引入通道的分析样品反应以进行分离，并且分析的样品与基底电绝缘。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：CA2363414C

公开(公告)日：2008-02-05

申请号：CA2363414

申请日：2000-02-29

Applicant: ADVION BIOSCIENCES INC

Inventor： CORSO THOMAS N ,  SCHULTZ GARY A ,  GALVIN GREGORY J ,  DAVIS TIMOTHY J ,  MOON JAMES E

IPC: B05B5/025 ,  B81C1/00 ,  G01N27/26 ,  G01N27/447 ,  G01N30/60 ,  G01N30/72 ,  H01J49/04 ,  H01J49/10

Abstract: A droplet/electrospray device and a liquid chromatography-electrospray system are disclosed. The droplet/electrospray device (100) comprises a substrate (102) defining a channel (104) between an entrance orifice (106) on an injection surface (108) and an exit orifice on an ejection surface (112), a nozzle (110) defined by a portion recessed from the ejection surface (112) surrounding the exit orifice, and an electrode (122) for application of an electric potential to the substrate (102) to optimize and generate droplets or an electrospray (62). A plurality of these electrospray devices (100) can be used in the fonn of an array of miniaturized nozzles. The liquid chromatography-electrospray device (160) comprises a separation substrate (162) defining an introduction channel (164) between an entrance orifice and a reservoir (166) and a separation channel (168) between the reservoir (166) and an exit orifice (170), the separation channel (168) being populated with separation posts (174) perpendicular to the fluid flow.

公开(公告)号：HK1066863A1

公开(公告)日：2005-04-01

申请号：HK04109844

申请日：2004-12-13

Applicant: ADVION BIOSCIENCES INC ,  KIONIX INC

Inventor： MOON JAMES E ,  SCHULTZ GARY A ,  CORSO THOMAS N ,  DAVIS TIMOTHY J ,  GALVIN GREGORY J ,  LOWES STEPHEN

IPC: G01N20060101 ,  B01D20060101 ,  G01N27/62 ,  B01D15/08 ,  G01N30/60 ,  G01N30/72 ,  G01N37/00 ,  H01J20060101 ,  H01J49/04

Abstract: An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

公开(公告)号：EP1163512A4

公开(公告)日：2007-08-08

申请号：EP00913655

申请日：2000-02-29

Applicant: ADVION BIOSCIENCES INC ,  KIONIX INC

Inventor： SCHULTZ GARY A ,  CORSO THOMAS N ,  MOON JAMES E ,  DAVIS TIMOTHY J ,  GALVIN GREGORY J

IPC: G01N30/60 ,  G01N30/72 ,  H01J49/04 ,  H01J49/10

CPC classification number: H01J49/167 ,  G01N30/6095 ,  G01N30/7266 ,  H01J49/0018

Abstract: A droplet/electrospray device and a liquid chromatography-electrospray system are disclosed. The droplet/electrospray device (100) comprises a substrate (102) defining a channel (104) between an entrance orifice (106) on an injection surface (108) and an exit orifice on an ejection surface (112), a nozzle (110) defined by a portion recessed from the ejection surface (112) surrounding the exit orifice, and an electrode (122) for application of an electric potential to the substrate (102) to optimize and generate droplets or an electrospray (62). A plurality of these electrospray devices (100) can be used in the form of an array of miniaturized nozzles. The liquid chromatography-electrospray device (160) comprises a separation substrate (162) defining an introduction channel (164) between an entrance orifice and a reservoir (166) and a separation channel (168) between the reservoir (166) and an exit orifice (170), the separation channel (168) being populated with separation posts (174) perpendicular to the fluid flow.

公开(公告)号：EP1113850A4

公开(公告)日：2006-02-01

申请号：EP99945401

申请日：1999-09-01

Applicant: ADVION BIOSCIENCES INC ,  KIONIX INC

Inventor： MOON JAMES E ,  SCHULTZ GARY A ,  CORSO THOMAS N ,  DAVIS TIMOTHY J ,  GALVIN GREGORY J ,  LOWES STEPHEN

IPC: G01N27/62 ,  B01D15/08 ,  G01N30/60 ,  G01N30/72 ,  G01N37/00 ,  H01J49/04

CPC classification number: G01N30/6095 ,  G01N30/7266 ,  G01N2030/6013 ,  H01J49/0018 ,  H01J49/167 ,  Y10T436/24 ,  Y10T436/2575