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    GTP CYCLOHYDROLASE II AS A TARGET FOR FUNGICIDES
    1.
    发明申请
    GTP CYCLOHYDROLASE II AS A TARGET FOR FUNGICIDES 审中-公开
    GTP环糊精II作为防治目的药物

    公开(公告)号：WO2004022776A3

    公开(公告)日：2004-07-08

    申请号：PCT/EP0309369

    申请日：2003-08-23

    Applicant: BASF AG ,  FREUND ANNETTE ,  ROEHL FRANZ ,  ALTHOEFER HENNING ,  KAROS MARVIN ,  KAESLER BRUNO ,  LACOUR THIERRY

    Inventor： FREUND ANNETTE ,  ROEHL FRANZ ,  ALTHOEFER HENNING ,  KAROS MARVIN ,  KAESLER BRUNO ,  LACOUR THIERRY

    IPC: A01N43/90 ,  A01N61/00 ,  C12N9/78 ,  C12N15/04 ,  C12N15/52 ,  C12Q1/32 ,  C12Q1/34

    CPC classification number: A01N61/00 ,  A01N43/90 ,  C12N9/78 ,  C12Q1/34 ,  C12Y305/04025 ,  G01N2500/02

    Abstract: The present invention relates to inhibition of GTP cyclohydrolase II as target for the identification of fungicides. Binding assays are claimed and coupled enzymatic assays are disclosed involving the conversion of formate (product of the reaction catalyzed by GTP-cyclohydrolases) by formate dehydrogenase and spectroscopically measuring the NADH formed. Furthermore in vivo assays with organisms containing a GTP-cyclohydrolase II are claimed as well as a DNA sequence for a fungal GTP-cyclohydrolase II. 3-Butyl-10-(3-chlorophenyl)- 10H-pyrimido[4,5-b]quinoline-2,4-dione is identified by the enzymatic method as a fungicide. Finally, methods of controlling fungi (e.g. on plants, in soil) by applying this agent are claimed.

    Abstract translation: 本发明涉及抑制GTP环化水解酶II作为鉴定杀真菌剂的靶标。 公开了结合测定法，并公开了偶联的酶测定法，其涉及通过甲酸脱氢酶转化甲酸盐（由GTP-环化水解酶催化的反应产物）并光谱测量形成的NADH。 此外还要求具有含有GTP-环化水解酶II的生物体的体内测定以及用于真菌GTP-环化水解酶II的DNA序列。 通过酶法将3-丁基-10-（3-氯苯基）-10H-嘧啶并[4,5-b]喹啉-2,4-二酮鉴定为杀真菌剂。 最后，要求保护通过施用该试剂控制真菌（例如在土壤中的植物上）的方法。

    Means and methods for preventing and/or treating caries
    7.
    发明专利
    Means and methods for preventing and/or treating caries 未知

    公开(公告)号：AU2005281796A1

    公开(公告)日：2006-03-16

    申请号：AU2005281796

    申请日：2005-09-09

    Applicant: BASF AG

    Inventor： KNOLL ROLF ,  BUDDE ECKHARD ,  VEEN MARKUS ,  LANG CHRISTINE ,  BOETTNER MEWES ,  RYSER MARTIN ,  KAESLER BRUNO

    IPC: C12N1/20 ,  A23L13/60 ,  A23L15/00 ,  A23L17/00 ,  A23L27/60 ,  A23L29/00 ,  A61K35/74 ,  A61K35/747 ,  C12R1/225

    Abstract: The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention.

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