公开(公告)号：EP1609790A2

公开(公告)日：2005-12-28

申请号：EP05106190.1

申请日：1997-02-12

Applicant: ABBOTT LABORATORIES

Inventor： Winn, Martin ,  Henry, Kenneth J. Jr. ,  Liu, Gang ,  Wittenberger, Steven J. ,  King, Steven A. ,  Boyd, Steven A. ,  Hutchins, Charles W. ,  Jae, Hwan-Soo ,  Tasker, Andrew S. ,  Von Geldern, Thomas W. ,  Kester, Jeffrey A. ,  Sorensen, Bryan K. ,  Szczepankiewicz, Bruce G.

IPC: C07D405/04 ,  C07D405/12 ,  A61K31/40 ,  A61K31/41 ,  A61K31/435

CPC classification number: C07D401/04 ,  C07D207/16 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  Y02P20/55

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

Abstract translation: 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。

公开(公告)号：EP2500347A1

公开(公告)日：2012-09-19

申请号：EP12155361.4

申请日：2008-04-30

Applicant: Abbott Laboratories

Inventor： Liu, Gang ,  Xin, Zhili ,  Kym, Philip R. ,  Souers, Andrew J

IPC: C07D487/04 ,  A61K31/519 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10

CPC classification number: C07D487/04

Abstract: The present invention relates to compounds of formula (I): wherein R 1 , R 2 , and R 3 , are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.

Abstract translation: 本发明涉及式（I）化合物：其中R 1，R 2和R 3在本文中定义。 还公开了治疗DGAT-1相关疾病或病症的药物组合物和方法。

公开(公告)号：EP1481968A2

公开(公告)日：2004-12-01

申请号：EP04020808.4

申请日：2000-04-03

Applicant: Abbott Laboratories

Inventor： Link, James ,  Liu, Gang ,  Pei, Zhonghua ,  von Geldern, Thomas W. ,  Winn, Martin ,  Xin, Zhili ,  Wang, Sheldon ,  Boyd, Steven A. ,  Zhu, Gui-Dong ,  Freeman, Jennifer C. ,  Gunawardana, Indrani W. ,  Staeger, Michael A. ,  Jae, Hwan-Soo ,  Lynch, John K.

IPC: C07D207/16 ,  C07D211/60 ,  C07D211/62 ,  C07D295/18 ,  C07D401/04 ,  A61K31/165 ,  A61K31/33 ,  A61P29/00

CPC classification number: C07D207/27 ,  C07C323/62 ,  C07C2601/02 ,  C07D205/04 ,  C07D207/09 ,  C07D207/14 ,  C07D207/16 ,  C07D209/08 ,  C07D211/20 ,  C07D211/22 ,  C07D211/46 ,  C07D211/60 ,  C07D211/62 ,  C07D213/40 ,  C07D213/74 ,  C07D213/81 ,  C07D217/02 ,  C07D217/06 ,  C07D231/12 ,  C07D233/56 ,  C07D241/04 ,  C07D249/08 ,  C07D295/185 ,  C07D295/26 ,  C07D307/68 ,  C07D317/66 ,  C07D401/04 ,  C07D401/12

Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R 1 to R 5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.

公开(公告)号：EP1609790A3

公开(公告)日：2006-01-04

申请号：EP05106190.1

申请日：1997-02-12

Applicant: ABBOTT LABORATORIES

Inventor： Winn, Martin ,  Henry, Kenneth J. Jr. ,  Liu, Gang ,  Wittenberger, Steven J. ,  King, Steven A. ,  Boyd, Steven A. ,  Hutchins, Charles W. ,  Jae, Hwan-Soo ,  Tasker, Andrew S. ,  Von Geldern, Thomas W. ,  Kester, Jeffrey A. ,  Sorensen, Bryan K. ,  Szczepankiewicz, Bruce G.

IPC: C07D405/04 ,  C07D405/12 ,  A61K31/40 ,  A61K31/41 ,  A61K31/435

CPC classification number: C07D401/04 ,  C07D207/16 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  Y02P20/55

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

公开(公告)号：EP1481968A3

公开(公告)日：2005-01-19

申请号：EP04020808.4

申请日：2000-04-03

Applicant: Abbott Laboratories

Inventor： Link, James ,  Liu, Gang ,  Pei, Zhonghua ,  von Geldern, Thomas W. ,  Winn, Martin ,  Xin, Zhili ,  Wang, Sheldon ,  Boyd, Steven A. ,  Zhu, Gui-Dong ,  Freeman, Jennifer C. ,  Gunawardana, Indrani W. ,  Staeger, Michael A. ,  Jae, Hwan-Soo ,  Lynch, John K.

IPC: C07C323/62 ,  C07D233/61 ,  C07D207/26 ,  C07D295/18 ,  C07D213/74 ,  C07D211/22 ,  C07D207/14 ,  C07D211/46 ,  C07D211/62 ,  C07D211/60 ,  C07D401/04 ,  C07D217/02 ,  C07D307/68 ,  C07D295/26 ,  C07D317/66 ,  C07D209/08 ,  C07D295/205 ,  C07D401/12 ,  A61K31/165 ,  A61K31/33 ,  A61P29/00

CPC classification number: C07D207/27 ,  C07C323/62 ,  C07C2601/02 ,  C07D205/04 ,  C07D207/09 ,  C07D207/14 ,  C07D207/16 ,  C07D209/08 ,  C07D211/20 ,  C07D211/22 ,  C07D211/46 ,  C07D211/60 ,  C07D211/62 ,  C07D213/40 ,  C07D213/74 ,  C07D213/81 ,  C07D217/02 ,  C07D217/06 ,  C07D231/12 ,  C07D233/56 ,  C07D241/04 ,  C07D249/08 ,  C07D295/185 ,  C07D295/26 ,  C07D307/68 ,  C07D317/66 ,  C07D401/04 ,  C07D401/12

Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R 1 to R 5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Abstract translation: 本发明涉及式（I）的肉桂酰胺化合物，其中R 1至R 5中的至少一个为“顺式 - 酰胺”（a）或“反式肉桂酰胺”（b），其它变量如 可用于治疗炎症和免疫疾病的权利要求，含有这些化合物的药物组合物和抑制哺乳动物炎症或抑制免疫应答的方法。