公开(公告)号：JPH06172160A

公开(公告)日：1994-06-21

申请号：JP19824593

申请日：1993-08-10

Applicant: BASF AG

Inventor： SUBUEN GURABOFUSUKII ,  AKUSERU ZANNAA ,  IERUKU ROOZENBERUKU

IPC: A01N25/10 ,  A01N25/12 ,  A61K9/14 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26

Abstract: PURPOSE: To provide a solid granular active substance-contg. preparation. CONSTITUTION: This solid granular active substance-contg. preparation is obtd. by tightly mixing the active substance with a water-soluble melt consisting of a) 10 to 90 wt.% water-soluble polymer A having a viscosity Va of 1,000 to 120,000 cPs, b) 10 to 90 wt.% water-soluble polymer B having a viscosity Vb of 1 to 500 cPs (where the viscosities Va and Vb are those of 2 wt.% aq. solns. at 20 deg.C and are measured by a capillartity method stipulated in ASTM D2363-72) as a carrier material and processing and molding the melt to particles.

公开(公告)号：JPH0656651A

公开(公告)日：1994-03-01

申请号：JP15209393

申请日：1993-06-23

Applicant: BASF AG

Inventor： SUBUEN GURABOFUSUKII ,  ASUTORITSUDO KAA HERUBITSUHI ,  AKUSERU ZANNERU ,  KURUTO BUENDERU

IPC: A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K9/28 ,  A61K9/30 ,  A61K9/50 ,  A61K47/04 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38

Abstract: PURPOSE: To obtain a drug excellent in storage stability and persisting property by applying a regenerated and aqueous dispersion liquid of a specified binder on the core containing the effective substance. CONSTITUTION: An aqueous dispersion liquid of a binder is obtd. by emulsion polymn. with a pharmaceutically allowed material such as methylmethacrylate. The obtd. dispersion liquid, a water-soluble and pharmaceutically allowed spray assistant having >=60 deg.C glass transition temp. such as methylcellulose by 5 to 50 wt.% of the binder, and a pharmaceutically allowed adhesion preventive such as talc by 0 to 50 wt.% are spray-dried together and then again prepared as a regenerated and aqueous dispersion liquid. The obtd. liquid is applied on the core containing the effective substance to obtain the drug of the purpose.

公开(公告)号：JPH05247228A

公开(公告)日：1993-09-24

申请号：JP32176692

申请日：1992-12-01

Applicant: BASF AG

Inventor： FUORUKAA BIYUURAA ,  SUBUEN GURABOFUSUKII ,  AKUSERU ZANNAA

IPC: A61K8/81 ,  A61K9/20 ,  A61K9/26 ,  A61K9/28 ,  A61Q5/06 ,  C08F2/04 ,  C08F2/06 ,  C08F2/08 ,  C08F6/12 ,  C08F218/02 ,  C08F218/08 ,  C08F220/04 ,  C08F226/10 ,  C08J3/12 ,  C08L31/04 ,  C08L39/00 ,  C08L39/04 ,  C09D131/04

公开(公告)号：JPH05194198A

公开(公告)日：1993-08-03

申请号：JP26704392

申请日：1992-10-06

Applicant: BASF AG

Inventor： SUBUEN GURABOFUSUKII ,  KURUTO BUENDERU ,  ASUTORIITO KAA HERUBITSUHI

IPC: A61K9/20 ,  A61K9/22 ,  A61K9/28 ,  A61K9/32 ,  A61K9/36 ,  A61K47/30

Abstract: PURPOSE: To obtain the subject powdery mixture useful for tablets, etc., excellent in sustained release, adhesion stability for many hours, redispersible in cold water without using an auxiliary substance, comprising a specific emulsion polymer and an ethylenic unsaturated polymerizable monomer in a specific ratio. CONSTITUTION: This mixture comprises 10-100 wt.% of an emulsion polymer polymerized in the presence of 0.1-2 pts.wt. of a saccharified starch having 2,500-25,000 molecular weight. The polymer is composed of 1 pt.wt. of one or more ethylenic unsaturated polymerizable monomers such as methyl methacrylate.

公开(公告)号：JPH05194197A

公开(公告)日：1993-08-03

申请号：JP31006092

申请日：1992-11-19

Applicant: BASF AG

Inventor： BUINFURIITO MIYURAA ,  RAINHARUTO SHIYUPENGURAA ,  SUBUEN GURABOFUSUKII ,  AKUSERU ZANNAA

IPC: A61K9/20 ,  A61K9/22

Abstract: PURPOSE: To prepare a sustained release formulation of a solid pharmaceutical preparation by an extruding and continuous forming method for allowing the treatment to successively progress with a high throughput when the material loss is slight. CONSTITUTION: A sustained release formulation is prepared by melt-extruding a mixture of an active ingredient of a pharmaceutical preparation with a polymer melt comprising (a) a water-insoluble poly(meth)acrylate, (b) a water-soluble hydroxyalkyl cellulose having 2-3 carbon atoms in the hydroxyalkyl group or hydroxyalkylmethyl cellulose, or a N-vinylpyrrolidone polymer having vinyl acetate, or a mixture of preceding two, (c) one or more conventional pharmaceutical auxiliaries, and successively forming the molten mixture.