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    2.
    发明专利
    未知

    公开(公告)号：DE19929734B4

    公开(公告)日：2005-10-06

    申请号：DE19929734

    申请日：1999-06-29

    Applicant: AGILENT TECHNOLOGIES INC

    Inventor： ROBOTTI KARLA M ,  SWEDBERG SALLY A ,  YIN HONGFENG

    IPC: B01J19/00 ,  B01L3/00 ,  B81B1/00 ,  B81B3/00 ,  F15C5/00 ,  F16K99/00 ,  B01L11/00

    Abstract: Micro-fluid devices and methods for their use are provided. The subject devices are characterized by the presence of at least one micro-valve comprising a phase reversible material, e.g. a reversible gel, that reversibly changes its physical state in response to an applied stimulus, e.g. a thermoreversible gel. In using the subject device, fluid flow along a flow path of the device is modulated by applying an appropriate stimulus, e.g. changing the temperature, to the microvalve. The subject devices find use in a variety of applications, including micro-analytical applications.

    4.
    发明专利
    未知

    公开(公告)号：DE69940138D1

    公开(公告)日：2009-02-05

    申请号：DE69940138

    申请日：1999-06-14

    Applicant: AGILENT TECHNOLOGIES INC

    Inventor： YIN HONGFENG ,  CHAKEL JOHN A ,  SWEDBERG SALLY A

    IPC: H01J49/04 ,  G01N30/72

    Abstract: A miniaturized planar device is described for use in a liquid phase analysis system. The device comprises a separation compartment that is in fluidic communication with a make-up flow channel and a channel compartment that terminates in a on-device mass spectrometer delivery means. The device is formed by microfabrication of microstructures in novel support substrates. The invention herein is used for the analysis of small and/or macromolecular and/or other solutes in the liquid phase.

    5.
    发明专利
    未知

    公开(公告)号：DE19952764C2

    公开(公告)日：2003-02-27

    申请号：DE19952764

    申请日：1999-11-02

    Applicant: AGILENT TECHNOLOGIES INC

    Inventor： SWEDBERG SALLY A ,  BRENNEN REID A

    IPC: B01L3/00 ,  G01N35/08 ,  B01J19/00 ,  B81B7/00

    Abstract: A microanalysis device having a plurality of sample processing compartments is described for use in liquid phase analysis. A microanalysis device system, comprising a plurality of interconnected microanalysis devices. The device is formed by microfabrication of microstructures in novel support substrates. The invention herein can be used for the analysis of small and/or macromolecular and/or other solutes in the liquid phase.

    6.
    发明专利
    未知

    公开(公告)号：DE19926114B4

    公开(公告)日：2006-06-29

    申请号：DE19926114

    申请日：1999-06-08

    Applicant: AGILENT TECHNOLOGIES INC

    Inventor： SWEDBERG SALLY A ,  ROBOTTI KARLA M ,  CALDWELL KARIN

    IPC: C08J7/04 ,  B01D57/02 ,  B05D7/02 ,  C08G65/329 ,  C08G65/333 ,  C08G65/334 ,  C08L71/02 ,  C09D171/02 ,  C25D13/22

    Abstract: Methods and compositions for modifying the surface of a polymeric substrate are provided. In the subject methods, at least a portion of the surface of the polymeric substrate is contacted with a biofouling resistant surfactant composition. At least a portion of the surfactant molecules of the composition are end modified with a non-reactive, charged end group that is charge stable over a pH range of about 2 to 12. The subject methods and compositions find particular use with electrophoretic devices, such as capillary electrophoretic devices.

    7.
    发明专利
    未知

    公开(公告)号：DE69532741T2

    公开(公告)日：2005-01-20

    申请号：DE69532741

    申请日：1995-10-19

    Applicant: AGILENT TECHNOLOGIES INC

    Inventor： WITT KLAUS E ,  KALTENBACH PATRICK ,  BEK FRITZ ,  SWEDBERG SALLY A ,  MITTELSTADT LAURIE S

    IPC: B01L3/00 ,  B01L3/02 ,  B01L7/00 ,  B29C65/02 ,  B81B1/00 ,  B81C1/00 ,  G01N27/447 ,  G01N30/02 ,  G01N30/28 ,  G01N30/30 ,  G01N30/60

    Abstract: A miniaturized total analysis system (" mu -TAS") (200) comprising a miniaturized planar column device (2) is described for use in liquid phase analysis. The mu -TAS (200) comprises microstructures fabricated by laser ablation in a variety of novel support substrates (4). The mu -TAS (200) includes associated laser-ablated features (10) required for integrated sample analysis, such as analyte detection means and fluid communication means. mu -TAS (200) constructed according to the invention is useful in any analysis system for detecting and analyzing small and/or macromolecular solutes in the liquid phase and may employ chromatographic separation means, electrophoretic separation means, electrochromatographic separation means, or combinations thereof.

    Microreactor for performing polymerase chain reactions, requires only very small sample and is made of material stable during temperature cycling
    8.
    发明专利
    Microreactor for performing polymerase chain reactions, requires only very small sample and is made of material stable during temperature cycling 未知

    公开(公告)号：DE10106008A1

    公开(公告)日：2001-09-06

    申请号：DE10106008

    申请日：2001-02-09

    Applicant: AGILENT TECHNOLOGIES INC

    Inventor： TSO JACQUELINE ,  SWEDBERG SALLY A ,  WEBBER PAUL K

    IPC: B01L3/00 ,  B01L7/00 ,  B81B1/00 ,  B81C1/00 ,  G01N27/447 ,  G01N30/02 ,  G01N30/28 ,  G01N30/60 ,  C12M1/38 ,  C12M1/36

    Abstract: Apparatus for performing polymerase chain reaction (PCR) includes a reaction chamber, designed to hold 1-500 micro l of fluid, and is made of a material (A) that is thermally, chemically and mechanically stable under PCR conditions. Apparatus for performing polymerase chain reaction (PCR) includes a reaction chamber, designed to hold 1-500 micro l of fluid, and is made of a material (A) that is thermally, chemically and mechanically stable under PCR conditions. It comprises the chamber, defined by at least two internal surfaces; device for introducing PCR components into the chamber; device for removing PCR products from the chamber and device for controlling temperature in the chamber. Independent claims are also included for the following: (a) microreactor for amplifying DNA by PCR including a substrate (33) and covering plate (43) that, under PCR conditions, are stable and resist biological growth; (b) method for performing PCR, to amplify DNA in a sample, using a microreactor made of (A) and having one or more reaction chambers that hold 1-500 micro l of fluid; and (c) method for amplifying the amount of a specific DNA present in a small volume of sample fluid.

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