公开(公告)号：WO2009005675A1

公开(公告)日：2009-01-08

申请号：PCT/US2008/007926

申请日：2008-06-26

Applicant: ABBOTT LABORATORIES ,  CALDERWOOD, David J. ,  BONAFOUX, Dominique F. ,  BURCHAT, Andrew ,  DING, Ping ,  FRANK, Kristine E. ,  HOEMANN, Michael Z. ,  MULLEN, Kelly D. ,  DAVIS, Heather M.

Inventor： CALDERWOOD, David J. ,  BONAFOUX, Dominique F. ,  BURCHAT, Andrew ,  DING, Ping ,  FRANK, Kristine E. ,  HOEMANN, Michael Z. ,  MULLEN, Kelly D. ,  DAVIS, Heather M.

IPC: A61K31/535 ,  A61K31/50 ,  A61K31/519

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The present invention is directed to novel compounds of formula (I), wherein the variables are defined as herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

Abstract translation: 本发明涉及新的式（I）化合物，其中变量如本文所定义。 式（I）化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性疾病和病症，例如癌症。

公开(公告)号：WO2003080064A1

公开(公告)日：2003-10-02

申请号：PCT/US2003/008950

申请日：2003-03-21

Applicant: ABBOTT LABORATORIES ,  HIRST, Gavin, C. ,  ARNOLD, Lee, D. ,  BURCHAT, Andrew ,  WISHART, Neil ,  CALDERWOOD, David ,  WADA, Carol, K. ,  MICHAELIDES, Michael, R. ,  JI, Zhiqin ,  MUCKEY, Melanie

Inventor： HIRST, Gavin, C. ,  ARNOLD, Lee, D. ,  BURCHAT, Andrew ,  WISHART, Neil ,  CALDERWOOD, David ,  WADA, Carol, K. ,  MICHAELIDES, Michael, R. ,  JI, Zhiqin ,  MUCKEY, Melanie

IPC: A61K31/519

CPC classification number: C07D487/04 ,  C07D491/04

Abstract: The present application is directed to pyrazolopyrimidine and furopyrimidine analogs of the formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.

Abstract translation: 本申请涉及式（I）的吡唑并嘧啶和呋喃嘧啶类似物，其中取代基如本文所定义，其可用作激酶抑制剂。

公开(公告)号：WO2007117465A2

公开(公告)日：2007-10-18

申请号：PCT/US2007/008307

申请日：2007-04-02

Applicant: ABBOTT LABORATORIES ,  ERICSSON, Anna M. ,  BURCHAT, Andrew ,  FRANK, Kristine E. ,  CALDERWOOD, David J. ,  ABBOTT, Lily K. ,  ARGIRIADI, Maria A. ,  BORHANI, David W. ,  CUSACK, Kevin P. ,  DIXON, Richard W. ,  GORDON, Thomas D. ,  MULLEN, Kelly D. ,  TALANIAN, Robert V. ,  WU, Xiaoyun ,  ZHANG, Xiaolei ,  WANG, Lu X. ,  LI, Biqin ,  BARBERIS, Claude E. ,  WISHART, Neil

Inventor： ERICSSON, Anna M. ,  BURCHAT, Andrew ,  FRANK, Kristine E. ,  CALDERWOOD, David J. ,  ABBOTT, Lily K. ,  ARGIRIADI, Maria A. ,  BORHANI, David W. ,  CUSACK, Kevin P. ,  DIXON, Richard W. ,  GORDON, Thomas D. ,  MULLEN, Kelly D. ,  TALANIAN, Robert V. ,  WU, Xiaoyun ,  ZHANG, Xiaolei ,  WANG, Lu X. ,  LI, Biqin ,  BARBERIS, Claude E. ,  WISHART, Neil

IPC: A61K31/5377

CPC classification number: C07D487/04 ,  C07D403/12 ,  C07D403/14 ,  C07D409/04 ,  C07D409/14

Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.

Abstract translation: 式（I）的新型化合物或其药学上可接受的盐，前体药物和式（I）的生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。

公开(公告)号：WO2012149280A2

公开(公告)日：2012-11-01

申请号：PCT/US2012/035401

申请日：2012-04-27

Applicant: ABBOTT LABORATORIES ,  FRANK, Kristine E. ,  BURCHAT, Andrew ,  COX, Philip ,  IHLE, David C. ,  MULLEN, Kelly D. ,  SOMAL, Gagandeep ,  VASUDEVAN, Anil ,  WANG, Lu ,  WILSON, Noel S.

Inventor： FRANK, Kristine E. ,  BURCHAT, Andrew ,  COX, Philip ,  IHLE, David C. ,  MULLEN, Kelly D. ,  SOMAL, Gagandeep ,  VASUDEVAN, Anil ,  WANG, Lu ,  WILSON, Noel S.

IPC: A61K31/519

CPC classification number: C07D487/14

Abstract: The invention provides compounds of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract translation: 本发明提供式（I）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。

公开(公告)号：WO2012125797A1

公开(公告)日：2012-09-20

申请号：PCT/US2012/029184

申请日：2012-03-15

Applicant: ABBOTT LABORATORIES ,  CUSACK, Kevin P. ,  GORDON, Thomas D. ,  IHLE, David C. ,  HAYES, Martin E. ,  BREINLINGER, Eric C. ,  ERICSSON, Anna M. ,  LI, Bin ,  WANG, Lei ,  MARTINEZ, Gloria Y. ,  BURCHAT, Andrew ,  HOBSON, Adrian D. ,  MULLEN, Kelly D. ,  FRIEDMAN, Michael ,  MORYTKO, Michael, J.

Inventor： CUSACK, Kevin P. ,  GORDON, Thomas D. ,  IHLE, David C. ,  HAYES, Martin E. ,  BREINLINGER, Eric C. ,  ERICSSON, Anna M. ,  LI, Bin ,  WANG, Lei ,  MARTINEZ, Gloria Y. ,  BURCHAT, Andrew ,  HOBSON, Adrian D. ,  MULLEN, Kelly D. ,  FRIEDMAN, Michael ,  MORYTKO, Michael, J.

IPC: A01N27/00 ,  A61K31/015

CPC classification number: C07D213/75 ,  C07B2200/07 ,  C07C45/62 ,  C07C45/72 ,  C07C45/74 ,  C07C49/755 ,  C07D231/54 ,  C07D235/18 ,  C07D241/20 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D453/04 ,  C07D487/06 ,  C07D491/20 ,  C07C49/67

Abstract: The invention provides a compound of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract translation: 本发明提供式（I）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。

公开(公告)号：EP1496910A1

公开(公告)日：2005-01-19

申请号：EP03718039.5

申请日：2003-03-21

Applicant: Abbott Laboratories

Inventor： HIRST, Gavin, C. ,  ARNOLD, Lee, D. ,  BURCHAT, Andrew ,  WISHART, Neil ,  CALDERWOOD, David ,  WADA, Carol, K. ,  MICHAELIDES, Michael, R. ,  JI, Zhiqin ,  MUCKEY, Melanie

IPC: A61K31/519 ,  C07D487/02 ,  C07D473/00 ,  C07D471/00 ,  C07D487/00 ,  C07D491/00

CPC classification number: C07D487/04 ,  C07D491/04

Abstract: The present application is directed to pyrazolopyrimidine and furopyrimidine analogs of the formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.

Abstract translation: 本申请涉及吡唑并嘧啶和式（I），其中取代基如本文所定义的furopyrimidine类似物，其是作为激酶抑制剂是有用的。

公开(公告)号：EP2001480A2

公开(公告)日：2008-12-17

申请号：EP07754773.5

申请日：2007-04-02

Applicant: ABBOTT LABORATORIES

Inventor： ERICSSON, Anna M. ,  BURCHAT, Andrew ,  FRANK, Kristine E. ,  CALDERWOOD, David J. ,  ABBOTT, Lily K. ,  ARGIRIADI, Maria A. ,  BORHANI, David W. ,  CUSACK, Kevin P. ,  DIXON, Richard W. ,  GORDON, Thomas D. ,  MULLEN, Kelly D. ,  TALANIAN, Robert V. ,  WU, Xiaoyun ,  ZHANG, Xiaolei ,  WANG, Lu X. ,  LI, Biqin ,  BARBERIS, Claude E. ,  WISHART, Neil

IPC: A61K31/5377

CPC classification number: C07D487/04 ,  C07D403/12 ,  C07D403/14 ,  C07D409/04 ,  C07D409/14

Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.

Abstract translation: 式（I）的新化合物或其式（I）的药用盐，前药和生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。

公开(公告)号：EP2170337A1

公开(公告)日：2010-04-07

申请号：EP08779770.0

申请日：2008-06-26

Applicant: Abbott Laboratories

Inventor： CALDERWOOD, David J. ,  BONAFOUX, Dominique F. ,  BURCHAT, Andrew ,  DING, Ping ,  FRANK, Kristine E. ,  HOEMANN, Michael Z. ,  MULLEN, Kelly D. ,  DAVIS, Heather M.

IPC: A61K31/535 ,  A61K31/50 ,  A61K31/519

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The present invention is directed to novel compounds of formula (I) wherein the variables are defined as herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.