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    2.
    发明专利
    未知

    公开(公告)号：CH615430A5

    公开(公告)日：1980-01-31

    申请号：CH211975

    申请日：1975-02-20

    Applicant: BASF AG

    Inventor： AMANN AUGUST DR ,  KOENIG HORST DR ,  THIEME PETER DR ,  GIERTZ HUBERT PROF DR ,  KRETZSCHMAR ROLF DR

    IPC: C07D285/12 ,  A61K31/41 ,  A61K31/433 ,  A61P25/08 ,  C07D285/125

    Abstract: 1494757 1,3,4-Thiadiazolium compounds BASF AG 20 Feb 1975 [21 Feb 1974] 7106/75 Heading C2C The invention comprises novel compounds (I) in which (a) R 2 , R 3 , R 4 , R 5 and R 6 are identical or different and are hydrogen, fluorine, chlorine, bromine, iodine, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms in the alkyl moiety, trifluoromethyl or NO 2 , at least one of the substituents R 2 to R 6 being different from hydrogen, and R 1 is alkyl or 2 to 6 carbon atoms which is optionally substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring, or (b) R 1 is methyl optionally substituted by phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring when at least two of R 2 to R 6 are different from hydrogen, or, when R 2 , R 3 , R 5 and R 6 have the above meanings, R 4 is hydrogen, fluorine, bromine, iodine, alkyl of 2 to 4 carbon atoms, alkoxy of 2 to 4 carbon atoms in the alkyl moiety, trifluoromethyl or NO 2 and at least one of R 2 , R 3 , R 4 , R 6 and R 6 is different from H, or (c) R 2 , R 3 , R 4 , R 5 and R 6 are each hydrogen when R 1 is alkyl of 3 to 6 carbon atoms which is optionally substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring or when R 1 is ethyl which is #-substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring, or (d) R 1 is methyl substituted by cycloalkyl of 3 to 6 carbon atoms in the ring when R 2 , R 3 , R 4 , R 5 and R 6 are each hydrogen or R 2 , R 3 , R 5 and R 6 are hydrogen and R 4 is chlorine. They are made by reacting compounds (II) (obtained by reacting compounds III with R 1 NHNH 2 ; the free acids corresponding to III are also prepared as are compounds IV) with carbon disulphide or thiophosgene. Pharmaceutical preparations having anticonvulsive action contain (I) as active ingredient. Administration is preferably orally.

    6.
    发明专利
    未知

    公开(公告)号：DE2208155A1

    公开(公告)日：1973-08-30

    申请号：DE2208155

    申请日：1972-02-22

    Applicant: BASF AG

    Inventor： GIESE BERND DR ,  JAEGER PETER DR ,  KOENIG HORST DR

    IPC: C25B3/25 ,  B01J23/00 ,  C07B61/00 ,  C07C67/00 ,  C07C209/00 ,  C07C209/30 ,  C07C209/40 ,  C07C209/52 ,  C07C211/38 ,  C07C87/40

    Abstract: 1396656 4 - Endotricyclo - (5,2,1,0 2,6-endo )- decylamine BADISCHE ANILIN- & SODAFABRIK AG 21 Feb 1973 [22 Feb 1972] 8476/73 Heading C2C A sterically uniform 4 - endotricyclo - (5,2,1, 0 2,6 -endo)-decylamine of Formula I is obtained by the reduction of a compound of Formula II in which X is H, OH or OCOR and R is C 1 -C 4 alkyl, the reduction being carried out either by heterogeneous catalytic hydrogenation in the presence of a member of the platinum group as catalyst or by electrochemical reduction. The preferred catalyst is platinum, which may be used in the form of its dioxide, but palladium, ruthenium or rhodium or mixtures of these metals may be used. When electrochemical reduction is used the preferred cathode material is liquid mercury and it may be used in the form of amalgams, e.g. with lead or silver, and the starting material is dissolved or suspended in a suitable electrolyte, e.g. an aqueous alcohol or aqueous dioxan or tetrahydrofuran.

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