公开(公告)号：AU2005281796A1

公开(公告)日：2006-03-16

申请号：AU2005281796

申请日：2005-09-09

Applicant: BASF AG

Inventor： KNOLL ROLF ,  BUDDE ECKHARD ,  VEEN MARKUS ,  LANG CHRISTINE ,  BOETTNER MEWES ,  RYSER MARTIN ,  KAESLER BRUNO

IPC: C12N1/20 ,  A23L13/60 ,  A23L15/00 ,  A23L17/00 ,  A23L27/60 ,  A23L29/00 ,  A61K35/74 ,  A61K35/747 ,  C12R1/225

Abstract: The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention.

公开(公告)号：AU2005281796C1

公开(公告)日：2014-01-23

申请号：AU2005281796

申请日：2005-09-09

Applicant: BASF AG

Inventor： KAESLER BRUNO ,  KNOELL ROLF ,  BOETTNER MEWES ,  BUDDE ECKHARD ,  LANG CHRISTINE ,  RYSER MARTIN ,  VEEN MARKUS

IPC: C12N1/20 ,  A23L13/60 ,  A23L15/00 ,  A23L17/00 ,  A23L27/60 ,  A23L29/00 ,  A61K35/74 ,  A61K35/747 ,  C12R1/225

Abstract: The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention.

公开(公告)号：AU2005281796B2

公开(公告)日：2011-06-16

申请号：AU2005281796

申请日：2005-09-09

Applicant: BASF AG

Inventor： KNOLL ROLF ,  BUDDE ECKHARD ,  VEEN MARKUS ,  LANG CHRISTINE ,  BOETTNER MEWES ,  RYSER MARTIN ,  KAESLER BRUNO

IPC: C12N1/20 ,  A23L13/60 ,  A23L15/00 ,  A23L17/00 ,  A23L27/60 ,  A23L29/00 ,  A61K35/74 ,  A61K35/747 ,  C12R1/225

Abstract: The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention.

公开(公告)号：CA2633657A1

公开(公告)日：2007-04-12

申请号：CA2633657

申请日：2006-09-18

Applicant: BASF AG

Inventor： BOETTNER MEWES ,  LANG CHRISTINE ,  REINDL ANDREAS ,  BUDDE ECKHARD ,  VEEN MARKUS ,  KNOELL ROLF

IPC: C12N1/20 ,  A61K8/99 ,  A61K35/74 ,  A61K35/744 ,  A61K35/747

Abstract: Described are microorganisms which are able to inhibit the formation of foot malodor by skin microorganisms. Also described are compositions comprising such microorganisms as well as the use of such microorganisms in cosmetic, prophylactic or therapeutic applications.

公开(公告)号：CA2623591A1

公开(公告)日：2007-03-22

申请号：CA2623591

申请日：2006-09-13

Applicant: BASF AG

Inventor： BOETTNER MEWES ,  REINDL ANDREAS ,  KNOELL ROLF ,  LANG CHRISTINE ,  VEEN MARKUS ,  BUDDE ECKHARD

IPC: C12N1/20 ,  A61K8/99 ,  A61Q15/00

Abstract: Described are microorganisms which are able to suppress the production of malodorous compounds by axillary bacteria. Also described are compositions comprising such microorganisms as well as the use of such micoorganisms in cosmetic, prophylactic or therapeutic applications.