PHARMACEUTICAL PREPARATION IN SOLID RETARDING FORM

    公开(公告)号:JPH05194197A

    公开(公告)日:1993-08-03

    申请号:JP31006092

    申请日:1992-11-19

    Applicant: BASF AG

    Abstract: PURPOSE: To prepare a sustained release formulation of a solid pharmaceutical preparation by an extruding and continuous forming method for allowing the treatment to successively progress with a high throughput when the material loss is slight. CONSTITUTION: A sustained release formulation is prepared by melt-extruding a mixture of an active ingredient of a pharmaceutical preparation with a polymer melt comprising (a) a water-insoluble poly(meth)acrylate, (b) a water-soluble hydroxyalkyl cellulose having 2-3 carbon atoms in the hydroxyalkyl group or hydroxyalkylmethyl cellulose, or a N-vinylpyrrolidone polymer having vinyl acetate, or a mixture of preceding two, (c) one or more conventional pharmaceutical auxiliaries, and successively forming the molten mixture.

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