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公开(公告)号:JP2000191625A
公开(公告)日:2000-07-11
申请号:JP36247499
申请日:1999-12-21
Applicant: BASF AG
Inventor: KESSEL KNUT , KLUGE MICHAEL DR , GREINDL THOMAS DR , BOGENSTAETTER THOMAS DR , SCHERR GUENTER DR , RAULS MATTHIAS DR , VAN GELDER RICHARD
IPC: C07C277/08 , C07C279/14 , C07C303/22 , C07C309/15 , C07F9/38
Abstract: PROBLEM TO BE SOLVED: To readily obtain a guanidine derivative in a high purity, high yield and narrow particle size distribution by reacting O-alkyl isourea salt with a specific amine in the presence of a seed crystal of a guanidine derivative. SOLUTION: This guanidine derivative (A) is expressed by formula I [R1 is a 1-8C alkylene or a 5-10C bifunctional alicyclic group; R2 is H or a 1-8C alkyl; Z is COOR3, SO2R3 (R3 is H, an alkali metal or the like) or the like] and is obtained by reacting (B) an O-alkyl isourea salt of formula II (R5 is a 1-8C alkyl; X- is 1 equivalent of anion) with (C) an amine of formula III in the presence of (D) a seed crystal of a guanidine of formula I. Preferably, the reaction is performed in a reaction chamber in which the components B and C are continuously introduced and thereafter the crystal of the component D is continuously taken out.
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公开(公告)号:JP2001348331A
公开(公告)日:2001-12-18
申请号:JP2001105109
申请日:2001-04-03
Applicant: BASF AG
Inventor: BOGENSTAETTER THOMAS DR , SCHERR GUENTER DR , KESSEL KNUT , BREITENBACH JOERG DR , BERNDL GUNTHER
IPC: A61K9/20 , A61K31/198 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/38 , A61P3/02 , A61P21/00 , C08K5/29 , C08L101/00
Abstract: PROBLEM TO BE SOLVED: To produce a novel creatine containing solid administration by a melt calendering. SOLUTION: This creatine-containing solid administration form is produced by (a) preparing a mixture containing at least one of high-molecular weight binders having thermoplastic physiologically permissible water-solubility or water-swelling property, creatine and water of 1-20 mol based on 1 mol of creatine, (b) plasticizing this mixture at the softening point of the high-molecular weight binders or over this softening point and (c) molding the plasticized mixture to the administration form and cooling.
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公开(公告)号:JP2001181254A
公开(公告)日:2001-07-03
申请号:JP2000387369
申请日:2000-12-20
Applicant: BASF AG
Inventor: KESSEL KNUT , SCHERR GUENTER DR , BOGENSTAETTER THOMAS DR , ORSTEN STEFAN , FRANKE DIRK
IPC: C07C277/06 , C07C277/08 , C07C279/14
Abstract: PROBLEM TO BE SOLVED: To provide a method for providing creatine having purity as high as possible in a simple way. SOLUTION: A method for purifying creatine is to introduce creatine to be purified and not containing water of crystallization into a saturated aqueous solution of creatine monohydrate in such a way that the creatine not containing water of crystallization is dissolved under a hydrated condition, to precipitate the crystal of creatine monohydrate from the aqueous solution and to separate the above crystal from the aqueous solution.
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公开(公告)号:JP2000229936A
公开(公告)日:2000-08-22
申请号:JP2000031893
申请日:2000-02-09
Applicant: BASF AG
Inventor: KESSEL KNUT , KLUGE MICHAEL DR , BOGENSTAETTER THOMAS DR , SCHERR GUENTER DR
IPC: C07C277/02 , C07C277/08 , C07C279/14
Abstract: PROBLEM TO BE SOLVED: To easily and continuously produce a guanidine derivative in a high purity and in a high yield by continuously reacting a cyanamide derivative with an amine in the presence of the seed crystals of the guanidine derivative. SOLUTION: This method for producing a guanamide derivative of formula III (R5, R6 are each H or a 1-8C alkyl) comprises continuously reacting a cyanamide derivative of formula I [R5', R6' are each H, the equivalent of an alkali(ne earth) metal or a 1-8C alkyl] with an amine of formula II R1 is a 1-8C alkylene or a 5-10C divalent alicyclic group; R2 is H or a 1-8C alkyl, or R1 and R2 form a Z-substituted five or six-membered ring together with the N atom bound to R1 and R2; and Z is COOR3 [R3 is H or the equivalent of an alkali(ne earth) metal] or the like) (for example, an amino carboxylic acid, an amino sulfonic acid or an amino phosphoric acid) in the presence of the seed crystals of the formula III. The cyanamide derivative of formula I and the amine of formula II are preferably used in a molar ratio of 2:1 to 1:2, and the reaction is carried out at pH 8-12 in an aqueous medium.
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公开(公告)号:JP2000159742A
公开(公告)日:2000-06-13
申请号:JP33181799
申请日:1999-11-22
Applicant: BASF AG
Inventor: KLUGE MICHAEL DR , KESSEL KNUT , GREINDL THOMAS DR , BIEDERMANN NORBERT DR , SCHERR GUENTER DR , BOGENSTAETTER THOMAS DR
IPC: C07C273/18 , C07C273/00 , C07C275/70
Abstract: PROBLEM TO BE SOLVED: To obtain an O-alkyl isourea as an acid adduct salt in a high yield, if necessary, by dissolving and dispersing urea and an alkyl group donor in a diluent, followed by reacting them in a continuously operated reactor at a specific temperature. SOLUTION: An O-alkyl isourea shown by the formula (R1 is a 1-20C alkyl) is obtained as an acid adduct salt in a high yield, if necessary, by dissolving and dispersing (a) urea and (B) an alkyl group donor (e.g. dialkyl sulfate) in a diluent, followed by reacting them in a continuously operated reactor (e.g. continuously flowed column reactor and continuously stirred tank reactor) at 40-200 deg.C. It is preferable that an (A:B) molar ratio is (3:1)-(1:2). The diluent has a heat capacity which elevates the temperature of the reaction mixture maximally to 150 deg.oC or less upon performing a substantially adiabatic reaction by the heat of the reaction.
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公开(公告)号:JP2000086616A
公开(公告)日:2000-03-28
申请号:JP25454399
申请日:1999-09-08
Applicant: BASF AG
Inventor: KESSEL KNUT DR , SCHERR GUENTER DR , KLUGE MICHAEL DR , BIEDERMANN NORBERT DR , GREINDL THOMAS DR , BOGENSTAETTER THOMAS DR , HAEHNLEIN WOLFGANG DR
IPC: C07C279/14 , C07C277/02 , C07C277/08
Abstract: PROBLEM TO BE SOLVED: To provide a simple and practicable method for producing creatine or creatine monohydrate without requiring great expenditures for measuring techniques or regulating techniques in regulating the value of pH using an inorganic acid or an organic acid. SOLUTION: The value of pH is regulated with carbonic acid in the case of a method for producing creatine or creatine monohydrate comprising reacting sodium sarcosinate or potassium sarcosinate with cyanamide at 20-150 deg.C temperature and 7.0-14.0 value of pH.
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公开(公告)号:DK0985661T3
公开(公告)日:2002-03-25
申请号:DK99117237
申请日:1999-09-02
Applicant: BASF AG
Inventor: KESSEL KNUT DR , SCHERR GUENTER DR , KLUGE MICHAEL DR , BIEDERMANN NORBERT DR , GREINDL THOMAS DR , BOGENSTAETTER THOMAS DR , HAEHNLEIN WOLFGANG DR
IPC: C07C279/14 , C07C277/02 , C07C277/08
Abstract: Preparation of creatine or creatine monohydrate by reaction of sodium or potassium sarcosinate with cyanamide at 20-150 degrees C and pH 7.0 to 14.0, the pH value is obtained using carbonic acid.
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公开(公告)号:SI0985661T1
公开(公告)日:2002-04-30
申请号:SI9930024
申请日:1999-09-02
Applicant: BASF AG
Inventor: KESSEL KNUT DR , SCHERR GUENTER DR , KLUGE MICHAEL DR , BIEDERMANN NORBERT DR , GREINDL THOMAS DR , BOGENSTAETTER THOMAS DR , HAEHNLEIN WOLFGANG DR
IPC: C07C277/08 , C07C279/14
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公开(公告)号:DE19743015A1
公开(公告)日:1999-04-01
申请号:DE19743015
申请日:1997-09-29
Applicant: BASF AG
Inventor: OFTRING ALFRED DR , BOGENSTAETTER THOMAS DR , OTT CHRISTIAN DR
IPC: C07C27/02 , C07C29/09 , C07C29/128 , C07C29/48 , C07C31/20 , C07C67/05 , C07C69/08 , C07C31/18 , C07C29/74 , C07C69/04
Abstract: The invention relates to a method for producing vicinal diols or polyols from an organic reaction mixture containing formic acid esters of vicinal diols or polyols. The reaction mixture is treated with water without adding bases and thermally treated afterwards, whereby the formic acid esters are hydrolyzed, the aqueous formic acid is separated and the vicinal diols or polyols remain.
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