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1.发明申请THE USE OF A SUBSTANCE P ANTAGONIST FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF OCULAR PAIN 审中-公开用于制造治疗眼部疼痛的药物的物质拮抗剂的使用
公开(公告)号：WO1998014193A1
公开(公告)日：1998-04-09
申请号：PCT/US1997006410
申请日：1997-04-17
Applicant: ALCON LABORATORIES, INC.
Inventor： ALCON LABORATORIES, INC. , GAMACHE, Daniel, A. , YANNI, John, M.
IPC: A61K31/445
CPC classification number: A61K31/445
Abstract: Methods and compositions for treating ocular pain using a substance P antagonist are disclosed.
Abstract translation: 公开了使用物质P拮抗剂治疗眼痛的方法和组合物。
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2.发明申请COMPOSITIONS CONTAINING HYDROPEROXYEICOSATETRAENOIC ACID DERIVATIVES AND METHODS OF USE IN TREATING DRY EYE DISORDERS 审中-公开含有羟基异柠檬酸酯衍生物的组合物及其用于治疗干眼症的方法
公开(公告)号：WO1997016179A1
公开(公告)日：1997-05-09
申请号：PCT/US1996013441
申请日：1996-08-19
Applicant: ALCON LABORATORIES, INC.
Inventor： ALCON LABORATORIES, INC. , YANNI, John, M. , GAMACHE, Daniel, A. , MILLER, Steven, T.
IPC: A61K31/20
CPC classification number: A61K31/202 , Y10S514/912
Abstract: Compositions containing an HETE derivative and methods of use for treating dry eye are disclosed.
Abstract translation: 公开了含有HETE衍生物的组合物和用于治疗干眼症的方法。
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3.发明授权USE OF 11-(3-DIMETHYLAMINOPROPYLIDENE)-6,11-DIHYDRODIBENZ[B,E]OXEPIN-2-ACETIC ACID AND OF PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF NON-ALLERGIC OPHTHALMIC INFLAMMATORY DISORDERS AND FOR THE PREVENTION OF OCULAR NEOVASCULARIZATION 有权使用11-（3-二甲基氨基）-6,11-二氢苯并[b，E]制备用于治疗药物恶庚英-2-乙酸及其可药用盐非过敏相关的眼部炎症及眼部新生血管形成的预防
公开(公告)号：EP1037627B1
公开(公告)日：2001-08-01
申请号：EP99928600.8
申请日：1999-06-15
Applicant: Alcon Laboratories, Inc.
Inventor： YANNI, John, M. , GAMACHE, Daniel, A. , WEIMER, Lori, K.
IPC: A61K31/335
CPC classification number: A61K31/00
Abstract: Ophthalmic formulations containing as an active ingredient 11-(3-dimethylaminopropylidene) -6,11-dihydrodibenz[b,e]oxepin-2-acetic acid or a pharmaceutically acceptable salt thereof are useful for inhibiting cytokine release (e.g., IL-6 and IL-8) from human ocular cells. Such formulations can be used to treat or prevent ocular neovascularization and non-allergic inflammatory disorders such as dry-eye, keratitis, blepharitis, uveitis and inflammation related to infection.
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公开(公告)号：EP0946157B1
公开(公告)日：2002-03-13
申请号：EP97954571.2
申请日：1997-12-11
Applicant: ALCON LABORATORIES, INC.
Inventor： GAMACHE, Daniel, A.
IPC: A61K31/00
CPC classification number: A61K31/5513 , A61K31/00 , A61K31/137 , A61K31/40 , A61K31/402 , A61K31/407 , A61K31/438 , A61K31/439 , A61K31/485 , A61K31/496 , A61K31/541 , A61K31/5415 , A61K31/55 , Y10S514/912
Abstract: Compositions and methods for treating ocular pain are disclosed. In particular, the invention discloses compositions and methods of using kappa opioid agonists topically for the prevention or alleviation of ocular pain.
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5.发明授权COMPOSITIONS CONTAINING HYDROPEROXYEICOSATETRAENOIC ACID DERIVATIVES AND METHODS OF USE IN TREATING DRY EYE DISORDERS 失效HYDROPEROXEICOSATETRAENSÄURE衍生物含有使用组合物和方法干眼症的治疗
公开(公告)号：EP0858330B1
公开(公告)日：2000-12-13
申请号：EP96928944.6
申请日：1996-08-19
Applicant: ALCON LABORATORIES, INC.
Inventor： YANNI, John, M. , GAMACHE, Daniel, A. , MILLER, Steven, T.
IPC: A61K31/20
CPC classification number: A61K31/202 , Y10S514/912
Abstract: Compositions containing an HETE derivative and methods of use for treating dry eye are disclosed.
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Patent Agency Ranking6.发明公开
公开(公告)号：EP0799219A2
公开(公告)日：1997-10-08
申请号：EP95944517.0
申请日：1995-12-21
Applicant: ALCON LABORATORIES, INC.
Inventor： HELLBERG, Mark , GRAFF, Gustav , GAMACHE, Daniel, A. , NIXON, Jon, C. , GARNER, William, H.
CPC classification number: A61K31/343 , A61K31/353 , A61K31/355 , A61K47/545 , C07C235/34 , C07D307/80 , C07D311/72
Abstract: The compounds of the present invention are of the formula (I): A-X-(CH2)n-Y-(CH3)m-Z wherein: A is an non-steroidal anti-inflammatory agent (NSAIA); A-X is an ester or amide linkage derived from the carboxylic acid moiety of the NSAIA, wherein X is O or NR; R is H, C1-C6 alkyl or C3-C6 cycloalkyl; Y, if present, is O, NR, C(R)2, CH(OH) or S(O)n'; n is 2 to 4 and m is 1 to 4 when Y is O, NR, or S(O)n'; n is 0 to 4 and m is 0 to 4 when Y is C(R)2 or is not present; n is 1 to 4 and m is 0 to 4 when Y is CH(OH); n' is 0 to 2; and Z is (a), (b), (c), (d) or (e) wherein: R' and R3 are H, C(O)R, C(O)N(R)¿2, PO3?-, or SO¿3?-; R' is H or C¿1?-C6 alkyl; and R' and R?3¿ together may form a ring having structure: (1) or (2); and provided that when Z is (e), X is not O. The compounds of the present invention also include pharmaceutically acceptable salts of the compounds of formula (I). Methods for treating inflammatory pathologies are disclosed. Particularly, the methods utilize pharmaceutical compositions containing certain compounds having an anti-inflammatory and anti-oxidant moiety covalently linked by an amide or ester bond. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms.
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7.发明授权
公开(公告)号：EP0799219B1
公开(公告)日：2003-05-07
申请号：EP95944517.2
申请日：1995-12-21
Applicant: ALCON LABORATORIES, INC.
Inventor： HELLBERG, Mark , GRAFF, Gustav , GAMACHE, Daniel, A. , NIXON, Jon, C. , GARNER, William, H.
IPC: C07D311/72 , A61K31/355 , C07D307/80 , A61K31/34 , C07C235/34 , A61K31/16 , C07D317/60 , A61K31/36
CPC classification number: A61K31/343 , A61K31/353 , A61K31/355 , A61K47/545 , C07C235/34 , C07D307/80 , C07D311/72
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8.发明公开USE OF 11-(3-DIMETHYLAMINOPROPYLIDENE)-6,11-DIHYDRODIBENZ[B,E]OXEPIN-2-ACETIC ACID AND OF PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF NON-ALLERGIC OPHTHALMIC INFLAMMATORY DISORDERS AND FOR THE PREVENTION OF OCULAR NEOVASCULARIZATION 有权使用11-（3-二甲基氨基）-6,11-二氢苯并[b，E]制备用于治疗药物恶庚英-2-乙酸及其可药用盐非过敏相关的眼部炎症及眼部新生血管形成的预防
公开(公告)号：EP1037627A1
公开(公告)日：2000-09-27
申请号：EP99928600.8
申请日：1999-06-15
Applicant: Alcon Laboratories, Inc.
Inventor： YANNI, John, M. , GAMACHE, Daniel, A. , WEIMER, Lori, K.
IPC: A61K31/335
CPC classification number: A61K31/00
Abstract: Ophthalmic formulations containing as an active ingredient 11-(3-dimethylaminopropylidene) -6,11-dihydrodibenz[b,e]oxepin-2-acetic acid or a pharmaceutically acceptable salt thereof are useful for inhibiting cytokine release (e.g., IL-6 and IL-8) from human ocular cells. Such formulations can be used to treat or prevent ocular neovascularization and non-allergic inflammatory disorders such as dry-eye, keratitis, blepharitis, uveitis and inflammation related to infection.
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公开(公告)号：EP0946157A2
公开(公告)日：1999-10-06
申请号：EP97954571.0
申请日：1997-12-11
Applicant: ALCON LABORATORIES, INC.
Inventor： GAMACHE, Daniel, A.
CPC classification number: A61K31/5513 , A61K31/00 , A61K31/137 , A61K31/40 , A61K31/402 , A61K31/407 , A61K31/438 , A61K31/439 , A61K31/485 , A61K31/496 , A61K31/541 , A61K31/5415 , A61K31/55 , Y10S514/912
Abstract: Compositions and methods for treating ocular pain are disclosed. In particular, the invention discloses compositions and methods of using kappa opioid agonists topically for the prevention or alleviation of ocular pain.
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10.发明公开COMPOSITIONS CONTAINING HYDROPEROXYEICOSATETRAENOIC ACID DERIVATIVES AND METHODS OF USE IN TREATING DRY EYE DISORDERS 失效HYDROPEROXEICOSATETRAENSÄURE衍生物含有使用组合物和方法干眼症的治疗
公开(公告)号：EP0858330A1
公开(公告)日：1998-08-19
申请号：EP96928944.0
申请日：1996-08-19
Applicant: ALCON LABORATORIES, INC.
Inventor： YANNI, John, M. , GAMACHE, Daniel, A. , MILLER, Steven, T.
CPC classification number: A61K31/202 , Y10S514/912
Abstract: Compositions containing an HETE derivative and methods of use for treating dry eye are disclosed.
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