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1.发明申请TOPICALLY ADMINISTRABLE COMPOSITIONS CONTAINING 3-BENZOYLPHENYLACETIC ACID DERIVATIVES FOR TREATMENT OF OPHTHALMIC INFLAMMATORY DISORDERS 审中-公开含有3-苯甲酰基苯甲酸衍生物的主要管理组合物用于治疗眼底炎症性疾病
公开(公告)号：WO1995033457A1
公开(公告)日：1995-12-14
申请号：PCT/US1995007187
申请日：1995-06-06
Applicant: ALCON LABORATORIES, INC.
Inventor： ALCON LABORATORIES, INC. , YANNI, John, M. , GRAFF, Gustav , HELLBERG, Mark, R.
IPC: A61K31/165
CPC classification number: C07C237/20 , A61K31/165 , A61K31/215 , C07C233/33 , C07C323/60
Abstract: Novel ester and amide derivatives of 3-benzoylphenylacetic acid are disclosed. The use of these novel derivatives and certain known derivatives in topically administrable compositions for the treatment of ophthalmic inflammatory disorders is also disclosed.
Abstract translation: 公开了3-苯甲酰基苯乙酸的新型酯和酰胺衍生物。 还公开了这些新型衍生物和某些已知衍生物在局部给药组合物中用于治疗眼部炎症性疾病的用途。
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2.发明授权
公开(公告)号：EP0716600B1
公开(公告)日：2002-04-03
申请号：EP95923733.0
申请日：1995-06-06
Applicant: ALCON LABORATORIES, INC.
Inventor： YANNI, John, M. , GRAFF, Gustav , HELLBERG, Mark, R.
IPC: A61K31/165 , A61P27/02 , A61P29/00
CPC classification number: C07C237/20 , A61K31/165 , A61K31/215 , C07C233/33 , C07C323/60
Abstract: Novel ester and amide derivatives of 3-benzoylphenylacetic acid are disclosed. The use of these novel derivatives and certain known derivatives in topically administrable compositions for the treatment of ophthalmic inflammatory disorders is also disclosed.
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3.发明公开TOPICAL OPHTHALMIC MAST CELL STABILIZERS FOR TREATING ALLERGIC EYE DISEASES 有权方法确定与测定及其表面活动分类的浓度两性ANTIHISTAIMINISCHEN CONNECTION
公开(公告)号：EP1187617A2
公开(公告)日：2002-03-20
申请号：EP00917998.7
申请日：2000-03-16
Applicant: Alcon Laboratories, Inc.
Inventor： GRAFF, Gustav , YANNI, John M.
CPC classification number: A61K31/55 , A61K31/41 , Y10S514/912
Abstract: Topical ophthalmic anti-allergy drugs are identified by the extent of their interaction with a phospholipid model membrane. Disclosed are topically administrable ophthalmic formulations containing amphipathic anti-allergy compounds at concentrations such that the drugs have Surface Activity Ratings from about 2-11. Provided the drug is not selected from the group consisting of olopatadine; ketotifen; emedastine; pheniramine; pyrilamine; cromolyn; nedocromil; and levocabastine.
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公开(公告)号：EP0946171A1
公开(公告)日：1999-10-06
申请号：EP97951623.0
申请日：1997-12-16
Applicant: ALCON LABORATORIES, INC.
Inventor： YANNI, John, M. , GRAFF, Gustav
CPC classification number: C07C235/34 , A61K31/343 , A61K31/353 , A61K31/355 , A61K47/545 , C07D307/80 , C07D311/72 , Y10S514/912
Abstract: Compounds and methods for treating ocular tissues are disclosed. The methods utilize viscoelastic compositions containing certain compounds having an anti-inflammatory and anti-oxidant moiety covalently linked by an amide or ester bond. The compounds are useful in preventing and treating inflammatory and proliferative disorders through several mechanisms.
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Patent Agency Ranking5.发明公开
公开(公告)号：EP0799219A2
公开(公告)日：1997-10-08
申请号：EP95944517.0
申请日：1995-12-21
Applicant: ALCON LABORATORIES, INC.
Inventor： HELLBERG, Mark , GRAFF, Gustav , GAMACHE, Daniel, A. , NIXON, Jon, C. , GARNER, William, H.
CPC classification number: A61K31/343 , A61K31/353 , A61K31/355 , A61K47/545 , C07C235/34 , C07D307/80 , C07D311/72
Abstract: The compounds of the present invention are of the formula (I): A-X-(CH2)n-Y-(CH3)m-Z wherein: A is an non-steroidal anti-inflammatory agent (NSAIA); A-X is an ester or amide linkage derived from the carboxylic acid moiety of the NSAIA, wherein X is O or NR; R is H, C1-C6 alkyl or C3-C6 cycloalkyl; Y, if present, is O, NR, C(R)2, CH(OH) or S(O)n'; n is 2 to 4 and m is 1 to 4 when Y is O, NR, or S(O)n'; n is 0 to 4 and m is 0 to 4 when Y is C(R)2 or is not present; n is 1 to 4 and m is 0 to 4 when Y is CH(OH); n' is 0 to 2; and Z is (a), (b), (c), (d) or (e) wherein: R' and R3 are H, C(O)R, C(O)N(R)¿2, PO3?-, or SO¿3?-; R' is H or C¿1?-C6 alkyl; and R' and R?3¿ together may form a ring having structure: (1) or (2); and provided that when Z is (e), X is not O. The compounds of the present invention also include pharmaceutically acceptable salts of the compounds of formula (I). Methods for treating inflammatory pathologies are disclosed. Particularly, the methods utilize pharmaceutical compositions containing certain compounds having an anti-inflammatory and anti-oxidant moiety covalently linked by an amide or ester bond. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms.
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6.发明公开TOPICALLY ADMINISTRABLE COMPOSITIONS CONTAINING 3-BENZOYLPHENYLACETIC ACID DERIVATIVES FOR TREATMENT OF OPHTHALMIC INFLAMMATORY DISORDERS 失效3-BENZOYLPHENNYLESSIGSÄURE衍生物含局部组合物用于治疗眼科炎性疾病
公开(公告)号：EP0716600A1
公开(公告)日：1996-06-19
申请号：EP95923733.0
申请日：1995-06-06
Applicant: ALCON LABORATORIES, INC.
Inventor： YANNI, John, M. , GRAFF, Gustav , HELLBERG, Mark, R.
CPC classification number: C07C237/20 , A61K31/165 , A61K31/215 , C07C233/33 , C07C323/60
Abstract: Novel ester and amide derivatives of 3-benzoylphenylacetic acid are disclosed. The use of these novel derivatives and certain known derivatives in topically administrable compositions for the treatment of ophthalmic inflammatory disorders is also disclosed.
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公开(公告)号：EP0914169B1
公开(公告)日：2003-07-30
申请号：EP98925025.3
申请日：1998-05-29
Applicant: ALCON LABORATORIES, INC.
Inventor： GRAFF, Gustav , KARAKELLE, Mutlu , SHEETS, John, W., Jr. , YANNI, John, M.
IPC: A61L31/04
CPC classification number: A61L31/048 , Y10S623/901 , C08L33/04
Abstract: Improved glaucoma filtration device materials comprise at least one monomer having formula (I) wherein X is H or CH3; m is 0-10; Y is nothing, O, or S; R is nothing, H, or an aliphatic, aromatic or aliphatic/aromatic combination of up to twelve carbon atoms, which can be unsubstituted or substituted with Cl, F, Br, or an alkoxy of up to four carbon atoms; and a cross-linking monomer having two or more ethylenically unsaturated groups.
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8.发明授权
公开(公告)号：EP0799219B1
公开(公告)日：2003-05-07
申请号：EP95944517.2
申请日：1995-12-21
Applicant: ALCON LABORATORIES, INC.
Inventor： HELLBERG, Mark , GRAFF, Gustav , GAMACHE, Daniel, A. , NIXON, Jon, C. , GARNER, William, H.
IPC: C07D311/72 , A61K31/355 , C07D307/80 , A61K31/34 , C07C235/34 , A61K31/16 , C07D317/60 , A61K31/36
CPC classification number: A61K31/343 , A61K31/353 , A61K31/355 , A61K47/545 , C07C235/34 , C07D307/80 , C07D311/72
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公开(公告)号：EP0914169A3
公开(公告)日：2002-08-28
申请号：EP98925025.3
申请日：1998-05-29
Applicant: ALCON LABORATORIES, INC.
Inventor： GRAFF, Gustav , KARAKELLE, Mutlu , SHEETS, John, W., Jr. , YANNI, John, M.
IPC: A61L31/00
CPC classification number: A61L31/048 , Y10S623/901 , C08L33/04
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