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    Means and methods for preventing and/or treating caries
    2.
    发明专利
    Means and methods for preventing and/or treating caries 未知

    公开(公告)号：AU2005281796A1

    公开(公告)日：2006-03-16

    申请号：AU2005281796

    申请日：2005-09-09

    Applicant: BASF AG

    Inventor： KNOLL ROLF ,  BUDDE ECKHARD ,  VEEN MARKUS ,  LANG CHRISTINE ,  BOETTNER MEWES ,  RYSER MARTIN ,  KAESLER BRUNO

    IPC: C12N1/20 ,  A23L13/60 ,  A23L15/00 ,  A23L17/00 ,  A23L27/60 ,  A23L29/00 ,  A61K35/74 ,  A61K35/747 ,  C12R1/225

    Abstract: The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention.

    3.
    发明专利
    未知

    公开(公告)号：DE10203352A1

    公开(公告)日：2003-07-31

    申请号：DE10203352

    申请日：2002-01-29

    Applicant: BASF AG

    Inventor： LANG CHRISTINE ,  VEEN MARKUS

    IPC: C12N1/19 ,  C12N9/02 ,  C12N9/90 ,  C12P33/00 ,  C12N15/62 ,  C12N15/52 ,  C12N15/81

    Abstract: The invention relates to a method for the production of 7-dehydrocholesterol and/or the biosynthetic intermediate or subsequent products thereof by the cultivation of organisms, in particular, yeasts which show an increased activity of at least one activity, selected from delta-8/delta-7 isomerisation activity, delta-5 desaturase activity or delta-24 reductase activity. The invention further relates to the nucleic acid constructs necessary for production of the genetically-modified organisms and the genetically-modified organisms, in particular, the yeasts themselves.

    Means and methods for preventing and/or treating caries
    4.
    发明专利
    Means and methods for preventing and/or treating caries 未知

    公开(公告)号：AU2005281796C1

    公开(公告)日：2014-01-23

    申请号：AU2005281796

    申请日：2005-09-09

    Applicant: BASF AG

    Inventor： KAESLER BRUNO ,  KNOELL ROLF ,  BOETTNER MEWES ,  BUDDE ECKHARD ,  LANG CHRISTINE ,  RYSER MARTIN ,  VEEN MARKUS

    IPC: C12N1/20 ,  A23L13/60 ,  A23L15/00 ,  A23L17/00 ,  A23L27/60 ,  A23L29/00 ,  A61K35/74 ,  A61K35/747 ,  C12R1/225

    Abstract: The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention.

    Means and methods for preventing and/or treating caries
    6.
    发明专利
    Means and methods for preventing and/or treating caries 未知

    公开(公告)号：AU2005281796B2

    公开(公告)日：2011-06-16

    申请号：AU2005281796

    申请日：2005-09-09

    Applicant: BASF AG

    Inventor： KNOLL ROLF ,  BUDDE ECKHARD ,  VEEN MARKUS ,  LANG CHRISTINE ,  BOETTNER MEWES ,  RYSER MARTIN ,  KAESLER BRUNO

    IPC: C12N1/20 ,  A23L13/60 ,  A23L15/00 ,  A23L17/00 ,  A23L27/60 ,  A23L29/00 ,  A61K35/74 ,  A61K35/747 ,  C12R1/225

    Abstract: The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention.

    9.
    发明专利
    未知

    公开(公告)号：DE10312314A1

    公开(公告)日：2004-09-30

    申请号：DE10312314

    申请日：2003-03-19

    Applicant: BASF AG

    Inventor： KUENKEL ANDREAS ,  VEEN MARKUS ,  LANG CHRISTINE

    IPC: C12P33/00 ,  C12N1/00

    Abstract: The present invention relates to a method for the production of ergosta-5,7-dienol and/or its biosynthetic intermediates and/or metabolites by culturing genetically modified organisms, and to the genetically modified organisms, in particular yeasts, themselves.

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