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公开(公告)号:JPH11222476A
公开(公告)日:1999-08-17
申请号:JP31219498
申请日:1998-11-02
Applicant: BASF AG
Inventor: GREINDL THOMAS DR , SCHERR GUENTER DR , SCHNEIDER ROLF , MUNDINGER KLAUS DR
IPC: C07C277/02 , C07C275/70 , C07C277/08 , C07C279/04 , C07C279/08 , C07C279/12 , C07C279/14 , C07C279/16 , C07C303/30 , C07C303/40 , C07C309/76 , C07C311/05 , C08G65/333 , C08G65/337 , C08G65/338 , C08G73/02
Abstract: PROBLEM TO BE SOLVED: To provide a method for simply and inexpensively producing the subject compound in high yield useful as e.g. an energy carrier of cells for supply of nutrition in food and drug fields by reacting a specific haloformamidinium salt with a specific amine. SOLUTION: This compound (e.g. creatine) of formula III is obtained by reacting (A) a haloformamidinium salt (pref. chloroformamidinium chloride) of formula I (Hal is e.g. Cl or F) with a primary or secondary amine (e.g. Na- sarcosinate) of formula II (e.g. R is e.g. H or an 1-20C alkyl; and R is e.g. an 1-20C alkyl or 2-20C alkenyl) in a solvent e.g. water pref. at pH 8 to 12 at 20 to 70 deg.C. A reactive component A is pref. dropped into a component B for 1 to 3 hrs. and then the resultant mixture is pref. stirred for 1 to 3 hrs.
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公开(公告)号:JPH1060263A
公开(公告)日:1998-03-03
申请号:JP12513097
申请日:1997-05-15
Applicant: BASF AG
Inventor: LICHT ULRIKE DR , KOKEL NICOLAS DR , HAEBERLE KARL DR , ANGEL MAXIMILIAN DR , WEYLAND PETER DR , SCHERR GUENTER DR
IPC: C08L75/14 , C08G18/08 , C08G18/67 , C08G73/04 , C09D175/14 , C09J175/14
Abstract: PROBLEM TO BE SOLVED: To obtain the subject dispersant which has a good storage stability and is used for forming a thermally stable bond by formulating a specific polyurethane and an amino-functional group-bearing macromolecular compound. SOLUTION: This dispersant contains (A) a mixture of (i) a polyurethane bearing a group which makes the polyurethane dispersible in water and a C-C double bond which is activated by the directly bonding carbonyl group, (ii) a polyurethane which makes the polyurethane dispersible in water, but does not bear the group bearing a C-C double bond activated by the directly bonding carbonyl group and (B) a compound which bears at least two of hydrogen bonds in the from of an amino functional group, has a solubility of >=1g/l (at 25 deg.C) and a number-average molecular weight (Mn ) of 200-1,000,000. Thus, a dispersant useful as a coating or an adhesive is obtained.
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公开(公告)号:JP2002363161A
公开(公告)日:2002-12-18
申请号:JP2002131389
申请日:2002-05-07
Applicant: BASF AG
Inventor: LUNKWITZ RALPH , PABST GUNTHER , SCHERR GUENTER DR
IPC: C07D401/14 , C07D213/50 , C07D213/61 , C07D213/68 , C07D213/803
Abstract: PROBLEM TO BE SOLVED: To provide a method for producing terpyridine from 2-cyanopyridine on an industrial scale. SOLUTION: Terpyridine is produced by a method containing a successive reaction process comprising (A) the condensation of a (1-4C alkyl)pyridine-2- carboxylate derivative and acetone in an aprotic solvent in the presence of a base, (B) the reaction of the obtained 1,5-bis(2-pyridyl)pentane-1,3,5-trione derivative with ammonia or an ammonium salt of the formula: (NH4 )q Y while removing produced water from the system and (C) the chlorination of the obtained 2,6-bis(2-pyridyl)-4(1H)pyridinone derivative.
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公开(公告)号:JP2000191625A
公开(公告)日:2000-07-11
申请号:JP36247499
申请日:1999-12-21
Applicant: BASF AG
Inventor: KESSEL KNUT , KLUGE MICHAEL DR , GREINDL THOMAS DR , BOGENSTAETTER THOMAS DR , SCHERR GUENTER DR , RAULS MATTHIAS DR , VAN GELDER RICHARD
IPC: C07C277/08 , C07C279/14 , C07C303/22 , C07C309/15 , C07F9/38
Abstract: PROBLEM TO BE SOLVED: To readily obtain a guanidine derivative in a high purity, high yield and narrow particle size distribution by reacting O-alkyl isourea salt with a specific amine in the presence of a seed crystal of a guanidine derivative. SOLUTION: This guanidine derivative (A) is expressed by formula I [R1 is a 1-8C alkylene or a 5-10C bifunctional alicyclic group; R2 is H or a 1-8C alkyl; Z is COOR3, SO2R3 (R3 is H, an alkali metal or the like) or the like] and is obtained by reacting (B) an O-alkyl isourea salt of formula II (R5 is a 1-8C alkyl; X- is 1 equivalent of anion) with (C) an amine of formula III in the presence of (D) a seed crystal of a guanidine of formula I. Preferably, the reaction is performed in a reaction chamber in which the components B and C are continuously introduced and thereafter the crystal of the component D is continuously taken out.
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公开(公告)号:JPH11222477A
公开(公告)日:1999-08-17
申请号:JP31219698
申请日:1998-11-02
Applicant: BASF AG
Inventor: GREINDL THOMAS DR , SCHERR GUENTER DR , SCHNEIDER ROLF , MUNDINGER KLAUS DR
IPC: C07C277/00 , C07C277/08 , C07C279/04 , C07C279/08 , C07C279/12 , C07C279/14 , C07C279/16 , C07C303/30 , C07C303/40 , C07C309/76 , C07C311/05 , C08G65/333 , C08G73/02
Abstract: PROBLEM TO BE SOLVED: To provide a method for simply and inexpensively producing the subject compound in high yield useful as e.g. an energy carrier of cells for supply of nutrition in food and drug fields by subjecting an urea to a reaction so as to form a specific alkylated isourea and reacting it with a specific amine. SOLUTION: This compound (e.g. creatine) of formula III is obtained by reacting an urea with a dialkyl sulfate (e.g. dimethyl sulfate) of the formula, (R )2 O-SO2 (R is an 1-20C alkyl) at -20 to 90 deg.C so as to form an alkylated isourea (e.g. O-methyl isourea) and reacting it with a primary or secondary amine (e.g. Na-sarcosinate) of formula II (e.g. R is e.g. H or an 1-20C alkyl; and R is e.g. an 1-20C alkyl or 2-20C alkenyl) in a solvent e.g. water pref. at pH 9 to 11.5 at 10 to 60 deg.C.
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公开(公告)号:JPH11209335A
公开(公告)日:1999-08-03
申请号:JP31219798
申请日:1998-11-02
Applicant: BASF AG
Inventor: GREINDL THOMAS DR , SCHERR GUENTER DR , SCHNEIDER ROLF , MUNDINGER KLAUS DR
IPC: C07C277/02 , C07C277/08 , C07C279/14 , C07C303/22 , C07C303/30 , C07C303/40 , C07C309/15 , C07C309/69 , C07C311/47
Abstract: PROBLEM TO BE SOLVED: To obtain the subject high-purity compound simply in a high yield by using readily obtainable starting raw materials, by reacting calcium cyanamide with a primary or a secondary aminocarboxylic acid. SOLUTION: Calcium cyanamide is reacted with a primary or a secondary aminocarboxylic acid alcohol of the formula I [R is H or a 1-20C alkyl; R is a (1-20C alkylene)-COOR , a (1-20C alkylene)-CONR R (R is H, a 3-8C cycloalkyl or the like; R and R are each H, a 6-18C aryl or the like) or the like], a primary or a secondary aminosulfonic acid or their derivative to give the objective compound of formula II. Preferably the reaction is carried out in water and/or an organic solvent mixable with water at 40-80 deg.C at pH 9-11. Preferably calcium cyanamide is economically used in the form of industrial lime nitrogen containing 30-95 wt.% of calcium cyanamide. Sarcosine sodium or potassium salt is preferable as the compound of formula I or its derivative.
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公开(公告)号:JP2000229936A
公开(公告)日:2000-08-22
申请号:JP2000031893
申请日:2000-02-09
Applicant: BASF AG
Inventor: KESSEL KNUT , KLUGE MICHAEL DR , BOGENSTAETTER THOMAS DR , SCHERR GUENTER DR
IPC: C07C277/02 , C07C277/08 , C07C279/14
Abstract: PROBLEM TO BE SOLVED: To easily and continuously produce a guanidine derivative in a high purity and in a high yield by continuously reacting a cyanamide derivative with an amine in the presence of the seed crystals of the guanidine derivative. SOLUTION: This method for producing a guanamide derivative of formula III (R5, R6 are each H or a 1-8C alkyl) comprises continuously reacting a cyanamide derivative of formula I [R5', R6' are each H, the equivalent of an alkali(ne earth) metal or a 1-8C alkyl] with an amine of formula II R1 is a 1-8C alkylene or a 5-10C divalent alicyclic group; R2 is H or a 1-8C alkyl, or R1 and R2 form a Z-substituted five or six-membered ring together with the N atom bound to R1 and R2; and Z is COOR3 [R3 is H or the equivalent of an alkali(ne earth) metal] or the like) (for example, an amino carboxylic acid, an amino sulfonic acid or an amino phosphoric acid) in the presence of the seed crystals of the formula III. The cyanamide derivative of formula I and the amine of formula II are preferably used in a molar ratio of 2:1 to 1:2, and the reaction is carried out at pH 8-12 in an aqueous medium.
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公开(公告)号:JP2000159742A
公开(公告)日:2000-06-13
申请号:JP33181799
申请日:1999-11-22
Applicant: BASF AG
Inventor: KLUGE MICHAEL DR , KESSEL KNUT , GREINDL THOMAS DR , BIEDERMANN NORBERT DR , SCHERR GUENTER DR , BOGENSTAETTER THOMAS DR
IPC: C07C273/18 , C07C273/00 , C07C275/70
Abstract: PROBLEM TO BE SOLVED: To obtain an O-alkyl isourea as an acid adduct salt in a high yield, if necessary, by dissolving and dispersing urea and an alkyl group donor in a diluent, followed by reacting them in a continuously operated reactor at a specific temperature. SOLUTION: An O-alkyl isourea shown by the formula (R1 is a 1-20C alkyl) is obtained as an acid adduct salt in a high yield, if necessary, by dissolving and dispersing (a) urea and (B) an alkyl group donor (e.g. dialkyl sulfate) in a diluent, followed by reacting them in a continuously operated reactor (e.g. continuously flowed column reactor and continuously stirred tank reactor) at 40-200 deg.C. It is preferable that an (A:B) molar ratio is (3:1)-(1:2). The diluent has a heat capacity which elevates the temperature of the reaction mixture maximally to 150 deg.oC or less upon performing a substantially adiabatic reaction by the heat of the reaction.
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公开(公告)号:JP2000086616A
公开(公告)日:2000-03-28
申请号:JP25454399
申请日:1999-09-08
Applicant: BASF AG
Inventor: KESSEL KNUT DR , SCHERR GUENTER DR , KLUGE MICHAEL DR , BIEDERMANN NORBERT DR , GREINDL THOMAS DR , BOGENSTAETTER THOMAS DR , HAEHNLEIN WOLFGANG DR
IPC: C07C279/14 , C07C277/02 , C07C277/08
Abstract: PROBLEM TO BE SOLVED: To provide a simple and practicable method for producing creatine or creatine monohydrate without requiring great expenditures for measuring techniques or regulating techniques in regulating the value of pH using an inorganic acid or an organic acid. SOLUTION: The value of pH is regulated with carbonic acid in the case of a method for producing creatine or creatine monohydrate comprising reacting sodium sarcosinate or potassium sarcosinate with cyanamide at 20-150 deg.C temperature and 7.0-14.0 value of pH.
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公开(公告)号:JP2001348331A
公开(公告)日:2001-12-18
申请号:JP2001105109
申请日:2001-04-03
Applicant: BASF AG
Inventor: BOGENSTAETTER THOMAS DR , SCHERR GUENTER DR , KESSEL KNUT , BREITENBACH JOERG DR , BERNDL GUNTHER
IPC: A61K9/20 , A61K31/198 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/38 , A61P3/02 , A61P21/00 , C08K5/29 , C08L101/00
Abstract: PROBLEM TO BE SOLVED: To produce a novel creatine containing solid administration by a melt calendering. SOLUTION: This creatine-containing solid administration form is produced by (a) preparing a mixture containing at least one of high-molecular weight binders having thermoplastic physiologically permissible water-solubility or water-swelling property, creatine and water of 1-20 mol based on 1 mol of creatine, (b) plasticizing this mixture at the softening point of the high-molecular weight binders or over this softening point and (c) molding the plasticized mixture to the administration form and cooling.
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