公开(公告)号：WO1998017173A1

公开(公告)日：1998-04-30

申请号：PCT/US1996016987

申请日：1996-10-22

Applicant: GEVINS, Alan, S. ,  LE, Jian

IPC: A61B05/0476

CPC classification number: A61B5/1077 ,  A61B5/0478

Abstract: The spatial resolution of electroencephalograph (EEG) medical images is improved using "Deblurring" based on a digital computer based analysis using volumetric finite elements, and a biophysical model of the passive electrical conductivity of a subject's head.

Abstract translation: 脑电图（EEG）医学图像的空间分辨率使用基于使用体积有限元素的基于数字计算机的分析的“Deblurring”以及受试者头部的被动导电性的生物物理模型被改进。

公开(公告)号：WO1997026823A1

公开(公告)日：1997-07-31

申请号：PCT/US1997001037

申请日：1997-01-21

Applicant: UNIVERSITY OF KANSAS

Inventor： UNIVERSITY OF KANSAS ,  DORFMEISTER, Josef ,  FREI, Mark ,  LERNER, David ,  OSORIO, Ivan ,  RALSTON, John

IPC: A61B05/0476

CPC classification number: A61B5/415 ,  A61B5/048 ,  A61B5/4094 ,  A61B5/7257 ,  A61B5/726 ,  A61N1/08 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36135 ,  G06F19/00

Abstract: A system (10) analyzes signals representative of a subject's brain activity in a signal processor (12) for information indicating the subject's current activity state and for predicting a change in the activity state. One preferred embodiment uses a combination of nonlinear filtering methods to perform real-time analysis of the electro-encephalogram (EEG) or electro-corticogram (ECoG) signals from a subject patient for information indicative of or predictive of a seizure, and to complete the needed analysis at least before clinical seizure onset. The preferred system then performs an output task for prevention or abatement of the seizure, or for recording pertinent data.

Abstract translation: 系统（10）在信号处理器（12）中分析表示受试者的大脑活动的信号，用于指示受试者的当前活动状态的信息，以及用于预测活动状态的变化。 一个优选实施例使用非线性滤波方法的组合来执行来自对象患者的电脑电图（EEG）或电皮质图（ECoG）信号的实时分析，用于指示或预测癫痫发作的信息，并且完成 至少在临床癫痫发作前需要进行分析。 优选的系统然后执行输出任务以防止或减少缉获量，或用于记录相关数据。

公开(公告)号：WO1993003670A1

公开(公告)日：1993-03-04

申请号：PCT/US1992006789

申请日：1992-08-12

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  LEUCHTER, Andrew, F. ,  COOK, Ian, A.

IPC: A61B05/0476

CPC classification number: A61B5/048 ,  A61B5/4088

Abstract: Determining brain lesions by quantified electroencephalography is effected by obtaining absolute power data in a primary frequency domain for a brain region. Power data in the primary frequency domain in relation to power in a secondary frequency domain is determined. The two sets of data are related to obtain a value representative of the electrical ouput in the brain region. The representative value is compared to as selected base value and quantified departures are mapped topographically. This map is used to identify and assess lesions associated with disorders and afflictions including dementia and demyelinating diseases. Mapping is used to determine activation during tasks such as motor and memory task, cognitive processing or other conditions, and also to assess the level of perfusion of the brain. The apparatus includes electrodes (11, 12, 13, 14, and 15) attached to the head of a patient.

公开(公告)号：WO1991019453A1

公开(公告)日：1991-12-26

申请号：PCT/NL1991000096

申请日：1991-06-13

Applicant: STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN ,  CLUITMANS, Petrus, Johannes, Maria

Inventor： STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN

IPC: A61B05/0476

CPC classification number: A61B5/4821 ,  A61B5/04845

Abstract: Method for determining the anaesthetic depth of a patient, comprising the repeated administering of sensory stimuli to the patient; the repeated, non-invasive recording of the electrical activity of the patient's brain during a measurement interval following each stimulus; the computation, from a number of measurement intervals, of a representation of the response of a sensory neural pathway to a single stimulus; and the determination of the latencies and amplitudes of maxima and minima in the representation, which are a measure of the anaesthetic depth, wherein the measurement intervals are chosen such that they partially overlap one another. Preferably the length of time between two successive stimuli is a stochastic variable having a negative exponential distribution, the computed representation being the first order kernel.

Abstract translation: 用于确定患者的麻醉深度的方法，包括向患者反复施用感觉刺激; 在每个刺激之后的测量间隔期间重复地，非侵入性地记录患者脑的电活动; 从多个测量间隔计算感觉神经通路对单个刺激的反应的表示; 以及在表示中确定最大值和最小值的延迟和幅度，其是麻醉剂深度的量度，其中选择测量间隔使得它们彼此部分重叠。 优选地，两个连续刺激之间的时间长度是具有负指数分布的随机变量，所计算的表示是第一阶内核。

公开(公告)号：WO1997037590A1

公开(公告)日：1997-10-16

申请号：PCT/AU1997000227

申请日：1997-04-10

Applicant: UNIVERSITY OF TECHNOLOGY, SYDNEY ,  KIRKUP, Leslie ,  SEARLE, Andrew, Peter ,  CRAIG, Ashley, Ronald ,  McISAAC, Paul, Francis

Inventor： UNIVERSITY OF TECHNOLOGY, SYDNEY

IPC: A61B05/0476

CPC classification number: A61B5/0482 ,  A61B5/7242 ,  A61B2562/0215

Abstract: The invention concerns an EEG based activation system that may be used to turn an appliance ON or OFF. EEG signals have been used for control purposes using biofeedback methods. However, the drawbacks of this are the learning time required by a subject which may take days or months. The present invention provides a simplified EEG based system for activation of an appliance. The system has an input port to receive electrical signals from scalp electrodes (2, 3), an amplifier (5) to amplify the signals, a bandpass filter (6) to filter the signals and a signal averager (8) to smooth out the signals. Furthermore, the signal averager integrates any received signal in the passband of the filter and provides a ramping output, and the integrating time constant being between one and five seconds.

Abstract translation: 本发明涉及可用于打开或关闭设备的基于EEG的激活系统。 使用生物反馈方法已经将EEG信号用于控制目的。 但是，这样做的缺点是受试者所需的学习时间可能需要几天或几个月。 本发明提供了一种用于激活器具的简化的基于EEG的系统。 该系统具有用于从头皮电极（2,3）接收电信号的输入端口，用于放大信号的放大器（5），滤波信号的带通滤波器（6）和平滑器（8） 信号。 此外，信号平均器将滤波器的通带中的任何接收信号进行积分并提供斜坡输出，并且积分时间常数在1至5秒之间。

公开(公告)号：WO1997010747A1

公开(公告)日：1997-03-27

申请号：PCT/US1996015231

申请日：1996-09-18

Applicant: CLEVELAND MEDICAL DEVICES, INC.

Inventor： CLEVELAND MEDICAL DEVICES, INC. ,  SCHMIDT, Robert, N. ,  HENDRIX, Steven, P. ,  BUCKETT, James, R.

IPC: A61B05/0476

CPC classification number: A61B5/0006 ,  A61B5/04845 ,  A61B2560/0412

Abstract: This invention is a wireless EEG system (10) for effective auditory evoked response comprising an electrode array (12), which attaches to a person and senses voltages produced by the brain electrical activity; a transmitter (18), for producing a radio frequency signal corresponding to the voltages sensed by the electrode array (12); a receiving device (20) for receiving the radio frequency signal; and an operator interface device (22) connected to the receiver (20) for recording a verbal stimulus given by an individual and displaying data output. The transmitter (18) utilizes a carrier frequency shift keyed circuitry to modulate a phase locked loop synthesized carrier frequency and a reference frequency to allow for non-return to zero format obviating the need for Manchester encoding.

Abstract translation: 本发明是一种用于有效听觉诱发反应的无线EEG系统（10），包括：电极阵列（12），其连接到人并感测由脑电活动产生的电压; 发射器（18），用于产生对应于由电极阵列（12）感测的电压的射频信号; 接收装置（20），用于接收射频信号; 以及连接到所述接收器（20）的用于记录由个体给出的语言刺激并显示数据输出的操作者界面装置（22）。 发射机（18）利用载波频移键控电路来调制锁相环合成载波频率和参考频率，以允许不归零格式，从而避免需要曼彻斯特编码。

公开(公告)号：WO1996029928A1

公开(公告)日：1996-10-03

申请号：PCT/SE1996000402

申请日：1996-03-28

Applicant: SCS MEDICINPROJECT AKTIEBOLAG ,  GÄNSLER, Tomas ,  HANSSON, Maria

Inventor： SCS MEDICINPROJECT AKTIEBOLAG

IPC: A61B05/0476

CPC classification number: A61B5/0484 ,  A61B5/04845 ,  A61B5/1106 ,  A61B5/4821 ,  A61B5/6814 ,  A61B2505/05

Abstract: The invention relates to a method and a device for determining and monitoring the degree of narcosis in a subject. The determination proceeds as follows. Auditory stimuli are generated by means of a stimulus generator (1). Response signals which signalise the response of the auditory chain to said stimuli are picked up by means of electrodes (4) on the patient's head (3). The response signals are converted by a digitiser into digital response signals. For each digital response signal, an implementation is generated by selecting a portion of the digital response signal. A signal processing means (7) is arranged, by means of which a first and a second mean signal of implementations is formed and by means of which the second mean signal is adapted to the first mean signal for forming an adapted mean signal. Finally, a waveform estimate of the adapted mean signal is formed with the aid of the signal processing means. For monitoring the degree of narcosis, it is possible either to study the actual waveform estimate or to determine and study some suitable parameter, which is dependent on the degree of narcosis, in the waveform estimate.

Abstract translation: 本发明涉及一种用于确定和监测受试者的麻醉程度的方法和装置。 确定进行如下。 听觉刺激通过刺激发生器（1）产生。 通过患者头部（3）上的电极（4）拾取将听觉链响应于所述刺激的响应信号。 响应信号由数字转换器转换成数字响应信号。 对于每个数字响应信号，通过选择数字响应信号的一部分来产生实现。 信号处理装置（7）被布置，通过该信号处理装置形成实现的第一和第二平均信号，并且通过该信号处理装置将第二平均信号适用于形成适应的平均信号的第一平均信号。 最后，借助于信号处理装置形成适应平均信号的波形估计。 为了监测麻醉程度，有可能在波形估计中研究实际波形估计或确定和研究一些取决于麻醉程度的适当参数。

公开(公告)号：WO1998027864A1

公开(公告)日：1998-07-02

申请号：PCT/US1997023624

申请日：1997-12-19

Applicant: ASPECT MEDICAL SYSTEMS, INC.

Inventor： ASPECT MEDICAL SYSTEMS, INC. ,  GREENWALD, Scott, D. ,  SMITH, Charles, P.

IPC: A61B05/0476

CPC classification number: A61B5/0476 ,  A61B5/7217

Abstract: The disclosed filter (120) removes cardiac artifacts (310) from signals representative of a patient's cerebral activity. The filter preferably replaces portions of the signal including artifacts with temporally adjacent artifact free portions.

Abstract translation: 所公开的过滤器（120）从代表患者脑活动的信号中去除心脏假象（310）。 滤波器优选地替换信号的部分，包括与时间上相邻的无伪影部分的伪影。

公开(公告)号：WO1995015117A1

公开(公告)日：1995-06-08

申请号：PCT/US1994006603

申请日：1994-06-22

Applicant: UNIVERSITY OF WASHINGTON

Inventor： UNIVERSITY OF WASHINGTON ,  LOCKARD, Joan, S. ,  DuCHARME, Larry, L. ,  CONGDON, William, C., Jr. ,  KALK, Douglas, F.

IPC: A61B05/0476

CPC classification number: A61B5/048 ,  A61B5/4094

Abstract: A method and apparatus for accurately determining the onset or occurrence of an epileptic seizure is disclosed. The system includes an electroencephalograph (EEG) (16a) and an electromyograph (EMG) (16b) which provide signals to signal processors (17a, 17b). The signal processor operates to generate a digitized envelope wave form of th EEG wave form and the EMG waveform. If the waveforms all have an amplitude within a predetermined threshold, for a predetermined time interval, a CPU (21) provides a signal to an output display (23) indicative of an epileptic seizure.

Abstract translation: 公开了一种准确地确定癫痫发作发作或发生的方法和装置。 该系统包括向信号处理器（17a，17b）提供信号的脑电图仪（EEG）（16a）和肌电图（EMG）（16b）。 信号处理器操作以产生EEG波形和EMG波形的数字化包络波形式。 如果波形全都具有预定阈值内的幅度，则在预定的时间间隔内，CPU（21）向指示癫痫发作的输出显示器（23）提供信号。

公开(公告)号：WO1994012100A1

公开(公告)日：1994-06-09

申请号：PCT/FI1993000504

申请日：1993-11-30

Applicant: ILMONIEMI, Risto

IPC: A61B05/0476

CPC classification number: A61B5/04008

Abstract: The present invention is related to a method and an apparatus for separating the different components of evoked responses and spontaneous activity of the brain, as well as signals measured from the heart, from each other. The apparatus according to the invention presents the measured signals in graphic form and the user selects from the signals such a time instant, time interval or frequency band, which plausibly can be related to a given source component. The apparatus forms a signal vector from the temporal or frequency signals thus selected, projects the unprocessed signal onto the signal vector thus formed, and subtracts the projection from the unprocessed signals, whereby the projected vector and the set of signals remaining after the subtraction step provide the separation of the unprocessed signals into the selected component and such a part which is clean of contribution of the selected component.

Abstract translation: 本发明涉及一种用于分离诱发反应的不同组分和脑的自发活动以及从心脏测量的信号的方法和装置。 根据本发明的装置以图形形式呈现测量的信号，并且用户从诸如可能与给定源分量相关的时刻，时间间隔或频带的信号中进行选择。 该装置从如此选择的时间或频率信号形成信号向量，将未处理的信号投射到如此形成的信号矢量上，并从未处理的信号中减去投影，由此在减法步骤之后剩余的投影向量和信号集合提供 将未处理的信号分离成所选择的部件，以及清洁所选部件的贡献的部件。