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公开(公告)号：WO2007117465A2
公开(公告)日：2007-10-18
申请号：PCT/US2007/008307
申请日：2007-04-02
Applicant: ABBOTT LABORATORIES , ERICSSON, Anna M. , BURCHAT, Andrew , FRANK, Kristine E. , CALDERWOOD, David J. , ABBOTT, Lily K. , ARGIRIADI, Maria A. , BORHANI, David W. , CUSACK, Kevin P. , DIXON, Richard W. , GORDON, Thomas D. , MULLEN, Kelly D. , TALANIAN, Robert V. , WU, Xiaoyun , ZHANG, Xiaolei , WANG, Lu X. , LI, Biqin , BARBERIS, Claude E. , WISHART, Neil
Inventor： ERICSSON, Anna M. , BURCHAT, Andrew , FRANK, Kristine E. , CALDERWOOD, David J. , ABBOTT, Lily K. , ARGIRIADI, Maria A. , BORHANI, David W. , CUSACK, Kevin P. , DIXON, Richard W. , GORDON, Thomas D. , MULLEN, Kelly D. , TALANIAN, Robert V. , WU, Xiaoyun , ZHANG, Xiaolei , WANG, Lu X. , LI, Biqin , BARBERIS, Claude E. , WISHART, Neil
IPC: A61K31/5377
CPC classification number: C07D487/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/14
Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
Abstract translation: 式（I）的新型化合物或其药学上可接受的盐，前体药物和式（I）的生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。
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公开(公告)号：WO2011068899A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/058598
申请日：2010-12-01
Applicant: ABBOTT LABORATORIES , WISHART, Neil , ARGIRIADI, Maria A. , BREINLINGER, Eric C. , CALDERWOOD, David J. , ERICSSON, Anna M. , FIAMENGO, Bryan A. , FRANK, Kristine E. , FRIEDMAN, Michael , GEORGE, Dawn M. , GOEDKEN, Eric R. , JOSEPHSOHN, Nathan S. , LI, Biqin C. , MORYTKO, Michael J. , MULLEN, Kelly D. , SOMAL, Gagandeep , STEWART, Kent D. , VOSS, Jeffrey W. , WALLACE, Grier A. , WANG, Lu , WOLLER, Kevin R.
Inventor： WISHART, Neil , ARGIRIADI, Maria A. , BREINLINGER, Eric C. , CALDERWOOD, David J. , ERICSSON, Anna M. , FIAMENGO, Bryan A. , FRANK, Kristine E. , FRIEDMAN, Michael , GEORGE, Dawn M. , GOEDKEN, Eric R. , JOSEPHSOHN, Nathan S. , LI, Biqin C. , MORYTKO, Michael J. , MULLEN, Kelly D. , SOMAL, Gagandeep , STEWART, Kent D. , VOSS, Jeffrey W. , WALLACE, Grier A. , WANG, Lu , WOLLER, Kevin R.
CPC classification number: C07F9/06 , C07D471/14 , C07D487/14 , C07D498/14 , C07D513/14
Abstract: The invention provides a compound of Formula (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ii), (Ij), (Ik), or (Il) as defined herein, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
Abstract translation: 本发明提供了式（Ia），（Ib），（Ic），（Id），（Ie），（If），（Ig），（Ih），（Ii），（Ij），（Ik） ，或（II），其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号：WO2009005675A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/007926
申请日：2008-06-26
Applicant: ABBOTT LABORATORIES , CALDERWOOD, David J. , BONAFOUX, Dominique F. , BURCHAT, Andrew , DING, Ping , FRANK, Kristine E. , HOEMANN, Michael Z. , MULLEN, Kelly D. , DAVIS, Heather M.
Inventor： CALDERWOOD, David J. , BONAFOUX, Dominique F. , BURCHAT, Andrew , DING, Ping , FRANK, Kristine E. , HOEMANN, Michael Z. , MULLEN, Kelly D. , DAVIS, Heather M.
IPC: A61K31/535 , A61K31/50 , A61K31/519
CPC classification number: C07D487/04 , C07D519/00
Abstract: The present invention is directed to novel compounds of formula (I), wherein the variables are defined as herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
Abstract translation: 本发明涉及新的式（I）化合物，其中变量如本文所定义。 式（I）化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性疾病和病症，例如癌症。
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公开(公告)号：WO2012151158A1
公开(公告)日：2012-11-08
申请号：PCT/US2012/035832
申请日：2012-04-30
Applicant: ABBOTT LABORATORIES , CALDERWOOD, David J. , BREINLINGER, Eric C. , SWANN, Steven L. , MUKHERJEE, Subhendu , CHITTY, Venkata Srikanth , THUNUGUNTLA, Siva Sanjeeva Rao , HOSAHALLI, Subramanyah Seetharama Shastry
Inventor： CALDERWOOD, David J. , BREINLINGER, Eric C. , SWANN, Steven L. , MUKHERJEE, Subhendu , CHITTY, Venkata Srikanth , THUNUGUNTLA, Siva Sanjeeva Rao , HOSAHALLI, Subramanyah Seetharama Shastry
IPC: A61K31/422
CPC classification number: A61K31/506 , A61K31/5377 , A61K31/541 , C07D413/04 , C07D413/12 , C07D413/14 , Y02A50/401 , Y02A50/463 , Y02A50/481
Abstract: The present invention provides compound of Formula (1) biologically active metabolites, pro-drugs, isomers, stereoisomers, solvates, hydrates and pharmaceutically acceptable salts thereof wherein the variables are defined herein. The compounds of the invention are useful for treating immunological conditions. X is an optionally substituted ring system which is aromatic, partly aromatic or non-aromatic having one or more fused ring systems.
Abstract translation: 本发明提供了式（1）化合物的生物活性代谢物，前药，异构体，立体异构体，溶剂合物，水合物及其药学上可接受的盐，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学病症。 X是任选取代的环系，其是具有一个或多个稠环体系的芳香族，部分芳族或非芳族的。
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Patent Agency Ranking
公开(公告)号：WO2008118485A1
公开(公告)日：2008-10-02
申请号：PCT/US2008/004007
申请日：2008-03-27
Applicant: ABBOTT LABORATORIES , CALDERWOOD, David J. , FRANK, Kristine E. , BETSCHMANN, Patrick , BREINLINGER, Eric C. , DIXON, Richard W.
Inventor： CALDERWOOD, David J. , FRANK, Kristine E. , BETSCHMANN, Patrick , BREINLINGER, Eric C. , DIXON, Richard W.
IPC: A01N43/58 , A61K31/50 , C07D471/00
CPC classification number: C07D487/04
Abstract: The present invention is directed to novel imidazopyrazine compounds useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
Abstract translation: 本发明涉及用作激酶抑制剂的新颖的咪唑并嗪化合物，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性病症和病症，例如癌症。
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公开(公告)号：EP2068869A2
公开(公告)日：2009-06-17
申请号：EP07870771.8
申请日：2007-10-05
Applicant: ABBOTT LABORATORIES
Inventor： BORHANI, David W. , CALDERWOOD, David J. , FRANK, Kristine E. , DAVIS, Heather M. , JOSEPHSOHN, Nathan S. , SKINNER, Barbara S.
IPC: A61K31/41 , C07D257/04
CPC classification number: C07D498/04 , C07D513/04 , C07D519/00
Abstract: The present invention is directed to novel compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
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公开(公告)号：EP2001480A2
公开(公告)日：2008-12-17
申请号：EP07754773.5
申请日：2007-04-02
Applicant: ABBOTT LABORATORIES
Inventor： ERICSSON, Anna M. , BURCHAT, Andrew , FRANK, Kristine E. , CALDERWOOD, David J. , ABBOTT, Lily K. , ARGIRIADI, Maria A. , BORHANI, David W. , CUSACK, Kevin P. , DIXON, Richard W. , GORDON, Thomas D. , MULLEN, Kelly D. , TALANIAN, Robert V. , WU, Xiaoyun , ZHANG, Xiaolei , WANG, Lu X. , LI, Biqin , BARBERIS, Claude E. , WISHART, Neil
IPC: A61K31/5377
CPC classification number: C07D487/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/14
Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
Abstract translation: 式（I）的新化合物或其式（I）的药用盐，前药和生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。
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公开(公告)号：EP2170337A1
公开(公告)日：2010-04-07
申请号：EP08779770.0
申请日：2008-06-26
Applicant: Abbott Laboratories
Inventor： CALDERWOOD, David J. , BONAFOUX, Dominique F. , BURCHAT, Andrew , DING, Ping , FRANK, Kristine E. , HOEMANN, Michael Z. , MULLEN, Kelly D. , DAVIS, Heather M.
IPC: A61K31/535 , A61K31/50 , A61K31/519
CPC classification number: C07D487/04 , C07D519/00
Abstract: The present invention is directed to novel compounds of formula (I) wherein the variables are defined as herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
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公开(公告)号：EP2139329A1
公开(公告)日：2010-01-06
申请号：EP08742312.5
申请日：2008-03-27
Applicant: ABBOTT LABORATORIES
Inventor： CALDERWOOD, David J. , FRANK, Kristine E. , BETSCHMANN, Patrick , BREINLINGER, Eric C. , DIXON, Richard W.
IPC: A01N43/58 , A61K31/50 , C07D471/00
CPC classification number: C07D487/04
Abstract: The present invention is directed to novel imidazopyrazine compounds useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
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