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公开(公告)号:HU0104010A2
公开(公告)日:2002-03-28
申请号:HU0104010
申请日:1999-10-16
Applicant: BASF AG
Inventor: BERNARD HARALD , DR RIECHERS HARTMUT
Abstract: A process for racemate resolution of 2-hydroxypropionic acids by reacting the racemic acid with an optically active base and subsequently separating off a diastereomeric salt of acid and base comprises using 1-(4-chlorophenyl)ethylamine as optically active base.
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公开(公告)号:HU0000553A2
公开(公告)日:2001-04-28
申请号:HU0000553
申请日:1997-12-04
Applicant: BASF AG
Inventor: AMBERG WILHELM , HERGENROEDER STEFAN , JANSEN ROLF , DR KLING ANDREAS , DR KLINGE DAGMAR , DR RASCHACK MANFRED , DR RIECHERS HARTMUT , DR UNGER LILIANE
IPC: C07D253/06 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/53 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , C07D237/14 , C07D237/16 , C07D241/18 , C07D253/07 , C07D253/075 , C07D253/10 , C07D403/12 , C07D491/04
Abstract: The present invention relates to carboxylic acid derivatives of the formula Iwhere the substituents have the meanings explained in the description, and to preparation and use as endothelin receptor antagonists.
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3.
公开(公告)号:HU220621B1
公开(公告)日:2002-03-28
申请号:HU9701975
申请日:1995-10-07
Applicant: BASF AG
Inventor: DR AMBERG WILHELM , DR BAUMANN ERNST , DR KLING ANDREAS , DR KLINGE DAGMAR , DR MUELLER STEFAN , DR RASCHACK MANFRED , DR RHEINHEIMER JOACHIM , DR RIECHERS HARTMUT , DR UNGER LILIANE , DR VOGELBACHER UWE JOSEF , DR WERNET WOLFGANG
IPC: C07D251/30 , A61K31/505 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , C07D239/00 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/12 , C07D251/52 , C07D257/02 , C07D309/00 , C07D403/06 , C07D403/12 , C07D405/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048
Abstract: Heterocyclyl-substd. propanoic acids and their derivs., of formula (I), are new. R = formyl, tetrazolyl, nitrile, COOH or a gp. that can be hydrolysed to COOH; X = N or CR14; R2 = H, OH, NH2, alkylamino, dialkylamino, halo, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; R14 = H or 1-5 C alkyl; R3 = R2 or alkoxyimino; or CR3 + CR14 = 5 or 6 membered alkylene or alkenyl ring (opt. substd. by 1-2 alkyl) in which a methylene can be replaced by O, S, NH or alkylamino; R4, R5 = phenyl or naphthyl (both opt. substd. by one or more halo, NO2, CN, OH, alkyl, haloalkyl, alkoxy, haloalkyloxy, phenoxy, alkylthio, NH2, alkylamine or dialkylamino) or 3-7 C cycloalkyl; or the phenyl or naphthyl gps. are opt. bonded at the O- position (by a bond, CH2, O, S, SO2, ethylene, ethenylene or opt. alkylated amino); R6 = H, 1-8 C alkyl, 2-6 C alkenyl, 3-6 C alkynyl, 3-8 C cycloalkyl (all opt. substd. by 1 or more halo, NO2, CN, alkoxy 3-6 C alkenyloxy, 3-6 C alkynyloxy, alkylthio, haloalkoxy, alkylcarbonyl, alkoxycarbonyl, 3-8 C alkylcarbonylalkyl, alkylamino, dialkylamino, phenyl, Ph or OPh), Ar or Het; Y = S, O or bond; Q = S, O, SO, SO2 or bond; Ph = substd. phenyl, where substits. are halo, NO2, CN, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; Ar = phenyl or naphthyl (both opt. substd. by 1 or more halo, NO2, CN, OH, NH2, alkylamino, dialkylamino or OCH2CH2O); Het = 5 or 6 membered heteroaromatic with 1-3 N atoms and/or one S or O (opt. substd. by 1-4 halo and/or 1 or 2 alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, phenyl, phenoxy or phenyl carbonyl (where the phenyl is opt. substd. by 1-5 halo and/or 1-3 alkyl, haloalkyl, alkoxy, haloalkoxy and/or alkylthio)); alkyl and alkoxy have 1-4 C unless otherwise stated; provided that R6 is not H when Q = bond.
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公开(公告)号:HU0004935A2
公开(公告)日:2001-10-28
申请号:HU0004935
申请日:1998-08-24
Applicant: BASF AG
Inventor: AMBERG WILHELM , HERGENROEDER STEFAN , JANSEN ROLF , DR KLINGE DAGMAR , RASCHACK MANFRED , DR RIECHERS HARTMUT , UNGER LILIANE
IPC: A61K31/421 , A61K31/426 , A61K31/428 , A61K31/496 , A61K31/505 , A61P9/10 , A61P9/12 , A61P43/00 , C07D239/34 , C07D239/52 , C07D263/38 , C07D277/20 , C07D277/34 , C07D277/68 , C07D409/12 , C07D239/04
Abstract: The invention relates to carboxylic acid derivatives of formula (I) wherein the radicals are defined in the description, and to the use of these derivatives as ETA/ETB endothelin-receptor antagonists.
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公开(公告)号:HU0000664A2
公开(公告)日:2001-04-28
申请号:HU0000664
申请日:1997-09-02
Applicant: BASF AG
Inventor: AMBERG WILHELM , HERGENROEDER STEFAN , JANSEN ROLF , DR KLING ANDREAS , DR KLINGE DAGMAR , RASCHACK MANFRED , DR RIECHERS HARTMUT , DR UNGER LILIANE
IPC: A61K31/505 , A61K31/506 , A61K31/519 , A61P9/04 , A61P9/08 , A61P9/12 , A61P43/00 , C07C59/66 , C07C69/734 , C07D239/34 , C07D239/52 , C07D239/60 , C07D239/70 , C07D491/04 , C07D491/048
Abstract: The invention relates to carboxylic acid derivatives of the formula Iwhere the radicals have the meanings stated in the description, and to their use as drugs.
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