公开(公告)号：DE3841759A1

公开(公告)日：1990-06-13

申请号：DE3841759

申请日：1988-12-12

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM DR ,  DAUM LOTHAR DR ,  HAUPT ANDREAS DR ,  SCHMIED BERNHARD DR ,  WALKER NIGEL DR ,  ZECHEL JOHANN-CHRISTIAN DR

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  C07K1/04 ,  C07K7/06 ,  C07K7/08 ,  C07K7/56 ,  C07K7/64 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525

Abstract: New peptides of formula X-A-Y, in which A, X and Y have the meanings given in the description, are useful therapeutic agents. A process for producing them is also described.

公开(公告)号：DE3841763A1

公开(公告)日：1990-06-13

申请号：DE3841763

申请日：1988-12-12

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM DR ,  DAUM LOTHAR DR ,  HAUPT ANDREAS DR ,  SCHMIED BERNHARD DR ,  WALKER NIGEL DR ,  ZECHEL JOHANN-CHRISTIAN DR

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  C07K1/04 ,  C07K7/06 ,  C07K7/08 ,  C07K7/64 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525

Abstract: New peptides of formula: X-Pro-A-B-Y, in which A, B, X and Y have the meanings given in the description, are useful therapeutic agents. A process for producing them is also described.

公开(公告)号：DE3841761A1

公开(公告)日：1990-06-13

申请号：DE3841761

申请日：1988-12-12

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM DR ,  DAUM LOTHAR DR ,  SCHMIED BERNHARD DR ,  WALKER NIGEL DR ,  ZECHEL JOHANN-CHRISTIAN DR ,  HAUPT ANDREAS DR

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  C07K1/04 ,  C07K7/06 ,  C07K7/08 ,  C07K7/64 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525

Abstract: New peptides of formula X-A-B-Tyr-Y, in which A, B, X and Y have the meanings given in the description, are useful therapeutic agents. A process for producing then is also described.

公开(公告)号：DE3841755A1

公开(公告)日：1990-06-13

申请号：DE3841755

申请日：1988-12-12

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM DR ,  DAUM LOTHAR DR ,  HAUPT ANDREAS DR ,  SCHMIED BERNHARD DR ,  WALKER NIGEL DR ,  ZECHEL JOHANN-CHRISTIAN DR

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  C07K1/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525

Abstract: New peptides of formula x-Ala-His-A-Y, in which A, X and Y have the meanings given in the description, are useful therapeutic agents. A process for producing them is also described.

公开(公告)号：DE3841754A1

公开(公告)日：1990-06-13

申请号：DE3841754

申请日：1988-12-12

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM DR ,  DAUM LOTHAR DR ,  HAUPT ANDREAS DR ,  SCHMIED BERNHARD DR ,  WALKER NIGEL DR ,  ZECHEL JOHANN-CHRISTIAN DR

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  C07K1/04 ,  C07K7/06 ,  C07K7/08 ,  C07K7/64 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525

Abstract: New peptides of formula X-A-Y, in which A, X and Y have the meanings given in the description, are useful therapeutic agents. A process for producing them is also described.

公开(公告)号：DE19745146A1

公开(公告)日：1999-04-15

申请号：DE19745146

申请日：1997-10-14

Applicant: BASF AG

Inventor： PUHL MICHAEL DR ,  ZECHEL JOHANN-CHRISTIAN DR ,  DITRICH KLAUS DR ,  HILLEN HEINZ DR ,  KOHL TANJA ,  ERHARDT MELANIE ,  HERGENROEDER STEFAN DR ,  MARKERT CLAUS OTTO DR

IPC: C07D333/40 ,  A61K31/198 ,  A61K31/27 ,  A61K31/381 ,  A61K31/4704 ,  A61K31/498 ,  A61P1/04 ,  A61P1/18 ,  A61P7/02 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P25/06 ,  A61P35/00 ,  C07C271/12 ,  C07C271/20 ,  C07C323/56 ,  C07D215/48 ,  C07D241/44 ,  C07D333/38 ,  A61K31/495 ,  A61K31/47 ,  A61K31/165 ,  A61K38/55 ,  C07D409/12

Abstract: N-Acyl N-(2-acylaminoethyl) alpha -amino acids of formula (I) and their salts are new. R1, R2 = optionally substituted 1-8C alkyl, aryl(1-8C)alkyl, heteroaryl(1-8C)alkyl, aryl or heteroaryl; R3 = group of formula (a), (b) or (c); X = O or CH2; Y = H or acetyl; Z = CH or N; R4 = optionally substituted 4-14C aryl (sic) or 4-14C heteroaryl having one or more rings containing one or more of O, S and N; and R5 = 1-8C alkyl, aryl(1-8C)alkyl, aryl or heteroaryl.

公开(公告)号：DE3939797A1

公开(公告)日：1991-06-06

申请号：DE3939797

申请日：1989-12-01

Applicant: BASF AG

Inventor： ZECHEL JOHANN-CHRISTIAN DR ,  SCHULT SABINE DR ,  UNGER LILIANE DR

IPC: A61K38/00 ,  C07K14/575

Abstract: The description relates to peptides of the formula: Z-Ak-Bl-Cm-Dn-Eo-Fp-Gq-H-Thr-I-Gln-J-K-NH2, where A - K, Z and k - q have the meaning given in the description, and their production. The peptides are suitable for combatting diseases.

公开(公告)号：DE3841768A1

公开(公告)日：1990-06-13

申请号：DE3841768

申请日：1988-12-12

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM DR ,  DAUM LOTHAR DR ,  HAUPT ANDREAS DR ,  SCHMIED BERNHARD DR ,  WALKER NIGEL DR ,  ZECHEL JOHANN-CHRISTIAN DR

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  C07K1/04 ,  C07K7/06 ,  C07K7/08 ,  C07K7/56 ,  C07K7/64 ,  C07K14/52 ,  C07K14/525

Abstract: New peptides of formula X-A-Gly-B-Y, in which A, B, X and Y have the meanings given in the description, are useful therapeutic agents. A process for producing them is also described.

公开(公告)号：DE3841753A1

公开(公告)日：1990-06-13

申请号：DE3841753

申请日：1988-12-12

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM DR ,  DAUM LOTHAR DR ,  HAUPT ANDREAS DR ,  SCHMIED BERNHARD DR ,  WALKER NIGEL DR ,  ZECHEL JOHANN-CHRISTIAN DR

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  C07K1/04 ,  C07K7/06 ,  C07K7/08 ,  C07K7/64 ,  C07K14/52 ,  C07K14/525

Abstract: Peptides derived from TNF, of formula (I): X-A-Gly-Asp-Y, in which A X and Y have the meanings given in the description. Process for producing them. The novel peptides are useful therapeutic agents.

公开(公告)号：DE4313232A1

公开(公告)日：1994-10-27

申请号：DE4313232

申请日：1993-04-22

Applicant: BASF AG

Inventor： ECKARD PETER ,  HILLEN HEINZ DR ,  OTTER RAINER DR ,  SCHMIDT MARTIN DR ,  SUBKOWSKI THOMAS DR ,  ZECHEL JOHANN-CHRISTIAN DR

IPC: C07K14/575 ,  C12Q1/37 ,  C07K7/08 ,  G01N33/68

Abstract: The present invention relates to an assay method for identifying inhibitors of endothelin converting enzyme (ECE) and to substrates for use in this assay method.