公开(公告)号：DE2210799A1

公开(公告)日：1973-09-20

申请号：DE2210799

申请日：1972-03-07

Applicant: BASF AG

Inventor： THIELE UWE DR ,  KOENIG HORST DR ,  FOEHLISCH BALDUR DR ,  AMANN AUGUST DR ,  GIERTZ HUBERT PROF DR ,  SCHUSTER JOERG DR

IPC: C07D493/08 ,  C07D5/04

Abstract: Hexahydro-benzocyclononenes of formula (I): (where X is O and R' and R2 are different; R' being OH and R2 being 1-6C alkoxy; 7-9C aralkoxy; amino carrying a 1-6 C alkyl, 3-6C cycloalkyl or 7-9C aralkyl residue; or hydrazino opt. substd. by aryl, or R' and R2 are identical, and are amino groups carrying a 1-6C alkyl, 3-6C cycloalkyl or 7-9C aralkyl residue; amino groups derived from a 5- to 7-membered secondary cyclic amine; or hydrazino opt. subst. by aryl; or X is imino and R' and R2 are each OH). (I) have anticonvulsant, sedative, analgesic or anti-inflammatory activity. (I; X= O, R'=R2=pyrrolidino) also has hypertensive activity.

公开(公告)号：DE2300543A1

公开(公告)日：1974-07-11

申请号：DE2300543

申请日：1973-01-08

Applicant: BASF AG 6700 LUDWIGSHAFEN

Inventor： THIELE UWE DR ,  KOENIG HORST DR ,  SCHWANG HERIBERT DR ,  AMANN AUGUST DR ,  GIERTZ HUBERT PROF DR

IPC: C07D295/092 ,  C07C91/34 ,  A61K27/00 ,  C07D31/42 ,  C07D51/70 ,  C07D87/32

Abstract: Derivs. of formula (I) (where R1 is an alkyl; R2 is H or Br;and R3 and R4 are H, opt. substd. alkyl, aryl or cycloalkyl, or NR3R4 is a heterocyclic ring opt. contg. further hetero atoms which may be further substd. and one of R3 and R4 or NR3R4 opt. contains a further N-atom to which there may be attached a 3-(trimethylphenyxyl)-2-hydroxypropyl residue) and their acid addn. salts, are prepd. by reacting a cpd. of formula (II) (where Y is -CHCH2O or CHOH-CH2-Z in which Z is Cl or Br) with an amine HNR3R4.

公开(公告)号：DE2151587A1

公开(公告)日：1973-04-19

申请号：DE2151587

申请日：1971-10-16

Applicant: BASF AG

Inventor： KOENIG HORST DR ,  SCHWANG HERIBERT DR ,  THIELE UWE DR ,  AMANN AUGUST DR ,  GIERTZ HUBERT PROF DR ,  SCHUSTER JOERG DR

IPC: C07D295/08 ,  C07C217/34 ,  C07D295/092 ,  C07C93/26