公开(公告)号：JPS6322803A

公开(公告)日：1988-01-30

申请号：JP31283586

申请日：1986-12-26

Applicant: AGENCY IND SCIENCE TECHN

Inventor： HIRANO TAKASHI ,  OHASHI SHINICHI ,  MORIMOTO SATOSHI ,  SHIRAKI MASARU ,  TSUDA KEISHIRO ,  KOBAYASHI TOMOO ,  TSUKAGOSHI SHIGERU

IPC: A61K31/765 ,  A61K45/00 ,  A61K47/48 ,  A61P35/00 ,  C08F8/30

Abstract: PURPOSE:To obtain a copolymer having excellent slow-releasing property of a carcinostatic substance, low toxicity and improved carcinostatic effect, by reacting a carcinostatic substance to a divinyl ether-maleic anhydride copolymer and hydrolyzing the reaction product. CONSTITUTION:A divinyl ether-maleic anhydride copolymer of formula I (n is a value corresponding to the copolymer molecular weight of 2,000-15,000) is made to react with a carcinostatic substance having hydroxyl group or amino group (e.g. 5-fluorouridine, 1-beta-D-arabinofuranosylcytosine) in the presence of an organic solvent (e.g. N-methylpyrrolidone) at a rate to give a content of usually 5-40wt%. The reaction product is hydrolyzed and optionally converted to a salt to obtain the objective copolymer of formula II (R is residue obtained by removing one H atom from the hydroxyl group or amino group of the above carcinostatic substance). EFFECT:The carcinostatic activity is promoted by the synergistic effect with the carcinostatic activity of the copolymer.