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公开(公告)号：JP2013181532A
公开(公告)日：2013-09-12
申请号：JP2013011279
申请日：2013-01-24
Inventor： KILLEEN KEVIN P , BRENNEN REID A , CHANG DUSTIN , HOEN STORRS T
CPC classification number: F04B43/046 , F04B19/006
Abstract: PROBLEM TO BE SOLVED: To provide a piezoelectric actuator that is easily manufactured and less contaminated when various fluids are used.SOLUTION: A fluid pumping device (300) includes micro fluid devices (301-303) and piezoelectric actuators (311-313) externally coupled to the microfluidic devices. The piezoelectric actuator has an axial displacement along a lengthwise axis responsive to application of a bias voltage. The axial displacement of the piezoelectric actuator operates internal valves (346, 348) or an internal pump chamber (342) of the micro fluid device.
Abstract translation: 要解决的问题：提供一种在使用各种流体时容易制造和较少污染的压电致动器。解决方案：流体泵送装置（300）包括外部的微流体装置（301-303）和压电致动器（311-313） 耦合到微流体装置。 响应于施加偏置电压，压电致动器沿纵轴具有轴向位移。 压电致动器的轴向位移操作微流体装置的内部阀（346,348）或内部泵室（342）。
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公开(公告)号：DE10001664A1
公开(公告)日：2000-07-27
申请号：DE10001664
申请日：2000-01-17
Applicant: AGILENT TECHNOLOGIES INC
Inventor： BRENNEN REID A , SWEDBERG SALLY A
Abstract: Substrate surface texturing, by material removal and/or addition to form a high surface area texturing, is new. Independent claims are also included for the following: (1) a high surface area textured substrate produced by the novel process; (2) a miniature analysis device produced by the novel process; and (3) production of a duplicated copy of a high surface area textured substrate using the substrate of (1) or the device of (2) as the original.
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公开(公告)号：WO2015047598A2
公开(公告)日：2015-04-02
申请号：PCT/US2014051708
申请日：2014-08-19
Applicant: AGILENT TECHNOLOGIES INC , YIN HONGFENG , BRENNEN REID A , LYSTER ERIC , SLOCUM ROGER
Inventor： YIN HONGFENG , BRENNEN REID A , LYSTER ERIC , SLOCUM ROGER
IPC: G01N30/26
CPC classification number: G01N30/606 , G01N30/6065 , G01N30/6086
Abstract: A liquid chromatography (LC) column includes a wall having a length along a central axis from the inlet end to the outlet end, the wall enclosing a column interior and having a column radius relative to the central axis, the wall comprising a structured portion configured such that the column radius varies along the length; and a plurality of particles packed in the column interior, wherein at least some of the particles are in contact with the structured portion.
Abstract translation: 液相色谱（LC）柱包括壁，该壁具有从入口端到出口端的中心轴线的长度，所述壁围绕柱内部并具有相对于中心轴线的柱半径，所述壁包括构造的结构部分 使得柱半径沿长度变化; 以及填充在塔内部的多个颗粒，其中至少一些颗粒与结构化部分接触。
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公开(公告)号：DE10154601A1
公开(公告)日：2002-06-13
申请号：DE10154601
申请日：2001-11-07
Applicant: AGILENT TECHNOLOGIES INC
Inventor： BRENNEN REID A , YIN HONGFENG , KILLEEN KEVIN P
Abstract: A micro-component (10) comprises a substrate (12) having a planar surface (14) and a micro-channel (18); a covering plate (30) on the planar surface; an electro-spraying emitter forming a section of the substrate and/or the covering plate; and a sample inlet gate in fluid communication with a line and allowing a fluid sample to be conveyed from an external source in a defined sample path. Independent claims are also included for the following: (i) the production of the micro-component; and (ii) for the ionization of a fluid sample in a spraying chamber using the micro-component. Preferred Features: The emitter has a concave or planar end surface arranged next to the sample outlet gate.
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公开(公告)号：DE102013201330A1
公开(公告)日：2013-08-29
申请号：DE102013201330
申请日：2013-01-28
Applicant: AGILENT TECHNOLOGIES INC
Inventor： KILLEEN KEVIN P , BRENNEN REID A , CHANG DUSTIN , HOEN STORRS T
IPC: F04B43/04
Abstract: Fluidpumpvorrichtung (100, 200) enthaltend einen piezoelektrischen Aktor (110), welcher extern gekoppelt ist mit einer mikrofluidischen Vorrichtung (130, 230). Der piezoelektrische Aktor hat eine axiale Auslenkung entlang einer längsgerichteten Achse in Reaktion auf ein Anlegen einer Biasspannung. Die axiale Auslenkung des piezoelektrischen Aktors betreibt eines von einem internen Ventil (240, 245) und einer internen Pumpenkammer (140) der mikrofluidischen Vorrichtung.
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Patent Agency Ranking
公开(公告)号：GB2446254B
公开(公告)日：2011-09-07
申请号：GB0800269
申请日：2008-01-08
Applicant: AGILENT TECHNOLOGIES INC
Inventor： BEERLING TIMOTHY , KRAICZEK KARSTEN G , BRENNEN REID A
Abstract: In some embodiments of the present invention, the buried silicon oxide technology is employed in the fabrication of fluid channels, particularly nanochannels. For example, a fluid channel can be made in a buried silicon oxide layer by etching the buried oxide layer with a method that selectively removes silicon oxide but not silicon. Thus, one dimension of the resulting fluid channel is limited by the thickness of the buried oxide layer. It is possible to manufacture a very thin buried oxide layer with great precision, thus a nanochannel can be fabricated in a controlled manner. Moreover, in addition to buried oxide, any pairs of substances with a high etch ratio with respect to each other can be used in the same way. Further provided are the fluid channels, apparatuses, devices and systems comprising the fluid channels, and uses thereof.
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公开(公告)号：DE10309583B4
公开(公告)日：2005-12-08
申请号：DE10309583
申请日：2003-03-05
Applicant: AGILENT TECHNOLOGIES INC
Inventor： BRENNEN REID A , KILLEEN KEVIN PATRICK , YIN HONGFENG
IPC: B01L3/00 , B01L3/02 , G01N30/46 , G01N30/60 , G01N30/72 , B01J19/00 , G01N27/62 , H01J49/00 , B81B1/00
Abstract: A microanalytical device is provided for conducting multiple chemical and/or biochemical reactions and analyzing multiple sample fluids in parallel using minute volumes of reaction or sample fluid. The devices comprises a well plate with an integrated microfluidic system containing processing compartments such as microcavities, microchannels and the like, that are in fluid communication with electrospray emitters. The novel microanalytical device can be used in a variety of chemical and biochemical contexts, including mass spectroscopy, chromatographic, electrophoretic and electrochromatographic separations, screening and diagnostics, and chemical and biochemical synthesis. The devices may be formed from a material that is thermally and chemically stable and resistant to biofouling, significantly reducing electroosmotic flow and unwanted adsorption of solute.
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公开(公告)号：DE10122133B4
公开(公告)日：2004-01-08
申请号：DE10122133
申请日：2001-05-08
Applicant: AGILENT TECHNOLOGIES INC
Inventor： BRENNEN REID A , GOOR ANTONIUS A A M VAN DE
IPC: B01L3/00 , B81B1/00 , B81B7/02 , G01N27/447 , G01N35/08 , B01J19/00 , G01N27/00 , G01N1/00 , G01N33/00
Abstract: A microfluidic component having a microfluidic channel is bonded to an electronics component having a circuit for processing signals related to the microfluidic component. In an embodiment, the electronics component is a prefabricated integrated circuit chip that includes signal processing and/or process control functionality. The bonding of the microfluidic component to the electronics component provides a modular architecture in which different combinations of microfluidic components and electronics components can be used to create customized processing and analysis tools.
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公开(公告)号：DE102008005350B4
公开(公告)日：2012-03-08
申请号：DE102008005350
申请日：2008-01-21
Applicant: AGILENT TECHNOLOGIES INC
Inventor： BEERLING TIMOTHY , KRAICZEK KARSTEN G , BRENNEN REID A
Abstract: Verfahren zum Herstellen einer mikrofluidischen Vorrichtung mit einem Kanal, der eine Dickenabmessung aufweist, wobei das Verfahren folgende Schritte umfasst: – Bereitstellen einer Halbleiterstruktur mit einem unter einer Siliziumschicht (102) angeordneten vergrabenen Siliziumoxidabschnitt (10schnitts die Dickenabmessung des zu erzeugenden Kanals festlegt; – Erzeugen einer Mehrzahl von Durchgangsöffnungen (108) durch die Siliziumschicht (102), wobei die Durchgangsöffnungen (108) in Richtung der Längserstreckung des zu erzeugenden Kanals beabstandet sind; und – Ätzen des Siliziumoxids des vergrabenen Siliziumoxidabschnittes, wobei die Siliziumschicht (102) als ein Ätzstopp dient, wodurch sich von den Durchgangsöffnungen (108) ausbreitende Ätzfronten zu dem Kanal vereinigen.
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公开(公告)号：DE102008005350A1
公开(公告)日：2008-08-07
申请号：DE102008005350
申请日：2008-01-21
Applicant: AGILENT TECHNOLOGIES INC
Inventor： BEERLING TIMOTHY , KRAICZEK KARSTEN G , BRENNEN REID A
Abstract: In some embodiments of the present invention, the buried silicon oxide technology is employed in the fabrication of fluid channels, particularly nanochannels. For example, a fluid channel can be made in a buried silicon oxide layer by etching the buried oxide layer with a method that selectively removes silicon oxide but not silicon. Thus, one dimension of the resulting fluid channel is limited by the thickness of the buried oxide layer. It is possible to manufacture a very thin buried oxide layer with great precision, thus a nanochannel can be fabricated in a controlled manner. Moreover, in addition to buried oxide, any pairs of substances with a high etch ratio with respect to each other can be used in the same way. Further provided are the fluid channels, apparatuses, devices and systems comprising the fluid channels, and uses thereof.
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