公开(公告)号：JPH11228392A

公开(公告)日：1999-08-24

申请号：JP34168698

申请日：1998-12-01

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN DR ,  BERNDL GUNTHER ,  ERNST ANDREAS ,  SANNER AXEL DR

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K47/32

Abstract: PROBLEM TO BE SOLVED: To obtain an administration form producible by melt extrusion, capable of rapidly releasing an action substance, by using a homopolymer and copolymer of N-vinylcaprolactam as a polymer binder. SOLUTION: A homopolymer of N-vinyl caprolactam or a copolymer containing preferably at least 10 wt.% of N-vinylcaprolactam unit by copolymerization as a polymer binder is formulated with at least one action substance and optionally an common additive. A plastic mixture is formed and molded to give the objective solid administration form.

公开(公告)号：JPH11322585A

公开(公告)日：1999-11-24

申请号：JP7868099

申请日：1999-03-23

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN DR ,  BERNDL GUNTHER ,  SIMON DIRK ,  SANNER AXEL DR

IPC: A23L33/00 ,  A61K9/20 ,  A61K9/22 ,  A61K47/32 ,  A61K47/34 ,  C08F279/02 ,  C08L51/04

Abstract: PROBLEM TO BE SOLVED: To produce the subject dosage form producible by melt extrusion and capable of slowly releasing an agent by using a water swellable graft copolymer as a high-molecular weight binder. SOLUTION: When (A) at least one kind of a high-molecular weight binder, (B) at least one kind of agent and, as necessary, (C) a usual additive are mixed and formed under the formation of a plastic mixture, a water swellable graft copolymer or a mixture thereof is used as the ingredient A. The amounts of the formulated ingredients A and B based on the total weight of the dosage form are preferably 10-100 wt.%, more preferably 40-99.9 wt.% of the ingredient A and preferably 0-90 wt.%, more preferably 0.1-60 wt.% of the ingredient B.

公开(公告)号：JP2001348331A

公开(公告)日：2001-12-18

申请号：JP2001105109

申请日：2001-04-03

Applicant: BASF AG

Inventor： BOGENSTAETTER THOMAS DR ,  SCHERR GUENTER DR ,  KESSEL KNUT ,  BREITENBACH JOERG DR ,  BERNDL GUNTHER

IPC: A61K9/20 ,  A61K31/198 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61P3/02 ,  A61P21/00 ,  C08K5/29 ,  C08L101/00

Abstract: PROBLEM TO BE SOLVED: To produce a novel creatine containing solid administration by a melt calendering. SOLUTION: This creatine-containing solid administration form is produced by (a) preparing a mixture containing at least one of high-molecular weight binders having thermoplastic physiologically permissible water-solubility or water-swelling property, creatine and water of 1-20 mol based on 1 mol of creatine, (b) plasticizing this mixture at the softening point of the high-molecular weight binders or over this softening point and (c) molding the plasticized mixture to the administration form and cooling.

公开(公告)号：JPH11269098A

公开(公告)日：1999-10-05

申请号：JP432299

申请日：1999-01-11

Applicant: BASF AG

Inventor： KOTHRADE STEPHAN DR ,  MUELLER WOLFGANG DR ,  BERNDL GUNTHER ,  SANNER AXEL DR

IPC: A23K1/16 ,  A61K9/20 ,  A61K9/22 ,  A61K47/34

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a solid dosage form by extruding a melted product containing a specific polyamide as a binder, capable of simply obtaining the dosage form having an active ingredient sustained release property at an advantageous cost. SOLUTION: This method for producing a dosage form comprises mixing (A) at least one of polymer binder, if necessary, with (B) at least one kind of active ingredient and, if necessary, further with (C) one or more kinds of conventional additives and subsequently molding the formed plastic mixture. Therein, a polyamide having sulfonate groups is used as the component A. The polyamide is preferably obtained from (i) 0-90 mol.% of at least one kind of monoaminocarboxylic acid, its lactam or a mixture of the monoaminocarboxylic acid with its lactam, (ii) 5-50 mol.% of at least one kind of a primary or secondary diamine and (iii) 0.5-49.5 mol.% of at least one kind of sulfonate group-having dicarboxylic acid.

公开(公告)号：JP2001158733A

公开(公告)日：2001-06-12

申请号：JP2000273706

申请日：2000-09-08

Applicant: BASF AG

Inventor： ERNST ANDREAS ,  KESSLER THOMAS ,  BERNDL GUNTHER

IPC: A01N25/10 ,  A01N25/12 ,  A23K40/10 ,  A23K40/20 ,  A23L33/15 ,  A23L33/155 ,  A23P1/02 ,  A61J3/00 ,  A61K9/16 ,  A61K9/19 ,  A61K47/32 ,  B01J2/20 ,  B29B9/06 ,  C08J3/205 ,  A23L1/302

Abstract: PROBLEM TO BE SOLVED: To develop a method for inexpensively and simply preparing a functional substance-containing preparation which is dissolved or itself dispersed in water or in gastrointestinal tracts, such as medicines or food additives. SOLUTION: This method for preparing granules which contain a biologically active substance and in which the biologically active substance is homogeneously dispersed in a matrix based on at least one thermoplastic polymer having a solubility dependent to pH values in an aqueous medium, by homogeneously mixing the charged substance in the state of the melt and then extruding and shaping the mixture, characterized by forming the granules in an insoluble or nondispersible cooling medium.

公开(公告)号：JPH11310618A

公开(公告)日：1999-11-09

申请号：JP7240899

申请日：1999-03-17

Applicant: BASF AG

Inventor： MEFFERT HELMUT DR ,  SANNER AXEL DR ,  BERNDL GUNTHER ,  RUCHATZ FOLKER DR ,  KOLTER KARL DR ,  BAUER KURT HEINZ

IPC: A61K8/63 ,  A61K9/00 ,  A61K9/107 ,  A61K9/20 ,  A61K9/48 ,  A61K47/32 ,  C08F220/04 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain a solubilizing agent having a sufficient solubility and high solubilizing activities in water, and capable of being applied to medicines, cosmetics and foods. SOLUTION: This use is the one of copolymers comprising (a) 82-99.9 mol.% of at least one monoethylenically unsaturated a 3-8C carboxylic acid, (b) 0.1-18 mol.% of at least one monomer selected from the group of (b1 ) N-(8-30C alkyl)- substituted amides of monoethylenically unsaturated 3-8C carboxylic acids, (b2 ) N,N-(8-30C dialkyl)-substituted amides of monoethylenically unsaturated 3-8C carboxylic acids and (b3 ) 8-30C alkyl esters of monoethylenically unsaturated 3-8C carboxylic acids, and (c) 0-17.9 mol.% of at least one monomer selected from the group of (c1 ) vinyl esters of aliphatic 8-30C carboxylic acids and (c2 ) 8-30C alkylvinyl ethers, in which the mol.% data for the individual components adding up to 100%, as a solubilizer.

公开(公告)号：WO0064414A3

公开(公告)日：2001-05-31

申请号：PCT/EP0003232

申请日：2000-04-11

Applicant: BASF AG ,  HEGER ROBERT ,  SCHROF WOLFGANG ,  RIEGER JENS ,  VOELKEL RUEDIGER ,  BREITENBACH JOERG ,  ZEIDLER JUERGEN ,  LIEPOLD BERND ,  BERNDL GUNTHER ,  BINDER RUDOLF

Inventor： HEGER ROBERT ,  SCHROF WOLFGANG ,  RIEGER JENS ,  VOELKEL RUEDIGER ,  BREITENBACH JOERG ,  ZEIDLER JUERGEN ,  LIEPOLD BERND ,  BERNDL GUNTHER ,  BINDER RUDOLF

IPC: A61K47/22 ,  A61K9/16 ,  A61K31/4184 ,  A61K31/4439 ,  A61K45/00 ,  A61K47/34 ,  A61K47/42 ,  A61P1/00 ,  A61P1/04 ,  A61P35/00

CPC classification number: A61K9/1617 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1658 ,  A61K31/4184 ,  A61K31/4439

Abstract: The invention relates to a solid preparation, containing an acid-sensitive proton-pump blocker as the active substance, whereby said active substance is present in an x-ray amorphous form and is embedded in molecularly dispersed form in an auxiliary agent matrix.

Abstract translation: 含有固体制剂，作为活性物质可使用酸不稳定的质子泵抑制剂，其特征在于所述活性物质是X射线无定形并且被嵌入在分子中的赋形剂基质中。

公开(公告)号：WO9944588A3

公开(公告)日：1999-10-28

申请号：PCT/EP9901271

申请日：1999-02-26

Applicant: BASF AG ,  KLEINKE ANDREAS ,  KESSLER THOMAS ,  ROSENBERG JOERG ,  KRULL HARALD ,  BERNDL GUNTHER ,  MAIER WERNER ,  BREITENBACH JOERG

Inventor： KLEINKE ANDREAS ,  KESSLER THOMAS ,  ROSENBERG JOERG ,  KRULL HARALD ,  BERNDL GUNTHER ,  MAIER WERNER ,  BREITENBACH JOERG

IPC: A61K9/16 ,  A61K31/135 ,  A61K31/192

CPC classification number: A61K31/192 ,  A61K9/1623 ,  A61K9/1694 ,  A61K31/135

Abstract: The invention relates to a method for producing solid, spherical forms containing at least one pharmaceutical active agent homogeneously dispersed in an auxiliary matrix. According to this method, the constituents are mixed to form a melt which is then shaped. The invention is characterised in that at least one pharmaceutical active agent is processed with at least one thermoplastically processable matrix auxiliary to form a homogeneous melt with a viscosity of less than 5000 mPas and in that this melt is shaped into drops using a rotating perforated roll. These drops are then cooled so that they solidify.

Abstract translation: 一种用于制备包含至少实心球形成型体的过程中的赋形剂基质均匀地分散在一种药物活性成分，通过将成分混合到熔融和随后的成形，其特征在于，至少一种活性药物成分与至少一种热塑性加工的矩阵佐剂均匀熔体 用粘度加工小于5000毫帕·秒，和成形用旋转穿孔辊的帮助下到其随后通过冷却固化滴熔体中。

公开(公告)号：WO0191727A3

公开(公告)日：2002-05-10

申请号：PCT/EP0106116

申请日：2001-05-29

Applicant: BASF AG ,  BERNDL GUNTHER ,  BREITENBACH JOERG ,  HEGER ROBERT ,  STADLER MICHAEL ,  WILKE PETER ,  ROSENBERG JOERG

Inventor： BERNDL GUNTHER ,  BREITENBACH JOERG ,  HEGER ROBERT ,  STADLER MICHAEL ,  WILKE PETER ,  ROSENBERG JOERG

IPC: A61F13/53 ,  A23P1/02 ,  A23P1/08 ,  A61F13/49 ,  A61K9/107 ,  A61K9/16 ,  A61K47/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

CPC classification number: A61K9/107 ,  A61K9/1075 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1652 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  B29C47/0011 ,  B29C47/8895

Abstract: The invention relates to self-emulsifying formulations based on an active substance constituent and on a formulation base with a lipid constituent and with a binding agent constituent. The invention also relates to the use of this formulation as a dosed form in the area of life science. The invention also relates to a method for producing self-emulsifying formulations by mixing the formulation constituents while forming a plastic mixture and optionally while preparing the formulations as a dosed form, advantageously while using melt extrusion. The formulations spontaneously form emulsions in water or in aqueous fluids.

Abstract translation: 本发明涉及基于一种药物成分和与脂质成分和粘合剂成分，以及使用该制剂的如在生命科学领域的剂型的制剂底座上自乳化制剂。 本发明还描述了通过混合制剂组分以形成一个塑料混合物制备的自乳化制剂的方法，和任选的嵌合时的制剂的作为剂型，有利地使用熔融挤出。 在水或含水液体，所述制剂自发形成乳液。

公开(公告)号：WO0130372A2

公开(公告)日：2001-05-03

申请号：PCT/EP0010205

申请日：2000-10-17

Applicant: BASF AG ,  HEGER ROBERT ,  BREITENBACH JOERG ,  BERNDL GUNTHER ,  BINDER RUDOLF

Inventor： HEGER ROBERT ,  BREITENBACH JOERG ,  BERNDL GUNTHER ,  BINDER RUDOLF

IPC: A61K9/14 ,  A61K9/50 ,  A61K9/51 ,  A61K38/00 ,  A61K38/13 ,  A61K9/20

CPC classification number: A61K9/5138 ,  A61K9/5084 ,  A61K9/5146

Abstract: The invention relates to solid pharmaceutical galenic forms comprising an agent in the form of a physical mixture of two different preparations with regard to the physical state of the agent.

Abstract translation: 本发明涉及包含至少两种不同的物理混合物的形式的活性成分相对于所述药物制剂的物理状态的固体药物剂型。